Insulinotropic Activity in the Serum of Obese and Nonobese Infants and Children

Lautala, Pentti; Åkerblom, Hans K.; Kouvalainen, K; Martin, Joseph V.

doi:10.1203/00006450-198608000-00004

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…There is some debate as to whether hyperinsulinism and insulin resistance precede the development of obesity or whether the reverse is true. Lautala et al [26] have shown that the plasma of obese children has increased islet stimulating activity compared to the plasma of nor mal weight control children, thus suggesting a defect in the regulation of insulin secretion in these individuals. Further supporting this hypothesis is a recent study by Alemzadeh et al [27] which demonstrated decreased weight gain and increased insulin sensitivity in obese Zucker rats when diazoxide treatment was used to sup press insulin secretion.…”

Section: Discussionmentioning

confidence: 99%

Altered Insulin Resistance Is Associated with Increased Dietary Weight Loss in Obese Children

Hoffman¹,

Stumbo²,

Janz³

et al. 1995

Horm Res

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To determine the relationship between insulin resistance and weight loss in early obesity, we used the euglycemic, hyperinsulinemic clamp to study the effect of a 14-day weight reduction diet in 10 prepubertal and early pubertal obese children (age, 10.1 ± 1.6 years) on insulin sensitivity. Body weight decreased from 73.7 ± 6.0 kg to 69.1 ± 5.8 kg (p < 0.01). Insulin sensitivity before weight reduction negatively correlated with the amount of weight loss during diet (r = -0.8, p < 0.005). Weight loss also positively correlated with height standard deviation score (r = 0.9, p < 0.005). Mean insulin sensitivity increased from 0.068 ± 0.01 (nmol kg^-1 min^-1 H) (pmol 1^-1) to 0.096 ± 0.030 (nmol kg^-1 min^-1)/(pmol 1^-1) (p < 0.05, one-tailed test). These results indicate that weight reduction decreases insulin resistance in childhood obesity. The inverse relationship between insulin sensitivity and weight loss during calorie restriction in these subjects suggests that insulin resistance may enhance weight loss during calorie restriction.

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Section: Discussionmentioning

confidence: 99%