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Evidence has been presented by several investigators that functional capacity of the kidney in the premature and young infant is lower than in older children and adults. Schoenthal (1) using urea clearance, McCance and Young (2) urea and inulin clearances, Barnett (3) inulin clearance, and

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Hill-Baldes osmometer in the first series of cases, later with the Fiske osmometer.Methods for blood and serum analyses:\p=m-\blood was allowed to clot and was centrifuged under mineral oil; pH, cases 1 to 44, Cambridge Research model pH meter, at room temperature, using Rosenthal's2 correction for temperature; cases 45 to 59, Radiometer (Model PHM 4), pH meter with capillary glass electrode at 38 C; carbon dioxide content, Van Slyke manometric apparatus, using 0.2 ml serum; chloride, Van Slyke's modification of Sendroy's method;3 sodium and potassium, by flame photometer with internal standard of lithium nitrate; calcium, micromodification, using 0.5 ml of serum, of Roe and Kahn's method;4 phosphorus: Gomori's method;5 serum urea nitrogen, modified

Late diabetic complications are often related to vascular changes and formation of thrombi in the altered vasculature. Contributing factors to thrombosis susceptibility of diabetic patients include changes in clotting factors, platelets, and inhibition of fibrinolysis. We have measured various fibrinolytic inhibitors in the blood of diabetic children, diabetic pregnant women and their offspring, and healthy controls. Inhibitors studied included 1) fast (immediate) antiplasmin, 2) slow (progressive) antiplasmin, 3) alpha-2-macroglobulin, and 4) alpha-1-antitrypsin. It appears from our study that high fast-antiplasmin levels, and low or missing slow-antiplasmin levels are characteristic of diabetic patients and of newborn of diabetic mothers. The reason for high fast-antiplasmin levels is not clear: Levels are not connected with the age of the patient or duration of diabetes, and are not elevated in response to a fibrinolytic process (fibrin decomposition products could not be shown to be present in the serum of diabetic children). Alpha-2-macroglobulin was significantly higher and alpha-1-antitrypsin significantly lower in diabetic women than in controls. In the other groups of patients studied differences in these inhibitors from the appropriate control groups were not statistically significant.