Plasma fetuin‐<scp>A</scp> is associated with endothelial dysfunction and subclinical atherosclerosis in subjects with nonalcoholic fatty liver disease

Doğru, Teoman; Genç, Halil; Tapan, Serkan; Aslan, Fatih; Erçin, Cemal Nuri; Örs, Fatih; Kara, Muammer; Sertoğlu, Erdim; Karslioğlu, Yıldırım; Bağcı, Sait; Kurt, İsmail; Sönmez, Alper

doi:10.1111/j.1365-2265.2012.04460.x

Cited by 82 publications

(69 citation statements)

References 31 publications

(57 reference statements)

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“…Adiponectin is influenced by and affects the action of many pathophysiological mechanisms, including nonspecific systemic inflammation, increase/decrease in body weight, body constitution and chronic diseases [77]. Lower concentration of adiponectin in serum is noted in patients with NAFLD [90,93]. There is evidence that its concentration is negatively correlated with the content of fat in the www.ah.viamedica.pl liver.…”

Section: Adipose Tissue and Its Activitymentioning

confidence: 99%

“…These reactions can reduce the elastic properties of the arteries and cause the development of endothelial dysfunction (ED). Different studies of the concentrations of inflammation markers such as high sensitive CRP, TNF-a, IL-6, leukocytes count in patients with NAFLD were conducted [84,93,99]. It was shown that nonspecific chronic systemic inflammation had led to the development of ED in patients with NAFLD [93,96,99].…”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

“…Different studies of the concentrations of inflammation markers such as high sensitive CRP, TNF-a, IL-6, leukocytes count in patients with NAFLD were conducted [84,93,99]. It was shown that nonspecific chronic systemic inflammation had led to the development of ED in patients with NAFLD [93,96,99]. Zitona link of immunity is considered as one of the pathogenetic factors in the formation of ED, the processes of cytolysis in hepatocytes and the subsequent development and progression of NAFLD.…”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

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Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Kuzmіnova

Gribenyuk

Osovska

et al. 2016

Arterial Hypertension

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The combination of hypertension, obesity and non-alcoholic fatty liver disease occurs in medical practice very often. A number of studies have shown that non-alcoholic fatty liver disease increases the risk of cardiovascular disease independently of other predictors and manifestations of the metabolic syndrome. Current issues of research and identification of common pathogenic relationships of obesity, hypertension, and liver steatosis are investigated in the article. According to the analysed literature, it is indicated that insulin resistance and compensatory hyperinsulinaemia are considered as one of the key factors in the development of this comorbidity. The processes of chronic inflammation are increasing with the growth of adipose tissue volume. Some researchers believe that non-specific systemic inflammation combines arterial hypertension, increased body weight (especially abdominal obesity), steatosis, dyslipidaemia, atherogenesis and arteriosclerosis into a single syndrome. The role of non-alcoholic fatty liver disease in the growth of the thickness of the intima-media complex was studied. It is known that adipose tissue functions as an endocrine organ, expresses genes encoding bioactive substances, and secretes certain cytokines. A strong link between dysfunction of adipose tissue in patients with non-alcoholic fatty liver disease and in such conditions as metabolic syndrome and cardiovascular disease was demonstrated. The dysfunction of the endothelium is also advisable to consider as the connecting link between liver disease, obesity and hypertension. Despite some understanding of common pathogenic mechanisms for the development of non-alcoholic fatty liver disease and hypertension, this comorbid pathology remains the subject of much debate and a variety of studies. key words: arterial hypertension, obesity, non-alcoholic fatty liver disease, insulin resistance, dyslipidaemia, non-specific systemic inflammation, endothelial dysfunction, atherogenesis.

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Section: Adipose Tissue and Its Activitymentioning

confidence: 99%

Section: Endothelial Dysfunctionmentioning

confidence: 99%

Section: Endothelial Dysfunctionmentioning

confidence: 99%

See 1 more Smart Citation

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Kuzmіnova

Gribenyuk

Osovska

et al. 2016

Arterial Hypertension

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“…Higher levels of fetuin-A are associated with obesity, insulin resistance, NAFLD, myocardial infarction and ischemic stroke in general population (9)(10)(11)(12). In addition, circulating fetuin-A is independently related with endothelial dysfunction and subclinical atherosclerosis in NAFLD (8).…”

Section: Introductionmentioning

confidence: 98%

“…It is a glycoprotein completely produced in the liver and is secreted into circulation. Fetuin-A induces insulin resistance in liver and skeletal muscle by inhibition of insulin receptor in these target tissues (8). Higher levels of fetuin-A are associated with obesity, insulin resistance, NAFLD, myocardial infarction and ischemic stroke in general population (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Effects of Turmeric on Homocysteine and Fetuin-A in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Double-Blind Placebo-Controlled Study

Ghaffari

Rafraf

Navekar

et al. 2017

Iran Red Crescent Med J

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Association of nonalcoholic fatty liver disease and carotid media‐intima thickness: A systematic review and a meta‐analysis

Khoshbaten,

Maleki,

Hadad

et al. 2023

Health Science Reports

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IntroductionThe relationship between cardiovascular disorders and nonalcoholic fatty liver disease (NAFLD) has been extensively studied. To better pool this data and make a more definite conclusion, we performed a meta‐analysis to evaluate the association between NAFLD and the thickness of media and intima of carotid artery (CIMT) and cardiovascular disorders.MethodsWe searched PubMed, Ovid, Scopus, ProQuest, Web of Science, and the Cochrane Library, and analyzed the pooled data using R studio and the “metafor” package.ResultsThe final analysis included a total of 59 studies with 16,179 cases and 26,120 control individuals. NAFLD was shown to be associated with an increase of 0.1231 mm (20.6%) in carotid artery intima‐media thickness (CIMT) (p = 0.002, 95% confidence interval [CI]: 0.0462–0.2000) in individuals with NAFLD. The prevalence of atherosclerotic plaques in the carotid arteries and the occurrence of NAFLD are significantly correlated, according to a meta‐analysis based on 17 distinct studies (p = 0.001, 1.28–1.43, 95% CI, odds ratio = 1.356).ConclusionPatients with increased CIMT are considerably more likely to have NAFLD. Large prospective investigations are required to corroborate these findings and their prognostic significance, along with the effectiveness of the available interventions.

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Plasma fetuin‐A is associated with endothelial dysfunction and subclinical atherosclerosis in subjects with nonalcoholic fatty liver disease

Abstract: This study demonstrated for the first time that circulating fetuin-A in NAFLD is independently associated with endothelial dysfunction and subclinical atherosclerosis.

Cited by 82 publications

References 31 publications

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Arterial hypertension, obesity and non-alcoholic fatty liver disease: is there any connection?

Effects of Turmeric on Homocysteine and Fetuin-A in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Double-Blind Placebo-Controlled Study

Association of nonalcoholic fatty liver disease and carotid media‐intima thickness: A systematic review and a meta‐analysis

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