Plasma Glucose, Insulin, Pancreatic, and Enteroglucagon Levels in Normal and Depancreatized Dogs

Insulin releasing activity of gastrointestinal glucagon-like immunoreactive materials in perfused rat pancreas.

“…Furthermore, recent reports by Matsuyama and Foa (1974), Vranic et al(1974) and Sasaki et al(1975) suggest the presence of glucagon immunoreactivity, which reacted with antibody specific for pancreatic glucagon, in the gastrointestinal tract, especially abundant in the gastric fundus (Matsuyama et al, 1977). The biological activities of this material were reported to be close to those of pancreatic glucagon, as far as glycogenolytic and adenylate cyclase stimulating activities were concerned (Sasaki et al, 1975).…”

Response of extrapancreatic glucagon to gastrointestinal hormones in pancreatectomized dogs.

“…Intravenous administration of CCK-octa in a dose of 20 U/kg did not affect the plasma level of glucagon during saline infusion but exerted a significant rise of extrapancreatic glucagon during arginine infusion. It is concluded from the present experiment that the administration of tetragastrin, caerulein or CCK-octa enhances the release of extrapancreatic glucagon stimulated by arginine infusion while secretin infusion does not affect the secretion of extrapancreatic glucagon.tetragastrin ; secretin ; caerulein ; CCK-octapeptide ; arginine Since the establishment of the presence of extrapancreatic glucagon (Matsuyama and Foa 1974;Vranic et al 1974), the regulation of extrapancreatic glucagon has been reported by many authors (Lefebvre and Luyckx 1981;Ohneda 1981). Among various factors, gastrointestinal factors have been considered to play an important role in the secretion of extrapancreatic glucagon.…”

“…tetragastrin ; secretin ; caerulein ; CCK-octapeptide ; arginine Since the establishment of the presence of extrapancreatic glucagon (Matsuyama and Foa 1974;Vranic et al 1974), the regulation of extrapancreatic glucagon has been reported by many authors (Lefebvre and Luyckx 1981;Ohneda 1981). Among various factors, gastrointestinal factors have been considered to play an important role in the secretion of extrapancreatic glucagon.…”

Secretion of glucagon in liver cell carcinoma.

“…Recently glucagon in the gut has been designated as extrapancreatic glucagon (Vranic et al 1974 ;Matsuyama and Foa 1974), which cannot be distinguished by immunoassay from pancreatic glucagon. Therefore, an increased response of plasma glucagon observed in liver cell carcinoma might derive from extrapancreatic glucagon.…”