Endocan  and the respiratory system: a review

Kechagia, Maria; Papassotiriou, Ioannis; Gourgoulianis, Konstantinos

doi:10.2147/copd.s118692

Cited by 44 publications

(42 citation statements)

References 84 publications

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“…ESM1 protein, also known as endocan, is a dermatan sulfate proteoglycan which is primarily expressed in ECs of vascular tissues including capillaries and arterioles but can also be found in the ECs of other tissues such as human lung and kidney . Its gene expression is regulated by cytokines, indicating its possible implication in endothelium‐based disorders . In addition, in recent studies, ESM1 has been identified as a specific biomarker of tip cells during angiogenesis as well as a simultaneous target and modulator of VEGF signaling in ECs .…”

Section: Discussionmentioning

confidence: 99%

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling

et al. 2018

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The mortality rate for (cardio)‐vascular disease is one of the highest in the world, so a healthy functional endothelium is of outmost importance against vascular disease. In this study, human induced pluripotent stem (iPS) cells were reprogrammed from 1 ml blood of healthy donors and subsequently differentiated into endothelial cells (iPS‐ECs) with typical EC characteristics. This research combined iPS cell technologies and next‐generation sequencing to acquire an insight into the transcriptional regulation of iPS‐ECs. We identified endothelial cell‐specific molecule 1 (ESM1) as one of the highest expressed genes during EC differentiation, playing a key role in EC enrichment and function by regulating connexin 40 (CX40) and eNOS. Importantly, ESM1 enhanced the iPS‐ECs potential to improve angiogenesis and neovascularisation in in vivo models of angiogenesis and hind limb ischemia. These findings demonstrated for the first time that enriched functional ECs are derived through cell reprogramming and ESM1 signaling, opening the horizon for drug screening and cell‐based therapies for vascular diseases. Therefore, this study showcases a new approach for enriching and enhancing the function of induced pluripotent stem (iPS) cell‐derived ECs from a very small amount of blood through ESM1 signaling, which greatly enhances their functionality and increases their therapeutic potential. S tem C ells 2019;37:226–239

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Section: Discussionmentioning

confidence: 99%

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling

et al. 2018

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“…It is secreted by vascular endothelial cells, and also expression of endocan is regulated by a number of proangiogenic factors such as vascular endothelial growth factor as well as cytokines. 9 – 11 , 36 Previous studies mentioned that endocan not only plays a role in the inflammatory process but also plays a role in the vascular damage and endothelium-dependent pathological disorders. Therefore, it may represent a novel endothelial cell dysfunction marker.…”

Section: Discussionmentioning

confidence: 99%

Serum endocan levels in patients with stable COPD

Pıhtılı

Bingöl

Kıyan

2018

COPD

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BackgroundEndothelial cell specific molecule-1, also called as endocan, is a dermatan sulfate proteoglycan, which is expressed by endothelial cells in alveolar walls of the lung and kidney. High endocan levels are found associated with endothelial dysfunction and inflammation. We hypothesize that endocan level is also high in COPD due to systemic inflammation and endothelial dysfunction. We aimed to investigate the expression of endocan in patients with stable COPD.Material and methodsThe study included patients with COPD and control subjects. COPD patients were classified according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 criteria. Demographics, body mass index, smoking history, and comorbidities were recorded. Endocan levels of COPD patients and controls were compared.ResultsTotally, 88 subjects (47 stable COPD patients, 41 controls) were evaluated. Endocan levels were significantly higher in COPD patients than control group (860.1±259.8 vs 647.3±316.9 pg/mL, P=0.001). There was no relationship between GOLD COPD categories and endocan levels. Also endocan levels were similar between COPD patients with or without hypoxemia.ConclusionSerum endocan level was significantly higher in patients with stable COPD. Further studies should be performed to better understand the relationship between endocan and COPD.

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“…It is preferentially expressed in vascular endothelial cells in the lung and kidney, and its overexpression can be seen in some neonatal and proliferating tissues as well as some tumors. 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

The association of elevated circulating endocan levels with lung function decline in COPD patients

Dai

Chen

et al. 2018

COPD

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BackgroundEndocan is thought to be a novel inflammatory marker that is associated with a variety of inflammatory diseases. However, its role in the pathogenesis of COPD remains unclear. This study aims to explore the potential role of endocan in COPD.MethodsIn total, 27 healthy volunteers, 55 COPD patients and 36 acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients were included in the study. Basic demographic characteristics, clinical features and blood samples were collected. Magnetic luminex screening assays were used to detect the concentration of endocan, Fas and Fas ligand (Fas-L) in plasma. Differences between groups were compared using an Independent sample t-test, Welch’s t-test, chi-squared test and Wilcoxon rank sum test. The correlations of plasma endocan with lung function parameters, Fas and Fas-L were analyzed by Pearson’s partial correlation test (adjusted for age, gender, body mass index and smoking history) and multiple linear regression.ResultsPlasma endocan levels in COPD patients were significantly higher than those in healthy volunteers (509.7±18.25 pg/mL vs 434.8±18.98 pg/mL (P=0.0124)), and AECOPD patients had the highest levels of endocan (524.7±27.18 pg/mL). Correlation analysis showed that circulating endocan had a negative correlation to FEV1/FVC, FEV1/predictive and FVC (adjusted r=−0.213, P=0.03; adjusted r=−0.209, P=0.034; and adjusted r=−0.300, P=0.002, respectively), and had a positive correlation to Fas (adjusted r=0.280, P=0.004).ConclusionOur study shows that elevated circulating endocan levels are associated with reduced lung ventilation function in COPD and AECOPD patients. In addition, endocan may influence apoptosis in COPD, suggesting that endocan may play a role in COPD pathogenesis.

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Endocan and the respiratory system: a review

Cited by 44 publications

References 84 publications

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling

Enhanced Function of Induced Pluripotent Stem Cell-Derived Endothelial Cells Through ESM1 Signaling

Serum endocan levels in patients with stable COPD

The association of elevated circulating endocan levels with lung function decline in COPD patients

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