Plasma cortisol, testosterone, androstenedione and luteinizing hormone (LH) in a non-competitive marathon run

Dessypris, A.; Kuoppasalmi, Kimmo; Adlercreutz, Herman

doi:10.1016/0022-4731(76)90161-8

Cited by 172 publications

(92 citation statements)

References 30 publications

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“…In previous studies, surgical [2,29,36,50], physical [11,13,28,38,39], and social stress [43][44][45] resulted in decreased plasma levels of gonadotropins, inhibin and/or testosterone in humans, male primates and rats. However, in the present study, plasma levels of inhibin significantly increased on day 3 after vasectomy.…”

Section: Discussionmentioning

confidence: 86%

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

et al. 2011

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The present study was undertaken to clarify changes in secretions of FSH, LH, inhibin and testosterone, and sperm motility after bilateral vasectomy in adult male rats. Bilateral vasectomy was created surgically (treated group) and intact rats were used as control (control group). On days 3,5,7,14,30, 60, and 90 after surgery, plasma concentrations of FSH, LH, inhibin, and testosterone were measured by radioimmunoassay, and sperm motility characteristics were measured by computer-assisted sperm analysis (CASA). The results show that weights of epididymides significantly increased in vasectomized rats as compared to control rats. Histologically, damage to spermatogenesis was observed in vasectomized rats. Multinucleated giant cells were observed in the lumen of some seminiferous tubules, and there were degenerative spermatids in the epididymides of vasectomized rats. Plasma levels of LH, FSH, and testosterone only decreased on day 3 after vasectomy; however, plasma levels of ir-inhibin significantly increased on day 3 after vasectomy. In addition, the sperm motility parameters, straight-line velocity, curvilinear velocity, deviation of the sperm head from the mean trajectory and the maximum amplitude of lateral head displacement were decreased from day 60 after vasectomy. These results suggest that vasectomy reduces sperm motility starting from day 60 after vasectomy, and early bilateral vasectomy does not strongly affect the endocrine function of the testis, though it may result in damage to spermatogenesis in vasectomized rats.

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Section: Discussionmentioning

confidence: 86%

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

et al. 2011

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“…However, concentrations of ir-inhibin in the testicular interstitial fluid were significantly higher than in the control group until 3 days after the operation. Surgical [40,41], physical [42][43][44][45][46][47], and social [48][49][50] stress can result in an acute decline in plasma l e v e l s o f g o n a d o t r o p i n s , i n h i b i n , a n d / o r testosterone in adult male rats [51,52]. However, it must be pointed out that the expected reciprocal relationship between plasma FSH and inhibin B levels following early cryptorchidism in mature rats is clear.…”

Section: Discussionmentioning

confidence: 99%

Effects of Experimental Cryptorchidism on Sperm Motility and Testicular Endocrinology in Adult Male Rats

Ren

Medan

Ozu

et al. 2006

Journal of Reproduction and Development

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Abstract. The effect of induced cryptorchidism on testicular function and sperm motility was investigated. Bilateral cryptorchidism was created surgically in adult male rats (treated group), and sham-operated rats were used as a control group. Five rats from each group were sacrificed on days 1, 3, 5, and 7 after surgery. The percentage of motile spermatozoa began to decrease 1 day after the operation, followed by an abrupt decline 3 and 5 days later in cryptorchid rats. Furthermore, there were significant decreases in the other sperm motility parameters 5 days after inducement of cryptorchidism. In cryptorchid rats, plasma concentrations of LH, FSH, testosterone, and inhibin B were significantly lower than in the control group 1 day after the operation. Thereafter, plasma concentrations of LH, FSH, and testosterone gradually increased in the cryptorchid rats. On the other hand, plasma concentrations of inhibin B showed a further decline from day 3 after the operation onward. Concentrations of immunoreactive (ir)-inhibin, but not testosterone, in testicular interstitial fluid were remarkably increased until 3 days after surgery in the cryptorchid rats, and declined thereafter. Testicular response to human chorionic gonadotropin (hCG) for testosterone release was decreased in the cryptorchid rats compared with the control rats, indicating that heat stress to testes resulted in a reduction of the activity of Leydig cells and Sertoli cells. These results clearly indicate that heat stress to the testes resulted in a significant reduction of sperm activity within 3 days, and this was followed by changes in testicular endocrine function. Key words: Cryptorchidism, Heat stress, Inhibin B, Sperm motility, Testosterone (J. Reprod. Dev. 52: [219][220][221][222][223][224][225][226][227][228] 2006) ormal testicular descent is dependent on a series of complex endocrine and mechanical interactions [1]. In most mammalian species, the testis is kept approximately 4-5 C below body temperature. This lower temperature has been shown to be important for normal germ cell development and testicular function [2,3]. A slight increase in testicular temperature for a short period results in a rapid loss of mature germ cells [4,5], and the number of primary spermatocytes and spermatids drops rapidly [6]. In the field of animal production, summer sterility is a serious problem especially in male domestic animals, such as pigs, cattle, and stallions. In the rat, testicular damage caused by cryptorchidism is reversible, if the

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“…As evidence, among primates, both exercise and aggressive interactions increase testosterone concentrations (Perachio, 1978;Elias, 1981;Sutton, Coleman, Casey, and Lazarus, 1973;Davies and Few, 1973;Dessypris, Kuoppasalmi, and Adlercreutz, 1976;Kuoppasalmi, Naveti, Rehunen, Harkonen, and Adlercreutz, 197(i), while exogenous manipulations of testosterone concentrations within the physiological range typically do not cause parallel changes in rates of aggression (D&on, 1979;Rose, 1985). Elevated levels of aggression are common during male immigration in cercopithecine primate groups (Pusey and Packer, 1986), but immigration is not always accompanied by the extreme levels of aggression described here, and immigrant males are sometimes relatively nonaggressive (Colvin, 1983;Cheney, 1983;Strum, 1982;Smuts, 1985).…”

Section: Discussionmentioning

confidence: 99%

Behavioral, endocrine, and immunological correlates of immigration by an aggressive male into a natural primate group

Alberts

Sapolsky

Altmann

1992

Hormones and Behavior

159

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A very aggressive young adult male entered one of three long-term study groups of yellow baboons, Papio cynocephalus, approximately 3 weeks after an immobilization project began. The immigrant male's rate of agonistic encounters was appreciably higher than average, and these interactions disproportionately involved adult females as targets. Basal cortisol concentrations were higher and total lymphocyte counts lower for individuals immobilized during the immigration situation than for other individuals; these effects were greater for females than for males. Among animals whose endocrine data were obtained during the immigration period, some were specific targets of the immigrant male's aggression and others were not. Lvmphocyte counts were significantly lower for those individuals who were victims of the male's aggression than for noninvolved individuals; a nonsignificant tendency toward higher basal cortisol concentrations for victims was observed as well. The immigrant male himself had a high basal cortisol concentration, a low lymphocyte count, and a testosterone concentration that was triple the average for adult males and almost double the second highest value in the population.

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Plasma cortisol, testosterone, androstenedione and luteinizing hormone (LH) in a non-competitive marathon run

Cited by 172 publications

References 30 publications

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

Effect of Short Period Vasectomy on FSH, LH, Inhibin and Testosterone Secretions, and Sperm Motility in Adult Male Rats

Effects of Experimental Cryptorchidism on Sperm Motility and Testicular Endocrinology in Adult Male Rats

Behavioral, endocrine, and immunological correlates of immigration by an aggressive male into a natural primate group

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