Plasma Flt3-ligand as a Biomarker for Radiation Exposure

Sproull, Mary; Avondoglio, Dane; Meushaw, Tamalee; Shankavaram, Uma; Camphausen, Kevin

doi:10.1016/j.ijrobp.2010.07.1479

Cited by 1 publication

(1 citation statement)

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“…Flt3lg showed elevated levels at all time points in the time windows of 1 to 7 days after exposure to radiation doses ≥ 1 Gy, and their maximum changes increased with increasing radiation doses. Previous studies also reported the increase of Flt3lg level after exposure to different radiation doses, although the maximum and temporal concentration changes varied among different mice strains3143. Saa1 showed elevated levels only during the first two days after exposure exhibiting maximum changes at day 1.…”

Section: Discussionmentioning

confidence: 76%

Nanosensor dosimetry of mouse blood proteins after exposure to ionizing radiation

Kim

Marchetti

Chen

et al. 2013

Sci Rep

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Giant magnetoresistive (GMR) nanosensors provide a novel approach for measuring protein concentrations in blood for medical diagnosis. Using an in vivo mouse radiation model, we developed protocols for measuring Flt3 ligand (Flt3lg) and serum amyloid A1 (Saa1) in small amounts of blood collected during the first week after X-ray exposures of sham, 0.1, 1, 2, 3, or 6 Gy. Flt3lg concentrations showed excellent dose discrimination at ≥ 1 Gy in the time window of 1 to 7 days after exposure except 1 Gy at day 7. Saa1 dose response was limited to the first two days after exposure. A multiplex assay with both proteins showed improved dose classification accuracy. Our magneto-nanosensor assay demonstrates the dose and time responses, low-dose sensitivity, small volume requirements, and rapid speed that have important advantages in radiation triage biodosimetry.

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Section: Discussionmentioning

confidence: 76%