Relationship between High-Sensitivity C-Reactive Protein and Clinical Functional Outcome after Acute Ischemic Stroke in a Korean Population

Song, In‐Uk; Kim, Joong‐Seok; Kim, Yeong-In; Lee, Kwang Soo; Jeong, Du-Shin; Chung, Sung Woo

doi:10.1159/000247597

Cited by 45 publications

(33 citation statements)

References 55 publications

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“…Elkind et al [24] detected elevated CRP levels even 28 days after ischemic stroke indicating a prolonged inflammatory response by CRP. Welsh et al [25] and Song et al [26] recently demonstrated the association of CRP levels within the first day after stroke with functional outcome.…”

Section: Discussionmentioning

confidence: 99%

The Temporal Profile of Inflammatory Markers and Mediators in Blood after Acute Ischemic Stroke Differs Depending on Stroke Outcome

et al. 2010

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Background: Early inflammation has been suggested as an important factor contributing to unfavorable prognosis after acute ischemic stroke. The present study aimed to clarify the temporal dynamics of discrete inflammatory markers/mediators for future mechanism-targeting anti-inflammatory strategies in ischemic brain damage. Methods: Blood samples of 69 patients with transient ischemic attack or ischemic stroke were taken upon admission and at time points 6, 12 and 24 h, as well as 3 and 7 days after symptom onset for analysis of monocyte chemotactic protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), interleukin-6 (IL-6), C-reactive protein (CRP) and the brain damage marker S100B. Clinical scores (modified Rankin Scale, National Institute of Health Stroke Scale) were assessed on day 90. Results: MCP-1, MMP-9, TIMP-1, IL-6, CRP and S100B showed significantly different time courses depending on stroke outcome. While the levels of IL-6, MCP-1 and MMP-9 increased already a few hours after symptom onset, CRP and S100B gradually rose commencing at 12–24 h. TIMP-1 demonstrated an extended plateau. By multiple linear regression analysis IL-6, MCP-1, TIMP-1 and S100B were determined to be independently related to clinical outcome scores at specific time points. Conclusions: Our data show important differences in the early time course of several potential markers for the complex network of inflammation and brain damage after ischemic stroke depending on stroke outcome. This must be considered for any therapeutical approach using anti-inflammatory treatment.

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Section: Discussionmentioning

confidence: 99%

The Temporal Profile of Inflammatory Markers and Mediators in Blood after Acute Ischemic Stroke Differs Depending on Stroke Outcome

et al. 2010

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“…Increased circulating levels of inflammatory biomarkers are associated with an adverse neurological outcome in patients with ischemic stroke [37,38,39], suggesting that the link between GDF-15 and inflammation may also contribute some of the prognostic information provided by GDF-15. In patients with acute coronary syndrome, similar associations between GDF-15 and inflammatory biomarkers, including IL-6 and CRP, have been observed [9,10].…”

Section: Discussionmentioning

confidence: 99%

Growth Differentiation Factor 15 Plasma Levels and Outcome after Ischemic Stroke

Worthmann¹,

Kempf²,

Widera³

et al. 2011

Cerebrovasc Dis

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Background: Growth differentiation factor 15 (GDF-15) is a stress-responsive cytokine that is induced after experimental brain injury. We hypothesized that the circulating levels of GDF-15 are increased and associated with neurological outcome in patients with ischemic stroke. Methods: Serial blood samples were obtained between 6 h and 7 days after symptom onset in 57 consecutive patients with acute ischemic stroke (n = 51) or transient ischemic attack (n = 6). GDF-15 was measured by immunoradiometric assay. Neurological outcome using the modified Rankin Scale (mRS) at 7 and 90 days was classified as favorable (mRS 0 or 1) or unfavorable (mRS >1). Results: Six hours after symptom onset, GDF-15 levels were abnormally high (>1,200 ng/l) in 68% of the patients. They declined by 8% over the course of 7 days (p < 0.001). GDF-15 levels were correlated with the circulating levels of the inflammatory marker interleukin-6 and the glial protein S100 calcium binding protein B, and with carotid intima-media thickness. Ischemic stroke patients with an mRS score >1 at 7 or 90 days had higher circulating levels of GDF-15 at all preceding sampling time points compared to patients with an mRS score of 0 or 1 (p ≤ 0.002). Similarly, in a logistic regression analysis, GDF-15 levels measured between 6 h and 7 days after symptom onset were associated with mRS at 7 and 90 days. Conclusions: These data show for the first time that the circulating levels of GDF-15 are elevated and associated with neurological outcome in patients with ischemic stroke.

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“…It is a member of the long pentraxins (2). Studies have shown that higher levels of C-reactive protein (CRP), which is a classical short pentraxin, are associated with worsening prognosis of IS (3)(4)(5). In acute infections PTX3 plays a protective role by reducing the inflammatory response (6).…”

Section: Introductionmentioning

confidence: 99%

Serum amyloid A, fetuin-A, and pentraxin-3 levels in patients with ischemic stroke: novel prognostic biomarkers?

Sezer¹,

Uçar²,

Ulusoy³

et al. 2014

Turk J Med Sci

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A nonlinear process between co-propagating signal and control pulses has been proposed and demonstrated numerically, based on semiconductor optical amplifiers (SOA). Results show that a Gaussian signal pulse with picosecond duration can be simultaneously amplified and compressed in a SOA by utilizing a co-propagating high-intensity control pulse. To obtain high quality signal pulse with high peak power level and short pulse width, the center carrier wavelengths of two pulses should locate in the gain region of the SOA. The initial delay time between both pulses should be tuned suitably before entering the SOA.

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Relationship between High-Sensitivity C-Reactive Protein and Clinical Functional Outcome after Acute Ischemic Stroke in a Korean Population

Cited by 45 publications

References 55 publications

The Temporal Profile of Inflammatory Markers and Mediators in Blood after Acute Ischemic Stroke Differs Depending on Stroke Outcome

The Temporal Profile of Inflammatory Markers and Mediators in Blood after Acute Ischemic Stroke Differs Depending on Stroke Outcome

Growth Differentiation Factor 15 Plasma Levels and Outcome after Ischemic Stroke

Serum amyloid A, fetuin-A, and pentraxin-3 levels in patients with ischemic stroke: novel prognostic biomarkers?

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