Associations of 26 Circulating Inflammatory and Renal Biomarkers with Near-Infrared Spectroscopy and Long-term Cardiovascular Outcome in Patients Undergoing Coronary Angiography (ATHEROREMO-NIRS Substudy)

Abstract

Purpose of ReviewThe purpose of this study was to investigate the association of 26 inflammatory biomarkers (acute phase proteins, cytokines, chemokines) and renal markers with coronary lipid core burden index (LCBI) assessed by near-infrared spectroscopy (NIRS) imaging, as well as the association of these biomarkers with long-term cardiovascular outcome.Recent FindingsNIRS-derived LCBI has recently been shown to be an independent predictor of major adverse cardiac events (MACE). However, studies on the association between circulating biomarkers and NIRS-derived characteristics have not yet been performed.SummaryBetween 2008 and 2011, 581 patients underwent diagnostic coronary angiography or percutaneous coronary intervention for stable angina pectoris or acute coronary syndrome (ACS). NIRS of a non-culprit vessel was performed in a subset of 203 patients. In multivariable analyses, TNF-α tended to be associated with higher LCBI (beta 0.088 ln (pg/ml) increase per unit LCBI; 95% CI 0.000–0.177, p = 0.05) after adjustment for clinical characteristics. However, this association did not persist after Bonferroni correction (statistical threshold 0.0019). Major adverse cardiac events (MACE) were registered in 581 patients during a median follow-up time of 4.7 years (IQR: [4.2–5.6] years). After adjustment for clinical characteristics and Bonferroni correction, IL-8 (HR 1.60; 95% CI [1.18–2.17] per ln (pg/ml), p = 0.002) was borderline associated with MACE and significantly associated with all-cause mortality or ACS (HR 1.75; 95% CI [1.24–2.48] per ln (pg/ml), p = 0.0015). In conclusion, we found that IL-8 was independently associated with clinical outcome, but altogether, the multiplex panel we investigated here did not render a useful blood biomarker of high LCBI.Electronic supplementary materialThe online version of this article (10.1007/s11883-018-0752-8) contains supplementary material, which is available to authorized users.

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“…Clinically healthy obese people might tend to have higher degrees of B2MG than normal-weight people [35]. Moreover, higher B2MG was correlated with a higher occurrence of major adverse cardiac events [36]. And B2MG as a mediator had been linked to the diet and incident cardiovascular disease, also including all-cause mortality [37].…”

Serum IL-38 Level Was Associated with Incidence of MACE in the STEMI Patients

“…[5][6][7] Furthermore, previous studies have reported that pro-inflammatory factors can be used to predict offender plaque characteristics and adverse cardiovascular events after hospital discharge in patients with STEMI. [8][9][10] It was found that TNF-α expression in monocytes is highly correlated with plaque rupture, and TNF-α can be used to predict the occurrence of plaque rupture. 11 Evidence suggested that the IL-1β concentration in STEMI at admission was association with the risk of mortality and recurrent MACE, the increase of IL-1β concentration was the independent predictor of MACE.…”