Plasma cystatin C and neutrophil gelatinase-associated lipocalin in relation to coronary atherosclerosis on intravascular ultrasound and cardiovascular outcome: Impact of kidney function (ATHEROREMO-IVUS study)

Abstract

Mild-to-moderate kidney dysfunction modifies the relationship between CysC and high-risk coronary lesions. This has not been established before, and offers an explanation for the difference in findings between experimental and epidemiologic studies.

Associations of 26 Circulating Inflammatory and Renal Biomarkers with Near-Infrared Spectroscopy and Long-term Cardiovascular Outcome in Patients Undergoing Coronary Angiography (ATHEROREMO-NIRS Substudy)

“…In our previous reports on the ATHEROREMO-IVUS study [ 8 – 12 ], levels of CRP, ferritin, RANTES, TNF-α, IL-10, cystatin C, and NGAL were associated with IVUS-VH-derived plaque burden in the full cohort. Additionally, IL-10, cystatin C, and NGAL were associated with IVUS-VH-derived thin-cap fibroatheroma (VH-TCFA) lesions.…”

“…This study design was chosen based on the hypothesis that such a non-stenotic segment reflects coronary wall pathophysiology in the larger coronary tree [ 13 •]. This assumption, on its part, was based on the fact that ex vivo, as well as in vivo, studies in patients with myocardial infarction, have demonstrated presence of TCFA (as assessed by IVUS) located elsewhere than the culprit lesion or even culprit artery [ 8 – 12 ]. In fact, we were subsequently able to confirm this hypothesis, by demonstrating that NIRS imaging characteristics of the non-culprit artery are associated with increased risk of MACE [ 6 ••].…”

“…Blood biomarkers may carry potential to detect vulnerable plaques in an early stage and in a non-invasive manner. Among others, biomarkers of inflammation (such as acute phase proteins, cytokines, and chemokines) and renal markers have strongly been implicated in the atherosclerotic process and in the occurrence of coronary events [ 7 – 12 ]. Currently, to the best of our knowledge, there are no data available on the associations between circulating biomarkers and NIRS measurements.…”

Prognostic value of cystatin C in relation to other markers of renal function in early prediction of hospital mortality and major cardiac adverse events in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention

“…Cystatin C je přirozeně produkován také kardiomyocyty, jeho produkce vzrůstá v závislosti na působení ischemie, hypoxie a oxidačním stresu [2,11,15]. Díky ovlivnění proteázové aktivity má cystatin C také úlohu v regulaci zánětlivé odpovědi, procesu aterogeneze a destabilizaci ateromového plátu [10,13,15,16].…”

Evolution of renal function and predictive value of serial renal assessments among patients with acute coronary syndrome: BIOMArCS study

“…However, even if they are on optimal therapy they will still have poorer prognosis [7]. Renal dysfunction is associated with coronary atherosclerosis, including higher coronary plaque burden, plaques containing greater necrotic core and more dense calcium, as well as with abnormalities of cardiac muscle, including left ventricular hypertrophy, dilated cardiomyopathy, and systolic dysfunction [8][9][10]. Several studies have shown that specific comorbidities such as hypertension, diabetes, and dyslipidemia, contribute both to cardiovascular and renal damage [11,12].…”