Plasma Concentrations of Glucose, Insulin, and Percent Glycosylated Hemoglobin Are Unaltered by Food Restriction in Rhesus and Squirrel Monkeys

Cutler, Richard G.; Davis, Barbara J.; Ingram, Donald K.; Roth, George S.

doi:10.1093/geronj/47.1.b9

Cited by 33 publications

(18 citation statements)

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“…Surprisingly, CR dwarf females had higher glucose levels than AL dwarfs. These findings in CR mice may be similar to those seen in monkeys in which there were no differences in glucose and insulin during the first two years of a restricted diet (29). The mice in the present study had been restricted for only 3-6 months.…”

Section: Blood Glucose and Insulinsupporting

confidence: 86%

“…Caloric restriction has been shown to be effective in reducing plasma glucose and insulin levels and increasing insulin sensitivity in rodents (10,27,28). Reductions in glucose and insulin were evident in monkeys as well, but only after 3-4 years of diet restriction (10,29). If not merely a result of CR, low glucose and insulin may be contributing to the mechanism for delayed aging.…”

Section: Blood Glucose and Insulinmentioning

confidence: 99%

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Studies of aging in ames dwarf mice: Effects of caloric restriction

Mattison

Wright

Bronson

et al. 2000

AGE

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Ames dwarf mice, which are small and deficient in growth homone (GH), prolactin (PRL), and thyroid stimulating hormone (TSH) live much longer (1-1.25 years) than their normal siblings. It was of interest to examine the response of these animals to caloric restriction (CR) because of the possibility that dwarf mice are voluntarily caloric restricted. We are testing the hypothesis that this possible natural caloric restriction will negate any benefits of an imposed CR on lifespan. Male and female Ames dwarf mice and their normal counterparts have been fed ad libitum (AL) or a 30% CR diet for 25-29 months. Animals were monitored daily and weighed weekly. At 12-15 months of age, CR mice weighed significantly less than their AL fed counterparts (normal females: -42%, normal males: -23%, dwarf females: -18.8%, and dwarf males: -22.2%). Only in dwarf females has this significant difference disappeared with age. At one year of age, a comparison of daily food consumption revealed that female dwarf mice consume significantly more food per gram body weight than normal females and a similar tendency is evident for males. Although they received 30% less food, CR mice ate the same amount as AL mice per gram body weight. On measures of total locomotor activity, CR mice were significantly more active than their AL-fed counterparts. On an inhibitory avoidance learning task, 18-21 month old dwarf mice exhibited significantly better retention than their age-and diet-matched normal counterparts. Histopathological analysis in aging dwarf versus normal mice suggested that the incidence of tumors does not differ between the two groups but tumors appear to develop later in dwarf than in normal mice. After 2.25 years on the study 27% of AL normals, 52% of CR normals, 74% of AL dwarfs, and 87% of CR dwarfs are still alive. We conclude that Ames dwarfs are not CR mimetics although they share many characteristics. It remains to be determined whether CR will delay aging and cause a further life extension in Ames dwarf mice.

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Section: Blood Glucose and Insulinsupporting

confidence: 86%

Section: Blood Glucose and Insulinmentioning

confidence: 99%

Studies of aging in ames dwarf mice: Effects of caloric restriction

Mattison

Wright

Bronson

et al. 2000

AGE

Self Cite

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“…A reduction in fasting glucose was not evident immediately in the NIA monkeys [14], but levels (Ϯ SEM) amount of trunk fat determined by dual energy X-ray absorptiometry after 6 (females; a) or 11 (males; b) years on DR. Ages at the time data were collected for females: juvenile 7-9, adult 6-13 and old 22-27 years; for males: juvenile 12-13, adult 14-16 and old 28-34 years. The effect of DR on reducing trunk fat was significant for both genders (p Ͻ 0.05).…”

Section: Glucose Insulin and Metabolic Ratementioning

confidence: 96%

Dietary Restriction in Aging Nonhuman Primates

Mattison¹,

Roth²,

Lane³

et al. 2006

Interdisciplinary Topics in Gerontology

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Dietary restriction (DR) has been shown to benefit health and longevity in a wide variety of species, although most have maximal life spans of only a few years. In 1987, the National Institute on Aging began the first well-controlled long-term study in a species with a considerably longer life span and a closer physiology to humans. Using rhesus monkeys (Macaca mulatta), an extensive array of physiological measures have been conducted in both males and females to evaluate the effects of DR. Monkeys benefit from DR with a lower body weight, body fat, blood glucose and thus are at lower risk for developing diabetes. Changes in several endocrine measures indicate an altered hormonal axis; however, circadian patterns and timing relative to the onset of DR can obscure the differences. Despite the caloric deficit, female monkeys are not reproductively compromised, and both males and females may benefit immunologically. There remains much to be learned from this model of DR including whether long-term DR will increase life span in a primate species.

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“…Caloric restriction of dietary intake has been shown to alter significantly a wide range of biological processes and, in particular, to attenuate age-related disease in rodent models of aging (4,(8)(9)(10)(11). This dietary manipulation has been demonstrated to attenuate the development of oxygen radicalinduced cell damage, to maintain more robust host responses protecting against deleterious extrinsic and intrinsic challenges to normal cell, tissue and organ function, and to maintain general body-wide physiologic functions (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Recent studies have interpreted these macro-observations at the molecular level by identifying that caloric restriction could stop aging-associated changes in the expression of numerous genes (12,13), including altering insulin-like growth factor 1, which is associated with agerelated decreases in insulin sensitivity (20,26,27).…”

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confidence: 99%

Differential gender effects of a reduced‐calorie diet on systemic inflammatory and immune parameters in nonhuman primates

Ebersole

Steffen

Reynolds

et al. 2008

J of Periodontal Research

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Dietary manipulation, including caloric restriction, has been shown to significantly impact host response capabilities, particularly associated with aging. This investigation compared systemic inflammatory and immune response molecules in rhesus monkeys (Macaca mulatta) on continuous long term calorie-restricted (CR) diets with a matched group of animals on a control diet, examining the effects of both gender and aging. The results demonstrated that haptoglobin and α 1 antiglycoprotein were elevated in serum of male monkeys. Serum IgG antibody responses to C. rectus, A. actinomycetemcomitans, and P. gingivalis were significantly elevated in female monkeys. While only the antibody to F. nucleatum was significantly affected by the calorie-restricted diet in females, antibody levels to P. intermedia, C. rectus and T. denticola demonstrated a similar trend. In this investigation, only selected serum antibody levels were influenced by the age in male animals, seemingly related to increasing clinical disease in this gender. More generally, analytes were modulated by gender and/or diet in this oral model system of mucosal microbial challenge.

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Plasma Concentrations of Glucose, Insulin, and Percent Glycosylated Hemoglobin Are Unaltered by Food Restriction in Rhesus and Squirrel Monkeys

Cited by 33 publications

References 0 publications

Studies of aging in ames dwarf mice: Effects of caloric restriction

Studies of aging in ames dwarf mice: Effects of caloric restriction

Dietary Restriction in Aging Nonhuman Primates

Differential gender effects of a reduced‐calorie diet on systemic inflammatory and immune parameters in nonhuman primates

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