Thrombosis in vasculitic disorders−clinical manifestations, pathogenesis and management

Katz, Ofrat Beyar; Brenner, Benjamin; Horowitz, Netanel A.

doi:10.1016/j.thromres.2015.07.016

Cited by 9 publications

(7 citation statements)

References 85 publications

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“…Patients with EGPA had the highest rates of venous events relative to patients with MPA and GPA, but the lowest rates of arterial events. The risk was highest with active disease and around flares [52,54,55].…”

Section: Thrombosis and Radmentioning

confidence: 99%

“…Recent data suggest that arterial and venous thrombotic events may be a feature of small-vessel antineutrophil cytoplasmic antibody-associated vasculitis (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA) [51,52]. Specifically, GPA and MPA, and to a lesser extent EGPA, have been associated with an increased risk of ischemic heart disease, more cardiovascular events, and subclinical atherosclerosis affecting peripheral blood vessels [51,52]. A retrospective cohort study of 113 patients with AAV and matched controls found that the AAV group had more cardiovascular events over a 3.4-year follow-up, with a hazard ratio of 2.23 [53].…”

Section: Thrombosis and Radmentioning

confidence: 99%

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Hematological Manifestations among Patients with Rheumatic Diseases

Klein

Molad

2020

Acta Haematol

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Background: Rheumatic diseases have many hematological manifestations. Blood dyscrasias and other hematological abnormalities are sometimes the first sign of rheumatic disease. In addition, novel antirheumatic biological agents may cause cytopenias. Summary: The aim of this review was to discuss cytopenias caused by systemic lupus erythematosus and antirheumatic drugs, Felty’s syndrome in rheumatoid arthritis, and autoimmune hemolytic anemia, thrombosis, and thrombotic microangiopathies related to rheumatological conditions such as catastrophic antiphospholipid syndrome and scleroderma renal crisis. Key Message: The differential diagnosis of various hematological disorders should include rheumatic autoimmune diseases among other causes of blood cell and hemostasis abnormalities. It is crucial that hematologists be aware of these presentations so that they are diagnosed and treated in a timely manner.

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Section: Thrombosis and Radmentioning

confidence: 99%

Section: Thrombosis and Radmentioning

confidence: 99%

Hematological Manifestations among Patients with Rheumatic Diseases

Klein

Molad

2020

Acta Haematol

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“…La trombosis, inflamación y aterogénesis son eventos fisiopatológicos íntimamente relacionados y tanto las plaquetas como los leucocitos son sus principales efectores celulares. El contaje elevado de plaquetas puede reflejar aumento de la activación plaquetaria, proliferación megacariocítica y trombocitosis relativa (8). Además, los recuentos bajos de linfocitos parecen indicar que la alteración de la respuesta inmunitaria está asociada con resultante adversa en pacientes con trastornos cardiovasculares (9).…”

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Utilidad diagnóstica de la relación plaquetas/linfocitos en embarazadas con preeclampsia

Mejia-Montilla¹,

Reyna-Villasmil²,

Torres-Cepeda³

et al. 2021

RSOGV

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Objective: To establish the diagnostic utility of the platelet-lymphocyte ratio in pregnant women with preeclampsia. Methods: A case-control study was carried out at the Hospital Central “Dr. Urquinaona” Maracaibo, Venezuela. A total of 180 pregnant women were selected. Ninety preeclamptic women were included as the study group (group A) and a control group selected for their age and body mass index similar to the study group, which consisted of 90 healthy normotensive pregnant women (group B). The general characteristics, platelet-lymphocyte ratio values and diagnostic efficacy were determined. Results: Group A patients presented lower platelet and lymphocyte values compared to group B patients (p <0.001). However, no statistically significant differences were found in platelet-lymphocyte ratio between group A patients (115.2 ± 32.7) and group B patients (122.3 ± 23.8; p = 0, 0971). A cut-off value of the platelets-lymphocyte ratio of 117 presented a value below the curve of 0.57, the sensitivity of 47.8%, the specificity of 50.0%, the positive predictive value of 48.9%, and the negative predictive value of 52.2%, with a diagnostic accuracy of 48.9%. Conclusion: Platelet-lymphocyte ratio is not a useful tool in the diagnosis of preeclampsia, since patients with the syndrome present similar values to normotensive pregnant women. Keywords: Platelet-lymphocyte ratio, Preeclampsia, Diagnosis, Pregnancy.

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“…The development of endothelial damage and induction of microparticles (MPs) during active vasculitis were reported as possible factors for the appearance of thrombosis, alluding to the relation between vasculitis and disorders in hemostasis. 4 Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is associated with an increased frequency of venous thrombosis. In this case, hypercoagulability was reported to be due to C5a-primed neutrophils, leading to the generation of neutrophil tissue factor (TF) expressing MPs and neutrophil extracellular traps (NETs), all of which are promoters of coagulation activation.…”

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confidence: 99%

Hemostasis in Allergy

Vadasz

Toubi

2018

Semin Thromb Hemost

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The involvement of the hemostatic system in immune-mediated inflammation is widely reported. Many coagulation factors play a role in the pathogenesis of autoimmune diseases, such as systemic vasculitis and systemic lupus erythematosus. Hemostatic disorders are also involved in asthma and chronic spontaneous urticaria (CSU). Factor XIIa (FXIIa) was one of the first coagulation factors implicated in inducing both humoral and cellular responses and is therefore considered a prime new therapeutic target in immune-mediated inflammation. The involvement of coagulation factors, such as tissue factor and fibrinogen, in the pathogenesis of asthma has been reported. The finding of platelet activation in asthma also indicates a link between bronchial inflammation and hemostasis. The pathogenesis of mast cell degranulation and CSU was also shown to be associated with the activation of hemostatic factors such as fibrinogen and FXIIa. Increased plasma levels of D-dimer have been widely reported as a biological marker for the duration and severity of CSU. In addition, endothelial-induced cell activation by the kallikrein-high molecular weight complex and the release of heat shock protein 90 was shown to be involved in mast cell degranulation disorders. In this narrative review, the authors aim to summarize the role of hemostasis in inflammation, asthma, and CSU by focusing on the increasing information linking hemostatic factors and immune-mediated disorders.

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Thrombosis in vasculitic disorders−clinical manifestations, pathogenesis and management

Cited by 9 publications

References 85 publications

Hematological Manifestations among Patients with Rheumatic Diseases

Hematological Manifestations among Patients with Rheumatic Diseases

Utilidad diagnóstica de la relación plaquetas/linfocitos en embarazadas con preeclampsia

Hemostasis in Allergy

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