Plasma cytokines in obese women with polycystic ovary syndrome, before and after metformin treatment

Jakubowska, Joanna; Bohdanowicz-Pawlak, Anna; Milewicz, Andrzej; Szymczak, J; Bednarek-Tupikowska, Grażyna; Demissie, Marek

doi:10.1080/09513590802128968

Cited by 54 publications

(60 citation statements)

References 39 publications

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“…The association of IR and hyperinsulinemia of PCOS with elevation of various cytokines such as IL-4, IL-6, TNF-a, and their alteration after treatment with insulin sensitizers is well established (9,10). Elevated fasting insulin and HOMA-IR, indicative of significantly higher IR in both of our PCOS and non-PCOS sub-groups of CLT girls when compared to controls, may indicate some pathogenic link between autoimmunity and IR (12,13).…”

Section: Discussionmentioning

confidence: 99%

“…Women with PCOS have been demonstrated to have elevated cytokines like tumour necrosis factor-a (TNF-a) and IL-6 concentrations independent of obesity, and these alterations in serum inflammatory markers in PCOS are unrelated to PPAR-g variants (9). It has been demonstrated that the therapy with metformin in PCOS leads to an increase in plasma adiponectin and TNF-a but not plasma IL-6 and C reactive protein (CRP) (10). Some authors demonstrated a high prevalence of autoimmune thyroiditis in PCOS women suggesting a potential pathogenic link with autoimmunity/sub-inflammatory cascade (11).…”

Section: Introductionmentioning

confidence: 99%

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High prevalence of polycystic ovary syndrome characteristics in girls with euthyroid chronic lymphocytic thyroiditis: a case–control study

Ganie

Marwaha

Aggarwal

et al. 2010

European Journal of Endocrinology

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Objective: The aim was to find the prevalence of polycystic ovary syndrome (PCOS) phenotype in adolescent euthyroid girls with chronic lymphocytic thyroiditis (CLT). Design: This was a prospective case-control study as part of an ongoing community-wide thyroid survey in Indian schools. Methods: One hundred and seventy-five girls with euthyroid CLT and 46 age-matched non-CLT girls underwent clinical, biochemical, hormonal, and ultrasonographic evaluation for diagnosis of PCOS by Rotterdam 2003 criteria. All subjects underwent serum sampling for LH, FSH, testosterone, DHEAS, free thyroxine, TSH, and anti-thyroid peroxidase (TPO) antibodies. Oral glucose tolerance test (OGTT) was undertaken for plasma glucose and insulin. Results: Significantly higher prevalence of PCOS was noted in girls with euthyroid CLT when compared to their control counterparts (46.8 vs 4.3%, PZ0.001). The CLT girls had higher body mass index, waist circumference, and systolic blood pressure (PZ0.001). Mean number of menstrual cycles/year was 8.4G3.5 vs 10.1G1.4, and mean Ferriman-Gallwey score was 11.9G3.5 vs 3.0G2.4 (PZ0.001) in cases versus controls respectively. The fasting and postprandial glucose and serum cholesterol were also higher in the cases (PZ0.001). Homeostasis model assessment-insulin resistance was 4.4G4.2 vs 2.3G2.7 in the cases versus controls (PZ0.001). Conclusion: Higher prevalence of PCOS characteristics in euthyroid CLT girls when compared to controls suggest possible role of autoimmune phenomenon in the etiopathogenesis of PCOS. Further studies are required to understand the pathogenic link between these two disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

High prevalence of polycystic ovary syndrome characteristics in girls with euthyroid chronic lymphocytic thyroiditis: a case–control study

Ganie

Marwaha

Aggarwal

et al. 2010

European Journal of Endocrinology

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“…[32][33][34][35][36][37] We attribute these differences to several factors, such as the diagnostic criterion for the syndrome, the presence of CV risk factors and the presence of obesity itself. In this study we sought to select such a group of women that would avoid such bias and, through the employment of a select statistical method, to separate the confounding effect of PCOS and obesity.…”

Section: Discussionmentioning

confidence: 99%

Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors

Barcellos¹,

Rocha²,

Hayashida³

et al. 2015

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obJectIve: the aim of this study was to evaluate the influence of polycystic ovary syndrome (pcos) and obesity on circulating markers of low-grade inflammation-tumor necrosis factoralpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)-in young women without major cardiovascular (cv) risk factors (diabetes, dyslipidemia and arterial hypertension). desIGn: twenty-five young women with pcos and 23 eumenorrheic women without major cv risk factors and matched for body mass index (bmI) were studied. they were subdivided according to bmI and pcos status and comparisons were made between the pcos and control groups, regardless of bmI, and between the obese and Lean groups, regardless of the presence of PCOS. RESULTS: Levels of TNF-α, IL-6 and hsCRP were similar between the pcos group and the control group (2.1 vs 1.9 pg/ml, p=0.397, 3.8 vs 5.7 pg/ml, p=0.805 and 0.9 vs 0.5 ng/ml, p=0.361, respectively). Levels of TNF-α were similar between the obese group and the lean group (2.1 vs 1.9 pg/ml, p=0.444). Levels of IL-6 and hscrp were higher in the obese group than in the lean group (8.7 vs 2.0, p <0.001 and 1.4 vs 0.2 ng/ml, p <0.001, respectively). concLusIon: obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cv risk factors.

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“…In fact, obesity, predominantly abdominal, is recognized as an important determinant of metabolic risk in these patients (Azziz et al, 2004;Spritzer and Wiltgen, 2007). In PCOS, elevated leptin serum levels have been associated with amount of adipose tissue, waist circumference, insulin resistance, and hyperandrogenemia (Spritzer et al, 2001;Carmina et al, 1999Carmina et al, , 2005, while adiponectin levels have been reported to be decreased (Ardawi and Rouzi, 2005;EscobarMorreale, 2006;Jakubowska et al, 2008;Carmina et al, 2005Carmina et al, , 2009 or unchanged (Orio et al, 2003;Sprangler et al, 2004;Gulcelik et al, 2006). In this paper, we briefly review the emerging evidence linking adipose tissue expression of leptin and adiponectin and serum adipokine levels in women with PCOS.…”

Section: Introductionmentioning

confidence: 99%

Association between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome

Lecke¹,

Morsch²,

Spritzer³

2013

Genet. Mol. Res.

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ABSTRACT. We reviewed emerging evidence linking serum levels and adipose tissue expression of leptin and adiponectin in women with polycystic ovary syndrome (PCOS). Previous data obtained by our group from a sample of overweight/obese PCOS women and a control sample of normal weight controls, both stratified by BMI, were reanalyzed. Circulating levels of leptin and adiponectin were determined by commercially available enzyme-linked immunosorbent assays. Adipose tissue total RNA was reserve-transcripted into complementary DNA samples, which were used as templates for quantitative real-time PCR amplification. Positive correlations were found between serum and mRNA levels for both leptin (r = 0.321; P = 0.005) and adiponectin (r = 0.266; P = 0.024). Deter-©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 4292-4296 (2013) Adipose tissue expression in PCOS 4293 mination of leptin and adiponectin serum levels could serve as an indirect method to assess adipocyte production, since leptin and adiponectin are predominantly produced by subcutaneous adipocytes in women.

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Plasma cytokines in obese women with polycystic ovary syndrome, before and after metformin treatment

Cited by 54 publications

References 39 publications

High prevalence of polycystic ovary syndrome characteristics in girls with euthyroid chronic lymphocytic thyroiditis: a case–control study

High prevalence of polycystic ovary syndrome characteristics in girls with euthyroid chronic lymphocytic thyroiditis: a case–control study

Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors

Association between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome

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