Plasma glucose, lactate, sodium, and potassium levels in children hospitalized with acute alcohol intoxication

Tõnisson, Mailis; Tillmann, Vallo; Kuudeberg, Anne; Väli, Marika

doi:10.1016/j.alcohol.2010.07.001

Cited by 14 publications

(13 citation statements)

References 22 publications

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“…Stimulation of β2-adrenergic receptors in skeletal muscle due to respiratory alkalosis contributes to the development of hypokalemia. It is recommended to measure plasma potassium, sodium, glucose, and lactate levels among patients with alcohol intoxication [ 117 ]. Potassium and platelet levels are crucial in predicting the severity of alcohol withdrawal [ 118 , 119 ].…”

Section: Plasma Potassium Deficitmentioning

confidence: 99%

Magnesium, Calcium, Potassium, Sodium, Phosphorus, Selenium, Zinc, and Chromium Levels in Alcohol Use Disorder: A Review

Baj

Flieger

Teresiński

et al. 2020

JCM

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Macronutrients and trace elements are important components of living tissues that have different metabolic properties and functions. Trace elements participate in the regulation of immunity through humoral and cellular mechanisms, nerve conduction, muscle spasms, membrane potential regulation as well as mitochondrial activity and enzymatic reactions. Excessive alcohol consumption disrupts the concentrations of crucial trace elements, also increasing the risk of enhanced oxidative stress and alcohol-related liver diseases. In this review, we present the status of selected macroelements and trace elements in the serum and plasma of people chronically consuming alcohol. Such knowledge helps to understand the mechanisms of chronic alcohol-use disorder and to progress and prevent withdrawal effects, also improving treatment strategies.

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Section: Plasma Potassium Deficitmentioning

confidence: 99%

Magnesium, Calcium, Potassium, Sodium, Phosphorus, Selenium, Zinc, and Chromium Levels in Alcohol Use Disorder: A Review

Baj

Flieger

Teresiński

et al. 2020

JCM

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“…Other investigators have reported relationships between alcohol [16, 14, 12, 13] and cocaine intoxication [16, 17] and elevated initial lactate levels. Although these findings were not replicated in the current study, we did find a very strong relationship between THC use and elevated lactate levels with 15/16 (OR 15 95%CI 1.56– 693.14) patients who screened positive for THC having an elevated initial lactate level.…”

Section: Discussionmentioning

confidence: 99%

Initial venous lactate levels in patients with isolated penetrating extremity trauma: a retrospective cohort study

Folkert

Sims

Pascual

et al. 2014

Eur J Trauma Emerg Surg

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INTRODUCTION Elevated initial lactate levels have been shown to be associated with severe injury in trauma patients, but some patients who do not appear to be in shock also present with elevated lactate levels. We hypothesized that in hemodynamically stable patients with isolated penetrating extremity trauma, initial lactate level does not predict clinically significant bleeding. METHODS A 5-year institutional database review was performed. Hemodynamically stable patients (HR<101, SBP>90) with isolated penetrating extremity trauma with an initial lactate sent were included. The exposure of interest was captured as a dichotomous variable by initial lactate level Normal (N≤2.2 mEq/l), Elevated (E >2.2. mEq/l). The primary outcome measurement was clinically significant bleeding, defined by need for intervention (operation, angioembolization, or transfusion) or laboratory evidence of bleeding (presenting Hg<7g/dL, or Hg decrease by >2g/dL/24hours). Chi-squared and Mann-Whitney tests were used to compare variables. RESULTS A total of 132 patients were identified. There were no differences in demographics or mechanism of injury between the N (n=43, 7%) and E (n=89, 14%) groups. Median lactate levels were 1.6 (IQR 1.2–1.9) mEq/dL vs. 3.8 (IQR 2.8–5.2) in the N and E groups, p<0.001. Lactate was elevated in 89 (67%) patients but was not associated with clinically significant bleeding (37% elevated vs. 39% not elevated p=0.82). CONCLUSIONS In hemodynamically stable patients with isolated penetrating trauma to the extremity, elevated initial venous lactate levels (>2.2mEq/l) are not associated with bleeding or need for interventions. Clinical judgment remains the gold standard for evaluation and management of these patients.

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“…; Tonisson et al. ) to name a few. Additionally, these traditional techniques exclude small organic ions which can aid in diagnosis and understanding disease progression such as in cancer (Hirschhaeuser et al.…”

Section: Introductionmentioning

confidence: 99%

“…The necessity in measurement of cations and anions spans a vast array of physiological conditions, ranging from: hypertension (Foss et al 2013;Gomes et al 2017;Kopp et al 2012;Lohmeier et al 2005;Osborn et al 2012;Stocker et al 2015), water and electrolyte homeostasis (Mack et al 1994;Nose et al 1988;Schreihofer et al 1999), stroke (Chung et al 2015;Rappaport et al 1987), and alcohol intoxication (Avery et al 1983;Liamis et al 2000;Tonisson et al 2010) to name a few. Additionally, these traditional techniques exclude small organic ions which can aid in diagnosis and understanding disease progression such as in cancer (Hirschhaeuser et al 2011;Kamphorst et al 2014;Semenza 2008).…”

Section: Introductionmentioning

confidence: 99%

Measurement of cations, anions, and acetate in serum, urine, cerebrospinal fluid, and tissue by ion chromatography

et al. 2018

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Accurate quantification of cations and anions remains a major diagnostic tool in understanding diseased states. The current technologies used for these analyses are either unable to quantify all ions due to sample size/volume, instrument setup/method, or are only able to measure ion concentrations from one physiological sample (liquid or solid). Herein, we adapted a common analytical chemistry technique, ion chromatography and applied it to measure the concentration of cations; sodium, potassium, calcium, and magnesium (Na+, K+, Ca2+, and Mg2+) and anions; chloride, and acetate (Cl−, − OAc) from physiological samples. Specifically, cations and anions were measured in liquid samples: serum, urine, and cerebrospinal fluid, as well as tissue samples: liver, cortex, hypothalamus, and amygdala. Serum concentrations of Na+, K+, Ca2+, Mg2+, Cl−, and − OAc (mmol/L): 138.8 ± 4.56, 4.05 ± 0.21, 4.07 ± 0.26, 0.98 ± 0.05, 97.7 ± 3.42, and 0.23 ± 0.04, respectively. Cerebrospinal fluid concentrations of Na+, K+, Ca2+, Mg2+, Cl−, and − OAc (mmol/L): 145.1 ± 2.81, 2.41 ± 0.26, 2.18 ± 0.38, 1.04 ± 0.11, 120.2 ± 3.75, 0.21 ± 0.05, respectively. Tissue Na+, K+, Ca2+, Mg2+, Cl−, and − OAc were also measured. Validation of the ion chromatography method was established by comparing chloride concentration between ion chromatography with a known method using an ion selective chloride electrode. These results indicate that ion chromatography is a suitable method for the measurement of cations and anions, including acetate from various physiological samples.

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Plasma glucose, lactate, sodium, and potassium levels in children hospitalized with acute alcohol intoxication

Cited by 14 publications

References 22 publications

Magnesium, Calcium, Potassium, Sodium, Phosphorus, Selenium, Zinc, and Chromium Levels in Alcohol Use Disorder: A Review

Magnesium, Calcium, Potassium, Sodium, Phosphorus, Selenium, Zinc, and Chromium Levels in Alcohol Use Disorder: A Review

Initial venous lactate levels in patients with isolated penetrating extremity trauma: a retrospective cohort study

Measurement of cations, anions, and acetate in serum, urine, cerebrospinal fluid, and tissue by ion chromatography

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