Plasma histamine concentration and histamine detection in peripheral blood eosinophils in cats

Kadoya, Michiyo; Momoi, Yasuyuki; Iwasaki, Tadaaki

doi:10.1016/j.jfms.2006.02.006

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Levels of histamine metabolites have also been reported in a few studies in dogs, including in a few experimental anaphylaxis projects [ 33 ], but not in a context of clinical anaphylaxis [ 34 ]. There is even less literature about serum histamine concentrations in cats [ 35 ]. It is possible that research has been limited in veterinary patients because clinicians have not felt the need for a laboratory test to help them diagnose an anaphylactic reaction or detect it earlier, before clinical signs become more obvious.…”

Section: Humoral In Vitro Testsmentioning

confidence: 99%

In Vitro Research Tools in the Field of Human Immediate Drug Hypersensitivity and Their Present Use in Small Animal Veterinary Medicine

Lavergne

2016

Veterinary Sciences

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Drug hypersensitivity reactions (DHR) are immune-mediated idiosyncratic adverse drug events. Type I DHR are often referred to as “immediate” and involve B lymphocyte-secreted IgE that bind to the membrane of basophils and mast cells, inducing their degranulation. This review presents various in vitro tests that were developed in the field of human type I HS and implemented as clinical diagnostic tools in human cases of immediate DHR. The respective strengths and weaknesses of each test will be discussed in parallel of validation data such as specificity and sensitivity whenever available. Some of them have also been used as diagnostic tools in veterinary medicine, but not in cases of immediate DHR. Most of these diagnostic tools can be categorized into humoral and cellular tests. The former tests measure serum concentrations of factors, such as histamine, tryptase, and drug-specific IgE. The latter assays quantify markers of drug-induced basophil activation or drug-specific lymphocyte proliferation. Pharmacogenetic markers have also been investigated in immediate DHR, but not as extensively as in non-immediate ones. Throughout, practical aspects and limitations of the tests, as well as sensitivity and specificity parameters, will be presented. In addition, the experience of veterinary medicine with these diagnostic tools will be summarized. However, to date, none of them has ever been reported in a veterinary case of type I DHR.

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Section: Humoral In Vitro Testsmentioning

confidence: 99%

In Vitro Research Tools in the Field of Human Immediate Drug Hypersensitivity and Their Present Use in Small Animal Veterinary Medicine

Lavergne

2016

Veterinary Sciences

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“…34,35 Similarly, normal values in dogs and cats have been reported to be o1 ng/mL. 31,32 Histamine Physiology and Pathophysiology…”

Section: Histamine Measurementmentioning

confidence: 97%

“…28 An enzyme immunoassay has also been developed that has specificity and sensitivity similar to the radioimmunoassay 29 and has been validated for measurement of plasma histamine in animals. [29][30][31][32] Concentrations above 1 ng/mL are considered elevated in human beings 33 and concentrations 42 ng/mL are often correlated with cardiovascular changes. 34,35 Similarly, normal values in dogs and cats have been reported to be o1 ng/mL.…”

Section: Histamine Measurementmentioning

confidence: 99%

Histamine: metabolism, physiology, and pathophysiology with applications in veterinary medicine

Peters

Kovacic

2009

J Vet Emergen Crit Care

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Histamine plays a key role in the morbidity and mortality associated with allergy, asthma, gastric ulcers, anaphylaxis, sepsis, hemorrhagic shock, anesthesia, surgery, cardiovascular disease, cancer, CNS disorders, and immune-mediated disease. Histamine antagonism has been in common use to block its adverse effects. With recent advances in the understanding of histamine receptor physiology, pharmaceutical agents targeting these receptors have increased the therapeutic options.

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“…Cats with allergic dermatitis often show characteristic skin lesions including miliary dermatitis, eosinophilic granulomata, neurodermatitis, and selfinduced symmetric alopecia [7]. These lesions are characterized histopathologically by intensive accumulation of eosinophils [12], and marked eosinophilia is often observed in affected cats [6]. Eosinophils are thus thought to play a key role in the pathogenesis of feline allergic dermatitis.…”

mentioning

confidence: 99%

Measurement of Feline Serum Interleukin-5 Level

Nakazato

Momoi

Kadoya

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. A bioassay was developed to measure feline interleukin-5 (IL-5). Human IL-5 receptor α chain transfected murine Ba/F3 cells (Ba/F3-IL-5R) showed feline IL-5-dependent proliferation in a dose-dependent manner. IL-5 levels in serum samples from 54 cats with suspected allergic dermatitis and from 11 control cats could be successfully measured using Ba/F3-IL-5R cells. The number of eosinophils in peripheral blood was not correlated with serum IL-5 level. KEY WORDS: eosinophil, feline, interleukin-5.J. Vet. Med. Sci. 69(8): 843-846, 2007 Feline allergic dermatitis is a common recurrent, pruritic skin disorder with an onset in young animals [14]. The clinicopathological features of allergic dermatitis in cats resemble those in dogs and humans; elevation of antigenspecific IgE [13], positive reaction to sensitized antigens on intradermal skin testing [7], and increased numbers of peripheral blood eosinophils. Cats with allergic dermatitis often show characteristic skin lesions including miliary dermatitis, eosinophilic granulomata, neurodermatitis, and selfinduced symmetric alopecia [7]. These lesions are characterized histopathologically by intensive accumulation of eosinophils [12], and marked eosinophilia is often observed in affected cats [6]. Eosinophils are thus thought to play a key role in the pathogenesis of feline allergic dermatitis.Interleukin-5 (IL-5) is a glycoprotein with a molecular weight of 40-50 kDa [20] produced mainly by activated T lymphocytes and mast cells in mice and humans. The primary target of IL-5 is B lineage cells, to induce their growth and differentiation [16]. In addition, IL-5 is regarded as a major soluble factor regulating the differentiation, proliferation, and activation of eosinophils. IL-5 facilitates both the proliferation of eosinophilic precursors and their differentiation into mature eosinophils in bone marrow [2,23]. It also increases the migration of eosinophils to local lesions [15,21], maintains the survival of mature eosinophils by inhibiting apoptosis [21,22], and directly induces eosinophil degranulation and superoxide production [4,5] in humans. It is reported that serum IL-5 levels are significantly higher in human patients with asthma, and a significant positive correlation was found between the serum concentration of IL-5 and that of eosinophil cationic protein [9]. Administration of an anti-IL-5 antibody blocked eosinophilia more effectively than anti-IL-3 or anti-GM-CSF antibody in a mouse model of allergy [17]. These findings suggest that IL-5 is the most important factor regulating the number and action of eosinophils. Inhibition of IL-5 production or activity may be a target for the control of eosinophil-mediated allergic conditions.In humans, specific monoclonal antibodies to IL-5 have been developed. Serum IL-5 concentration can be measured by enzyme-linked immunosorbent assay (ELISA) or radioimmunoassay using anti-IL-5 monoclonal antibodies. To the authors' knowledge, however, serum IL-5 levels have not been measured in cats, because of the la...

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Plasma histamine concentration and histamine detection in peripheral blood eosinophils in cats

Cited by 6 publications

References 21 publications

In Vitro Research Tools in the Field of Human Immediate Drug Hypersensitivity and Their Present Use in Small Animal Veterinary Medicine

In Vitro Research Tools in the Field of Human Immediate Drug Hypersensitivity and Their Present Use in Small Animal Veterinary Medicine

Histamine: metabolism, physiology, and pathophysiology with applications in veterinary medicine

Measurement of Feline Serum Interleukin-5 Level

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