Plasma Concentrations of Insulin, Glucose, Free Fatty Acids and Ketone Bodies in the Foetal and Newborn Sheep and the Response to a Glucose Load Before and After Birth

Alexander, Pauline; Britton, H.G.; Cohen, Neil; Nixon, D. A.

doi:10.1159/000240183

Cited by 22 publications

(12 citation statements)

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“…These factors may help t o explain some of the earlier conflicting data regarding insulin secretion responses in several species. Reported insulin responses to glucose injections in both the monkey (1 8), rat (1 5), and man (21) were minimal, whereas, in the fetal sheep, a response t o acute glucose o r fructose injection has been observed by some authors (4,5,9) and not by others (25). The present results suggest that some of this variation may relate t o the degree and duration of the stimulus.…”

Section: Discussionmentioning

confidence: 53%

“…Immunoreactive insulin was measured load in several species are conflicting; insulin levels have been by a modification of the double antibody technique of Morgan described as either increasing in sheep (4,5,9) and man (17,and Lazarow (19). Glucagon was assayed using a double 21) or remaining unchanged in man (2), monkeys (18), and antibody radioimmunoassay developed in our laboratory (23);…”

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confidence: 99%

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Insulin-Glucagon Substrate Interrelations in the Fetal Sheep

et al. 1974

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Extract METHODS AND MATERIALSTwenty-four studies were conducted in 14 sheep fetuses to Fourteen healthy date-bred pregnant ewes with gestational investigate the pancreatic islet a! and /3 cell responses to ages ranging from 100-145 days were studied. The chronic substrate infusions. The studies were conducted between 100 indwelling catheter preparation was utilized and has been days gestation and near term, using indwelling vascular described previously (14). Briefly, a laparotomy through a left catheters for infusions and blood sampling. constant glucose flank incision was performed using spinal anesthesia and infusions (6 mg/kg/min) produced a significant rise in the aseptic technique. Either a jugular vein and carotid artery or a mean concentration of insulin in plasma by 105 min, but no femoral vein and artery were isolated and catheterized, change in glucagon in plasma was observed. Near term (>I35 depending on whether the fetal head or hind limb was most days) the mean plasma insulin increment with constant glucose conveniently exposed. Following catheter placement, the fetus infusion was significantly greater and occurred sooner than in was returned to the uterine cavity and the laparotomy closed.fetuses early in gestation (

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Section: Discussionmentioning

confidence: 53%

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confidence: 99%

Insulin-Glucagon Substrate Interrelations in the Fetal Sheep

et al. 1974

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“…However, the incremenits in glucose and insulin were small in comparison to the glucagon response. DISCUSSION The initial fall in blood gluicose with subsequent return to euglycemic levels by days 2-3, as well as the sluggishness of insulin secretion in fetal and newborn humans, primates, and other animiifals miiodels is well documented in the literature (20)(21)(22)(23)(24)(25)(26)(27)(28). Plasma glucagon concentrations in the present studies were observed to increase during the first 2 h of life in infants studied both cross-sectionally and longitudinally.…”

Section: Iximated 4% In the Mid Portion Of The Standardmentioning

confidence: 85%

Spontaneous and Amino Acid-Stimulated Glucagon Secretion in the Immediate Postnatal Period

Sperling¹,

DeLamater²,

Phelps³

et al. 1974

J. Clin. Invest.

127

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“…Insulin concentrations appear to remain low in the immediate post-natal period also [9], but in older lambs insulin concentrations and the response to glucose are similar to those of adults [7,10]. On the other hand corticosteroid concentrations in newborn lambs appear to be higher than those of older sheep [11].…”

Section: Introductionmentioning

confidence: 87%

“…Plasma insulin concentrations in foetal lambs are low [7,8,9] and may be unresponsive to changes in plasma glucose concentration [7,9]. Insulin concentrations appear to remain low in the immediate post-natal period also [9], but in older lambs insulin concentrations and the response to glucose are similar to those of adults [7,10].…”

Section: Introductionmentioning

confidence: 99%