Plasma Endothelin-1 Concentrations in Patients with Behçet' Disease

Ural, Ali Uğur; Yalçın, Atilla; Beyan, Cenǵiz; Işimer, A.; Bayhan, Hi̇kmet

doi:10.3109/03009749409099281

Cited by 19 publications

(17 citation statements)

References 27 publications

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“…These observations are supported by other studies as well. [2322149] It is not known whether elevated ET-1 levels are a direct result of its increased synthesis from injured vascular endothelial cells or whether its high concentrations may be responsible, along with other factors, for both vascular and articular complications in patients with BD. [22] One study attributed the increase of serum ET-1 levels in BD to increased secretion or leakage of this mitogen from injured vascular endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

2010

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Background:Some prominent features of Behçet’s disease (BD) are arterial and venous thromboses as a result of endothelial dysfunction. Hyperhomocysteinemia is responsible for vascular endothelial injury due to an increased frequency of thrombogenesis. Endothelin-1 (ET-1) is a vasoconstrictor whereas nitric oxide (NO) is an endothelial vasorelaxing peptide that is responsible for the inhibition of platelet adhesion.Aim:To evaluate serum levels of homocysteine (Hcy) and determine whether hyperhomocysteinemia is considered as a contributing risk factor for venous and arterial thromboses of BD, and to correlate serum levels of ET-1 and NO with disease activity.Materials and Methods:We measured serum levels of Hcy, ET-1, and nitrite (NO2−) in 25 patients who fulfilled the criteria of the International Study Group for BD, and compared them to those of 15 healthy control subjects. Levels of Hcy and ET-1 were measured by using enzyme-linked immunosorbent assay (ELISA), whereas serum nitrite (NO2−) levels were measured by using Griess reaction as an indicator for NO production. All the patients were screened for a history of venous thrombosis and subdivided into thrombotic and nonthrombotic subgroups according to their thrombotic history. Patients with BD were divided into two subgroups, active and inactive, according to their clinical and laboratory findings.Results:There were significant increases in serum levels of Hcy, ET-1, and nitrite in BD patients compared to those in controls. There was a significant increase in serum Hcy levels in thrombotic compared to nonthrombotic subgroups. Positive correlations were detected between the serum ET-1 and nitrite levels with disease activity in BD patients.Conclusion:Hyperhomocysteinemia may play some role in the development of venous and arterial thromboses in BD. Increased NO production might ave critical biological activities that are relevant to pathological events in the active period of the disease.

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Section: Discussionmentioning

confidence: 99%

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

2010

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“…The sample size was calculated by using the results of previous studies that investigated the levels of ADMA (10)(11)(12), and ET-1 (13)(14)(15) Results were presented as mean±SD, and † median±IQR. p values <0.05 accepted as statistically significant.…”

Section: Patients and Controlsmentioning

confidence: 99%

“…(27). Elevated ET-1 levels have been reported in inflammatory rheumatic diseases particularly in scleroderma (28), SLE (14), Behcet's disease (15) and RA (13) …”

Section: Patients and Controlsmentioning

confidence: 99%

Increased Levels of Asymmetric Dimethylarginine (ADMA) in Patients with Ankylosing Spondylitis

et al. 2009

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Objective Endothelial dysfunction is present in ankylosing spondylitis (AS). 05). Serum ADMA concentrations were also significantly higher in AS than in controls. Plasma levels of ET-1 did not differ between the groups (p>0.05). Comparison of three groups (conventional and anti-TNF treatment groups and controls) revealed that ADMA was significantly higher in the conventional treated AS than in controls. The levels of ADMA were not different between anti-TNF group and healthy subjects. Plasma ET-1 concentrations were similar between groups (p>0.05). Correlation analysis yielded significant correlations between ADMA, hsCRP, LDL cholesterol, HDL cholesterol and triglycerides (p<0.05

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“…Increasing evidence suggests that reactive oxygen species (ROS) produced by sites of endothelial inflammation and activated lymphocytes overwhelm the antioxidant defense systems, reacting with NO, decreasing the ability of vasodilatation and inhibiting thrombosis [67]. Moreover, the level of endothelin 1, another product of endothelial cells which antagonizes the effects of NO and might lead to thrombosis, was significantly higher in patients with BD [68].…”

Section: The Central Role Of Blood Vessel Endothelium In Vasculitis-amentioning

confidence: 99%

Thrombosis in vasculitic disorders−clinical manifestations, pathogenesis and management

Katz¹,

Brenner

Horowitz

2015

Thrombosis Research

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Plasma Endothelin-1 Concentrations in Patients with Behçet' Disease

Cited by 19 publications

References 27 publications

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

Increased Levels of Asymmetric Dimethylarginine (ADMA) in Patients with Ankylosing Spondylitis

Thrombosis in vasculitic disorders−clinical manifestations, pathogenesis and management

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