Plasma concentrations of C-reactive protein and total homocysteine in relation to the severity and risk factors for cerebrovascular disease

Youssef, Maged Y Z; Mojiminiyi, Olusegun A.; Abdella, Nabila

doi:10.1016/j.trsl.2007.02.006

Cited by 26 publications

(23 citation statements)

References 32 publications

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“…The level of hs-CRP during the subacute phase is more closely associated with the prognosis of functional disability during the 12-month follow-up than the hs-CRP level within 24 h after stroke onset. Previous studies reported that, in stroke patients, the measurement of hs-CRP within 24 h of stroke symptoms can be an independent predictor of prognosis, death, and cardiovascular mortality [7,19,20,21]. We believe that the reason for the discrepancy between the results of our study and those of the previous studies is that the previous studies were not focused on functional outcome but rather on mortality and subsequent stroke.…”

Section: Discussioncontrasting

confidence: 96%

Relationship between High-Sensitivity C-Reactive Protein and Clinical Functional Outcome after Acute Ischemic Stroke in a Korean Population

Song

Kim

et al. 2009

Cerebrovasc Dis

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Background: High-sensitivity C-reactive protein (hs-CRP) has been shown to be a powerful predictor of coronary ischemic events. However, the prognosis of functional disability in patients with cerebrovascular disease has not been well established. Therefore, we performed this study to determine the prognostic significance of hs-CRP levels in patients with functional disability after acute ischemic stroke. Methods: A total of 417 Korean patients with ischemic stroke were examined within 24 h after symptom onset. hs-CRP measurements were obtained on admission and on the seventhhospital day. The correlations between the concentration of hs-CRP and functional disability duration 12 months after stroke onset were analyzed. Results: The present study showed that hs-CRP levels on admission and on the seventh hospital day were significantly correlated with the modified Rankin Scale (mRS) score 12 months after stroke onset. These results also demonstrated that mRS scores are more closely associated with hs-CRP levels on the seventh hospital day than hs-CRP levels on admission. Conclusion: This study demonstrated that elevated hs-CRP levels on the seventh hospital day, rather than within 24 h after stroke onset, could strongly predict the prognosis of functional disability. These results supported that hs-CRP is a useful marker of ischemic stroke in the Korean population.

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Section: Discussioncontrasting

confidence: 96%

Relationship between High-Sensitivity C-Reactive Protein and Clinical Functional Outcome after Acute Ischemic Stroke in a Korean Population

Song

Kim

et al. 2009

Cerebrovasc Dis

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“…10 However, the relationship between high plasma homocysteine levels and stroke outcomes remains controversial because some studies have found an association, whereas others have not. 6,7,11 The mechanisms underlying these associations are incompletely understood; however, some hypothetical causes might lead to functional disability.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine as a Predictor of Early Neurological Deterioration in Acute Ischemic Stroke

Kwon

Lee

Bae

et al. 2014

Stroke

145

127

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We examined total homocysteine by quartiles of increasing levels to evaluate for possible threshold effects. Baseline and clinical Background and Purpose-Hyperhomocysteinemia is a well-known risk factor for vascular disease. However, its action, mechanism, and role in the acute phase of stroke have not been determined. We tried to determine whether an association existed between elevated serum homocysteine levels and early neurological deterioration (END) in patients with acute ischemic stroke. Methods-We performed a secondary analysis from the Cilostazol in Acute Ischemic Stroke Treatment (CAIST) trial, which was a double-blinded, randomized, multicenter trial, assessing the noninferiority of cilostazol over aspirin within 48 hours of an acute ischemic stroke. END was defined as an increase of ≥1 point in motor power or an increase of ≥2 points in the total National Institute of Health Stroke Scale score within 7 days. Results-The mean (±SD) serum homocysteine level was 11.4±4.7 μmol/L. Of the 396 patients studied, 57 (14.4%) patients worsened during the 7 days after inclusion. Most (68%) of the END cases occurred within the first 24 hours after treatment. High levels (>10.3 μmol/L) of serum homocysteine were independent predictors for END (third quartile odds ratio, 3.45; 95% confidence intervals, 1.25-9.50; P=0.016; fourth quartile odds ratio, 3.36; 95% confidence intervals 1.18-9.52; P=0.023) in multivariate analysis. Conclusions-Patients

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“…During the past few years, increased plasma Hcy level has been linked to an increased risk of premature coronary artery disease and ischemic stroke [15]. However, the relationship between high plasma Hcy levels and stroke outcome remains controversial, as some studies have found an association while others have not [7,16,17].…”

Section: Discussionmentioning

confidence: 99%

Are plasma homocysteine levels related to neurological severity and functional outcome after ischemic stroke in the Korean population?

Song¹,

Kim²,

Ryu³

et al. 2009

Journal of the Neurological Sciences

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Plasma concentrations of C-reactive protein and total homocysteine in relation to the severity and risk factors for cerebrovascular disease

Cited by 26 publications

References 32 publications

Relationship between High-Sensitivity C-Reactive Protein and Clinical Functional Outcome after Acute Ischemic Stroke in a Korean Population

Relationship between High-Sensitivity C-Reactive Protein and Clinical Functional Outcome after Acute Ischemic Stroke in a Korean Population

Homocysteine as a Predictor of Early Neurological Deterioration in Acute Ischemic Stroke

Are plasma homocysteine levels related to neurological severity and functional outcome after ischemic stroke in the Korean population?

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