Plasma Epinephrine and Norepinephrine Levels During Insulin-Induced Hypoglycemia in Man*†

Goldfien, Alan; Moore, Richard O.; Zileli, S; Havens, Leston L.; Boling, Lenore; Thorn, George W.

doi:10.1210/jcem-21-3-296

Cited by 92 publications

(40 citation statements)

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“…However, the resulting hypoglycaemia promotes the secretion of adrenaline and noradrenaline (Goldfien, 1961) and this increase in circulating catecholamines raises the plasma NEFA concentration (Mueller & Horwitz, 1962). Pilkington, Lowe, Robinson & Titterington (1962) and Pilkington, Lowe, Foster, Robinson & Antonis (1966) have shown that this rise in plasma NEFA concentration is antagonised by P-adrenoceptor blockade using propranolol, but not by a-adrenoceptor blockade.…”

Section: Resultsmentioning

confidence: 99%

The effects of atenolol and propranolol upon lipolysis.

Deacon¹

1978

Brit J Clinical Pharma

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I The effects of selective and non-selective ,-adrenoceptor blockade upon plasma non-esterified fatty acid concentrations in the fasting state and following insulin stress have been studied in normal subjects. 2 Atenolol, propranolol and placebo were compared in a double-blind cross-over trial in eight normal subjects. 3 Atenolol and propranolol significantly lowered plasma non-esterified fatty acid concentrations by a similar degree in the fasting, non-stressed state. This finding suggests that ,B-adrenoceptors are involved in the control of basal lipolysis. 4 Following insulin-induced stress, lower plasma non-esterified fatty acid concentrations were observed with propranolol than with atenolol. This difference may be due to P2-adrenoceptor involvement in the stress mechanisms controlling lipolysis, or to the differences in the water-lipid solubility properties of these drugs.

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Section: Resultsmentioning

confidence: 99%

The effects of atenolol and propranolol upon lipolysis.

Deacon¹

1978

Brit J Clinical Pharma

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“…The hormonal responses to acute hypoglycemia observed in normal individuals (2,16,19,36,45) may not be the same as those of diabetic patients who have suffered repeated or prolonged episodes of hypoglycemia over many months or years. Most of the published cases of the Somogyi syndrome (5, 32,44, 50, 52), as well as our own cases 1-5 (8).…”

Section: Discussionmentioning

confidence: 98%

“…The response of the adrenal medulla to insulin-induced hypoglycemia was investigated by Wallace and Harlan (57) and by Goldfien et al (16) by measuring plasma levels of epinephrine in normal subjects after intramuscular injections of insulin. A 10-15-fold rise of plasma epinephrine levels was observed; elevated epinephrine levels persisted for 2 hr.…”

Section: Discussionmentioning

confidence: 99%

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Interaction of Endogenous Growth Hormone, Cortisol, and Catecholamines with Blood Glucose in Children with Brittle Diabetes Mellitus

Bruck

MacGillivray

1975

Pediatr Res

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“…The key hormonal switches involved, adrenal glucocorticoids [5] and catecholamines [6], are secreted as a hypoglycemic response. These hormones are also secreted in response to fasting [7].…”

Section: ) Entering the Fat-burning Statementioning

confidence: 99%