Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia

Kao, Shang Jyh; Chuang, Chun Yi; Tang, Chih Hsin; Lin, Chien Huang; Bien, Mauo Ying; Yu, Ming Chih; Bai, Kuan Jen; Yang, Shun Fa; Chien, Ming Hsien

doi:10.1515/cclm-2013-0638

Cited by 35 publications

(29 citation statements)

References 32 publications

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“…In parallel to the literature, high Endocan levels were shown to be related with the development of VAP in the present study. Similar to the literature, it was also determined that WBC, PCT, and CRP levels were correlated with the development of VAP [15,17].…”

Section: Discussionsupporting

confidence: 71%

“…In addition, it is also mentioned in these studies that Endocan can be a diagnostic and prognostic factor in pulmonary diseases. In the study by Kao et al., it was revealed that plasma Endocan level was more useful than CRP and WBC counts in assessing severity of the community‐acquired pneumonia [15]. Likewise, Endocan levels after the major trauma were related with development of the acute lung injury [14] and Endocan levels in Acute Respiratory Distress Syndrome were high [25].…”

Section: Discussionmentioning

confidence: 99%

“…Endocan levels were found to be high in many diseases particularly in lung [8], renal cancers [9–11], preeclampsia [12,13], in which Endocan could be used as the biomarker. It is also mentioned that Endocan may have a diagnostic and prognostic role in pulmonary diseases [14,15]. In the study by Seo K et al., it was stated that it took about three hours to measure the serum Endocan level by ELISA and Endocan can be widely used as a screening tool for bacteremia by shortening the measurement time and reducing the cost [16].…”

Section: Introductionmentioning

confidence: 99%

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Can endocan be a new biomarker in ventilator‐associated pneumonia?

Küpeli

Salcan

Kuzucu

et al. 2018

The Kaohsiung J of Med Scie

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Ventilator‐Associated Pneumonia (VAP) is a hospital‐acquired bacterial infection with high incidence and mortality rate. The aim of this study is to investigate the correlation between the Endocan level and development of VAP and whether or not this correlation was correlated with the clinical findings. Demographic data, white blood cell (WBC) count, procalcitonin (PCT), c‐reactive protein (CRP), and fever levels of 60 patients were recorded in serial measurements for 5 days. When there was the presence of fever or elevated Endocan, alveolar lavage culture was taken and chest radiographies were taken. Correlations of the Endocan levels with the culture results and laboratory values were examined. The rate of VAP was found as 10.4/1000 mechanical ventilator days. Endocan levels were significantly higher in patients with VAP (p < 0.05). However, there was no significant difference among PCT, WBC, CRP measurements (p > 0.05). No correlation was found between Endocan levels and PCT, WBC and CRP levels in those with VAP (p > 0.05). A significant correlation was found between the Endocan level and the elevated fever 24 h later (p:0.001). The serum Endocan level on the day 3 had a specificity of 73.3%, a sensitivity of 68.9%, positive predictive value of 44%, and negative predictive value of 88.5% at the cut off level of 9.17 ng/mL. In this study, it was determined that high Endocan levels were associated with the development of VAP. The present study suggested that Endocan can be used as a screening tool for the development of VAP. Clinical Trials.gov ID NCT02916277.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Can endocan be a new biomarker in ventilator‐associated pneumonia?

Küpeli

Salcan

Kuzucu

et al. 2018

The Kaohsiung J of Med Scie

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“…In their study, Kao et al attempted to evaluate endocan’s usefulness in differentiating healthy individuals from patients with pulmonary infections 73. More specifically, endocan levels were measured in 82 hospitalized patients with community-acquired pneumonia (CAP) and compared to those of healthy controls.…”

Section: Endocan and The Respiratory Systemmentioning

confidence: 99%

Endocan and the respiratory system: a review

Kechagia¹,

Papassotiriou²,

Gourgoulianis³

2016

COPD

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Endocan, formerly called endothelial cell-specific molecule 1, is an endothelial cell-associated proteoglycan that is preferentially expressed by renal and pulmonary endothelium. It is upregulated by proangiogenic molecules as well as by pro-inflammatory cytokines, and since it reflects endothelial activation and dysfunction, it is regarded as a novel tissue and blood-based relevant biomarker. As such, it is increasingly being researched and evaluated in a wide spectrum of healthy and disease pathophysiological processes. Here, we review the present scientific knowledge on endocan, with emphasis on the evidence that underlines its possible clinical value as a prognostic marker in several malignant, inflammatory and obstructive disorders of the respiratory system.

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“…Kao et al [12] reported in a recent study that endocan was reliable in evaluating the severity of community-acquired pneumonia. Güzel et al [13] found a correlation between plasma endocan levels and thromboembolism.…”

Section: Introductionmentioning

confidence: 99%

Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study

Perrotti¹,

Chenevier‐Gobeaux

Ecarnot³

et al. 2017

Cardiorenal Med

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Objectives: This pilot study aimed to evaluate the relevance of endocan plasma levels for predicting pulmonary infection after cardiac surgery in patients with chronic kidney disease (CKD). Methods: Serum collected in a previous prospective cohort study (from 166 patients with preoperative CKD who underwent cardiac surgery) was used. Five patients with postoperative pulmonary infection were compared with 15 randomly selected CKD patients with an uneventful outcome. Blood samples were tested at 4 time points (preoperatively and 6, 12, and 24 h after the end of surgery). Endocan, procalcitonin, and C-reactive protein plasma levels were compared between the two groups. Results: At 6 h, the patients with pulmonary infection had significantly higher levels of endocan than the patients without pulmonary infection (24.2 ± 15.6 vs. 6.4 ± 3.2 ng/mL; p = 0.03). A receiver operating characteristic curve analysis showed 80% sensitivity and 100% specificity for endocan to predict pulmonary infection (area under the curve 0.84), with a cutoff value of 15.9 ng/mL. The time saved by assessment of the endocan dosage compared to a clinical diagnosis of pulmonary infection was 47 h. Conclusion: This pilot study showed that a specific study to assess the link between endocan plasma levels and pulmonary infection after cardiac surgery in CKD patients is of potential utility.

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Plasma endothelial cell-specific molecule-1 (ESM-1) in management of community-acquired pneumonia

Abstract: Plasma levels of ESM-1 may be able to play a role in the diagnosis and clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.

Cited by 35 publications

References 32 publications

Can endocan be a new biomarker in ventilator‐associated pneumonia?

Can endocan be a new biomarker in ventilator‐associated pneumonia?

Endocan and the respiratory system: a review

Relevance of Endothelial Cell-Specific Molecule 1 (Endocan) Plasma Levels for Predicting Pulmonary Infection after Cardiac Surgery in Chronic Kidney Disease Patients: The Endolung Pilot Study

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