Insulin releasing activity of gastrointestinal glucagon-like immunoreactive materials in perfused rat pancreas.

Tanaka, Ryoichi; Matsuyama, Tatsuo; Shima, Kenji; Sawazaki, N; Tarui, Seiichiro; Kumahara, Yuichi

doi:10.1507/endocrj1954.24.575

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…Glucagon-like immunoreactivity in the serum is a heterogenous group of peptides, some of which fall in the molecular weight range of our Frs (24). In our serum fractions the level of IRG was definitively lower than the minimum required for the stimulation of insulin release reported by other investigators (25).…”

Section: Detection Limitcontrasting

confidence: 41%

Insulinotropic Activity in the Serum of Obese and Nonobese Infants and Children

et al. 1986

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Section: Detection Limitcontrasting

confidence: 41%

Insulinotropic Activity in the Serum of Obese and Nonobese Infants and Children

et al. 1986

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“…Crude duck gut GLI with a molecular weight of 6000 to 13 000 was found to inhibit the glucagon-induced lipolysis of duck adipocytes (Krug and Mialhe, 1977). Partially purified porcine gut GLI with a molecular weight of approximately 4000 has been found to inhibit the binding of 1251-glucagon to liver plasma membranes, to stimulate liver plasma membrane adenyl cyclase (Bataille et al, 1974;Moody et al, 1975), and also to stimulate insulin release (Tanaka et al, 1977). With the exception of the displacement of 1251_ glucagon from liver plasma membranes, these effects could well have been caused by a contaminating peptide such as VIP.…”

Section: Biological Effectsmentioning

confidence: 99%

Gut glucagon-like immunoreactants (GLIs) and other enteric glucagon-like peptides.

Moody¹

1978

Journal of Clinical Pathology

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The term glucagon was coined by Kimball and an immunoreactant in common with glucagon (gut Murlin (1923) to describe a hyperglycaemic sub-GLIs). The extensive similarities between the stance which they had partially purified from an sequences of glucagon, VIP, secretin, and GIP have extract of bovine pancreas. In 1953, Staub et al. been discussed elsewhere in these proceedings. The crystallised a pancreatic hyperglycaemic glyco-four peptides have very similar spectra of biological genolytic factor (HGF), for which they accepted the effects: secretin, glucagon, and VIP stimulate name glucagon in 1955 (Staub et al., 1955 (Sundby, 1976). the peptides to separate receptors on the cell surface. Avian glucagons differ from porcine glucagon; for The physiology of secretin, VIP, and GIP is described example turkey glucagon differs by having a serine elsewhere in these proceedings so the remainder of residue at position 28 instead of asparagine, and this section is restricted to the gut glucagon-like duck glucagon by also having a threonine at position immunoreactants (gut GLIs).

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Glucagon, Glicentin, and Related Peptides

Moody¹,

Thim²

1983

Glucagon I

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Insulin releasing activity of gastrointestinal glucagon-like immunoreactive materials in perfused rat pancreas.

Cited by 6 publications

References 12 publications

Insulinotropic Activity in the Serum of Obese and Nonobese Infants and Children

Insulinotropic Activity in the Serum of Obese and Nonobese Infants and Children

Gut glucagon-like immunoreactants (GLIs) and other enteric glucagon-like peptides.

Glucagon, Glicentin, and Related Peptides

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