Plasma CRP, apolipoprotein A-1, apolipoprotein B and Lp(a) levels according to thyroid function status

Lee, Won Young; Suh, Jung-Yul; Rhee, Eun-Jung; Park, Jeong-Sik; Kim, Sun-Woo

doi:10.1016/j.arcmed.2004.08.003

Cited by 72 publications

(64 citation statements)

References 29 publications

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“…Hyperthyroid subjects also present with lower serum total cholesterol levels, with both LDL and HDL fractions reported to be reduced (Scottolini et al, 1980;Muls et al, 1982;Lee et al, 2004). Regarding changes in serum triglyceride levels, for this group of patients no consistency can be found because elevated, reduced, and unaltered levels have been reported (Tulloch et al, 1973;Muls et al, 1982;Friis and Pedersen, 1987).…”

Section: B Thyroid Hormone Receptor Actionmentioning

confidence: 67%

Nuclear Receptors and Their Selective Pharmacologic Modulators

et al. 2013

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Section: B Thyroid Hormone Receptor Actionmentioning

confidence: 67%

Nuclear Receptors and Their Selective Pharmacologic Modulators

et al. 2013

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“…However, Lee et al, observed no significant differences in serum Lp(a) levels in different thyroid function groups [27]. Although there are contradictory data on the fluctuations in Lp(a) levels, some authors [18,19] think that they are affected by thyroid function, and several others think that they are unaffected [17,20,26].…”

Section: Methodsmentioning

confidence: 94%

Relationship between Lipoprotein(a) and Thyroid Hormones in Hypothyroid Patients

Kaliaperumal

William

Selvam

et al. 2014

JCDR

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Background and Objective: Changes in plasma lipid con cen trations are well known metabolic consequences of thyroid dysfunction. The alterations are most prominent in hypothyroidism which is typically associated with pronounced hypercholesterolaemia and frequently with moderate hyper triglyceridaemia. In cases of hypothyroidism, how the serum Lp(a) levels are influenced by thyroid hormone remains unknown and contradictory results on the effect of thyroid hormone on serum Lp(a) levels have been reported. There is substantial evidence to suggest that elevated serum Lp(a) levels contribute significantly to the development of CHD. The present study was designed to determine the lipoprotein(a) [Lp(a)], lipid profile and thyroid hormone levels in newly diagnosed hypothyroid patients and to find any correlation that existed between Lp(a) and other parameters.

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“…A P value < 0.05 was considered statistically significant. 6,7,8 dyslipidemia But in patients with overt hypothyroidism, activity of HMG-CoA reductase tends to decrease while TC 9,10 and LDL-C levels are increased. This can be explained as increased thyroid hormones leads to decresedcatabolism of 11,12 LDL and IDL Hyperthyroidism canalso be the contributory factor that may cause unexpected improvement of lipid profile 13 in hyperlipidemic patients Since, hyperthyroidism whether overt or subclinical , there is decrease in LDLand HDL cholesterol resulting enhanced oxidation of LDL that depends 14 on level of FT4.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of Lipid Abnormality among Thyroid Disorder Patients in Ucms-Th, South Western Region

Gautam

Jayan

Jha

et al. 2018

J Univ Coll Med Sci

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INTRODUCTION:Hypothyroidism is the most common cause of secondary dyslipidemia. Thus, thyroid function test should be carried out before starting any hypolipidemic drugs. Even among thyroid disorder, hypothyroidism is more associated with cardiovascular and associated problems and if not detected earlier, it leads to severe clinical consequences. Our study assesses the frequency and spectrum of dyslipidemia in various types of thyroidal illness in the population residing in south western part of Nepal. MATERIALS AND METHODS:This is a cross sectional study carried out in suspected thyroid disorder patients (n=276) and categorized as Euthyroidism (n=55), Subclinical Hypothyroidism (n=89), Primary Hypothyroidism (n=122) and Primary Hyperthyroidism (n=10) patients and to see the association with lipid profiles in the Department of Biochemistry, Universal College of Medical Sciences Teaching Hospital, Bhairahawa Nepal. Serum fT / fT4 and TSH estimations were carried out by competitive 3 ELISA method and Sand-wich double antibody ELISA method respectively using commercially supplied reagents (Human, Germany). The criteria for dyslipidemia was obtained by National Cholesterol Education Expert Panel/ Adult Treatment Protocol III (NCEP/ATPIII). RESULTS:Out of 276 cases the dyslipidemia was observed in 183 cases (66.30%).The dyslipidemia was mostly associated with primary hypothyroidism (55.07%) followed by Subclinical Hypothyroidism (38.04%) than Euthyroid (5.79 %) and Primary Hyperthyroidism (3.62 %) respectively. Out of all cases, the spectrum of dyslipidemia was mostly observed for decreased HDL (18.5 %) followed by increased TG (10.1 %). Moreover, it is significantly differ in relation in HDL (p=0.009), TG/HDL (p=0.02) and Non-HDL/HDL (p=0.033) where as non significant as compared to other lipid profile in different groups. CONCLUSION:Our study revealed the close association of thyroidal illness with dyslipidemia with increased TG, low HDL, increased TG/HDL and Non-HDL/HDL. The increased TG/HDL and/or Non-HDL/HDL could be better indicator than single lipid abnormality which needs to be ascertained prospectively in large population.

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Plasma CRP, apolipoprotein A-1, apolipoprotein B and Lp(a) levels according to thyroid function status

Cited by 72 publications

References 29 publications

Nuclear Receptors and Their Selective Pharmacologic Modulators

Nuclear Receptors and Their Selective Pharmacologic Modulators

Relationship between Lipoprotein(a) and Thyroid Hormones in Hypothyroid Patients

Spectrum of Lipid Abnormality among Thyroid Disorder Patients in Ucms-Th, South Western Region

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