Abstract:The data on plasma homocysteine and endogenous insulin in type 2 diabetes mellitus with nephropathy and relationship to body mass index (BMI) is particularly from the Indian subcontinent. A prospective study was carried out in 50 patients of type 2 diabetes mellitus with overt nephropathy (Group A). The results were compared with 25 diabetics without nephropathy (Group B), and 25 age and sex matched healthy controls (Group C). Microenzyme immunoassay and ELISA estimated the plasma homocysteine and insulin, res… Show more
“…These circumstances may have reduced the power to detect any differences associated with smoking, and the possibility of a type 2 error should be considered. Like in many previous studies, BMI and other markers for obesity were not significant determinants of Hcy [21,[43][44][45]. We cannot, however, conclusively rule out an association because levels of Hcy were highest in obese subjects in both men and women, and the possibility of insufficient power should be considered.…”
“…These circumstances may have reduced the power to detect any differences associated with smoking, and the possibility of a type 2 error should be considered. Like in many previous studies, BMI and other markers for obesity were not significant determinants of Hcy [21,[43][44][45]. We cannot, however, conclusively rule out an association because levels of Hcy were highest in obese subjects in both men and women, and the possibility of insufficient power should be considered.…”
“…Homocysteine is a sulphur‐containing non‐proteinogenic amino acid biosynthesized from methionine and abnormal elevation of circulating homocysteine concentrations has been implicated in the development of many clinical end‐points or pathological conditions, such as cardiovascular disease, stroke and microalbuminuria . Hyperhomocysteinaemia is an independent risk factor for glomeruloslerosis and renal insufficiency and the association of circulating homocysteine with DKD was widely evaluated in the medical literature, yet the results are not often reproducible . Actually, current evidence linking homocysteine to DKD is mainly based on observational data, in which the degree of possible confounding and reverse causation may cloud the true relationship .…”
Section: Discussionmentioning
confidence: 99%
“…17 Hyperhomocysteinaemia is an independent risk factor for glomeruloslerosis and renal insufficiency and the association of circulating homocysteine with DKD was widely evaluated in the medical literature, yet the results are not often reproducible. [7][8][9][18][19][20][21][22] Actually, current evidence linking homocysteine to DKD is mainly based on observational data, in which the degree of possible confounding and reverse causation may cloud the true relationship. 23,24 In this context, Mendelian randomization has proven to be a valuable method to overcome confounding and reverse causality 25,26 and this method enables estimation of causal relationship in observational studies using genetic alterations as instruments.…”
Diabetic kidney disease (DKD) is a devastating and frequent complication of diabetes mellitus. Here, we first adopted methylenetetrahytrofolate reductase (
MTHFR
) gene C677T polymorphism as an instrument to infer the possible causal relevance between circulating homocysteine and DKD risk in a Chinese population and next attempted to build a risk prediction model for DKD. This is a hospital‐based case‐control association study. Total 1107 study participants were diagnosed with type 2 diabetes mellitus, including 547 patients with newly diagnosed and histologically confirmed DKD.
MTHFR
gene C677T polymorphism was determined using the TaqMan method. Carriers of 677TT genotype (14.55 μmol/L) had significantly higher homocysteine concentrations than carriers of 677CT genotype (12.88 μmol/L) (
P
< 0.001). Carriers of 677TT genotype had a 1.57‐fold increased risk of DKD (odds ratio: 1.57, 95% CI: 1.21‐2.05,
P
= 0.001) relative to carriers of 677CT genotype after adjusting for confounders. Mendelian randomization analysis revealed that the odds ratio for DKD relative to diabetes mellitus per 5 μmol/L increment of circulating homocysteine concentrations was 3.86 (95% confidence interval: 1.21‐2.05,
P
< 0.001). In the Logistic regression analysis, hypertension, homocysteine and triglyceride were significantly associated with an increased risk of DKD and they constituted a risk prediction model with good test performance and discriminatory capacity. Taken together, our findings provide evidence that elevated circulating homocysteine concentrations were causally associated with an increased risk of DKD in Chinese diabetic patients.
“…A homocisteína pode aumentar a rigidez arterial e facilita absorção da LDL (YUN et al, 2011;THAMPI et al, 2008;KOUBAA et al, 2007). Segundo Coppola et al (2000) LIN et al, 2008;DE LUIS et al, 2005;SANDHU et al, 2004 et al, 2005).…”
Type 2 diabetes and cardiovascular disease (CVD) are diseases with high mortality and morbidity. Homocysteine and low density lipoprotein (LDL) have an influence on the formation of atheromatous plaques. However, the association of variables and rarely addressed in the literature, it is important to control the risks. The aim of this study was to evaluate the correlation between homocysteine and LDL in older women with type 2 diabetes. For primary research, quantitative cross-section were recruited 16 elderly women with type 2 diabetes. The group underwent collection of blood samples by venipuncture, which made the analysis of LDL and homocysteine. The results found that homocysteine is not correlated with LDL (P <0.781) and BMI is not related to homocysteine (P <0.426) and LDL (P <0.167). We can also observe that the systolic blood pressure is not related to homocysteine (P <0.148) and LDL (P <0.925) and diastolic blood pressure also not associated with homocysteine (P <0.125) and LDL (P <0.935). It is concluded that homocysteine not associated with LDL levels, body mass index and blood pressure.
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