Plasma fructosamine in non‐diabetic pregnancy

Staley, Michael J.; Murray-Arthur, F.

doi:10.1111/j.1471-0528.1988.tb06867.x

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…As reported by many others, fructosamine decreases with decrease of serum albumin concentration in advanced pregnancy. 3 Our results showed that total protein was decreased slightly, but significantly, in middle and late pregnancy, suggesting an apparent decrease in the fructosamine level. The fasting plasma glucose and glycated albumin values in the glycosuria group were slightly, but not significantly, higher than those in the normal group.…”

Section: Discussionmentioning

confidence: 60%

Serum Glycated Albumin Concentrations during Pregnancy

Abe

Miyamoto

Tahara³

et al. 1993

Ann Clin Biochem

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Additional key phrases: diabetes mellitus; haemoglobin Ale; glycated protein; fructosamineMany studies have been shown that fetal malformation and abnormal growth are significantly increased in pregnancies with poorly-controlled diabetes mellitus and that intensive glycaemic control is required in diabetic pregnancy. 1 Various indices including haemoglobin Ale, glycated protein and fructosamine are reported to be useful for assessing glycaemic control during pregnancy.t-' Glycated protein and fructosamine reflect glycaemic control levels over a shorter period, and so presumably more rapidly, than HbA1c" Measurement of glycated albumin seems more suitable than that of glycated protein because metabolism of serum albumin is better understood than that of other serum proteins. There are many reports of the usefulness of glycated albumin for assessing glycaemic control levels in non-pregnant diabetic patients. However, as there seem to be no reports on its value during pregnancy, we examined the changes of glycated albumin during pregnancy in comparison with those of other measurements. SUBJECTS AND METHODThe subjects studied were 249 pregnant women with normal glucose tolerance before pregnancy. Their fasting plasma glucose, serum total protein (T'P), glycated albumin, fructosarnine, HbA le and urinary glucose concentrations were examined several times between week 10 and 37 of pregnancy. The women were classified into three groups: a normal group, 225 women showed neither glycoCorrespondence: Dr Kenji Shima.198 suria nor hyperglycaemia (fasting glucosẽ 6'1 mmollL) throughout pregnancy; glycosuria group, 13 women who showed glycosuria at least once but not hyperglycaemia; and a hyperglycaernia group, 11 women who showed a fasting glucose concentration of > 6· 1 mmollL at least once. Glycated albumin was measured by column affinity chromatography by the HPLC method described previously. 4 Fructosamine was measured by the nitroblue tetrazolium method with an assay kit from Hoffmann-La Roche Co. (Basle, Switzerland). HbA\c was measured by an HPLC method, and plasma glucose by the international standard method with glucose dehydrogenase. Serum total protein was measured by the biuret method. The coefficients of variation of these assays for glycated albumin, fructosamine, HbA le, plasma glucose and total protein were 3'6,1-7,2-6,2'3 and 0-6l1Jo, respectively. The mean glycated albumin in 153 non-pregnant women aged 18 to 30 (mean 20' 3, SD 2· 5 years) with normal glucose tolerance was 15'6, SD 0·6%.For analysis, data were grouped into three gestational periods (weeks 10-19, 20-29, and 30-37 of gestation) named early, middle and late pregnancy, respectively. Data are given as means (SD). Statistical significance was analysed by ttest for paired and unpaired data or by analysis of variance. RESULTSThe results are summarized in Table 1. In normal pregnant women, fasting plasma glucose and glycated albumin did not change significantly as pregnancy progressed, total protein and fructosamine concentrations were significant...

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Section: Discussionmentioning

confidence: 60%

Serum Glycated Albumin Concentrations during Pregnancy

Abe

Miyamoto

Tahara³

et al. 1993

Ann Clin Biochem

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Fructosamine as a screening‐test for gestational diabetes mellitus: a reappraisal

Nasrat

Ajabnoor

Ardawi

1991

Intl J Gynecology & Obste

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Fructosamine, glycosylated hemoglobin (HbA1c) and serum total proteins were measured in normal nondiabetic pregnant women (n = 170) at three stages of pregnancy (14-18, 24-28, and 32-40 weeks of gestation). No significant correlation was found between fructosamine and either HbA1c or total plasma proteins. Only early in pregnancy (less than 20 weeks of gestation) was a correlation found between fructosamine and fasting blood glucose (r = 0.40, P less than 0.05). There was also no correlation between either tests (i.e. fructosamine and HbA1c) and fetal birthweight. The value of fructosamine measurement in the detection of diabetes in pregnancy was further tested in a group of high-risk patients (n = 98) for developing carbohydrate intolerance. It is concluded that fructosamine has limited value as a screening test for gestational diabetes mellitus, particularly for the mild form of the glucose intolerance.

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Value of fructosamine measurement in pregnant women with abnormal glucose tolerance

Yang²

2006

Chinese Medical Journal

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Plasma fructosamine in non‐diabetic pregnancy

Cited by 3 publications

References 18 publications

Serum Glycated Albumin Concentrations during Pregnancy

Serum Glycated Albumin Concentrations during Pregnancy

Fructosamine as a screening‐test for gestational diabetes mellitus: a reappraisal

Value of fructosamine measurement in pregnant women with abnormal glucose tolerance

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