Plasma concentrations and placental immunostaining of interleukin-10 and tumornecrosis factor-α as predictors of alterations in the embryo-fetal organism and the placental development of diabetic rats

Sinzato, Yuri Karen; Damasceno, Débora Cristina; Laufer-Amorim, Renée; Rodrigues, Marcela Marcondes Pinto; Oshiiwa, Marie; Taylor, Keith; Rudge, Marilza Vieira Cunha

doi:10.1590/s0100-879x2011007500015

Cited by 13 publications

(15 citation statements)

References 20 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Increased plasma levels of TNF-α have been reported by other groups in experimental diabetes in mice and rats (Lukic et al 1998; Jain et al 2007) and in human type 1 diabetics (Padgett et al 2013). Plasma IL-10 levels has been reported to fall in STZ rats (Sinzato et al 2011) but an increase in plasma IL-6 (Jain et al 2007) or IFN-γ levels (Lukic et al 1998) reported previously in STZ-treated rats were not measured in the present study. Although plasma cytokine values may be important because they translate to human studies, there are relatively few studies and results may vary according to the animal model used.…”

Section: Discussioncontrasting

confidence: 69%

Indomethacin reverses decreased hippocampal cell proliferation in streptozotocin-induced diabetic mice

Brookshire

Clark

et al. 2014

Metab Brain Dis

View full text Add to dashboard Cite

Diabetes in humans and animals is accompanied by chronic low-grade inflammation, which could be a possible mediator of developing neuropathology and neurobehavioral deficits. The objective of the present study determined if decreasing inflammation could reverse diabetes-induced decreases in hippocampal cell proliferation, one aspect of hippocampal neurogenesis. C57BL/6J mice were made diabetic by administering streptozotocin (STZ; 195 mg/kg). STZ mice or vehicle controls received chronic treatment with the non-steroidal anti-inflammatory drug indomethacin (2 mg/kg for 14 days). Levels of glucose, corticosterone and, cytokines were measured from plasma, cell proliferation was measured using BrdU incorporation in the hippocampus and TNF-αR1 and TNF-αR2 mRNA was measured using real-time PCR. STZ-induced diabetes increased plasma levels of glucose and corticosterone and decreased body weight. Cell proliferation in the hippocampus was reduced in diabetic mice by 50%. The decreased level of cell proliferation was reversed by chronic treatment with indomethacin without changes to corticosterone and glucose levels. Plasma TNF-α levels increased in diabetic mice and were normalized by indomethacin treatment and IL-1 and IL-6 levels were unchanged by diabetes or indomethacin. In contrast, plasma levels of the cytokines IL-10 and IFN-gamma decreased in diabetic mice and were not affected by indomethacin treatment. STZ-induced diabetes decreased expression of TNF-αR2 but not TNF-αR1 mRNA. Indomethacin ameliorated the effects of STZ on hippocampal neurogenesis independent of corticosterone and glycemic control, possibly by mediating the proinflammatory cytokine TNF-α. Inflammation is a potential novel pharmacological target for alleviating neurobehavioral complications arising from diabetes.

show abstract

Section: Discussioncontrasting

confidence: 69%

Indomethacin reverses decreased hippocampal cell proliferation in streptozotocin-induced diabetic mice

Brookshire

Clark

et al. 2014

Metab Brain Dis

View full text Add to dashboard Cite

show abstract

“…This alteration would explain the implantation loss observed in our previous experiments (Barão et al, 2008b;Dorce et al, 2014). Moreover, our results agree with Sinzato et al (2011), who observed that diabetic rats had decreased IL-10 and an increase in pre-and post-implantation losses. Given their crucial role in the brain development, it is not surprising that elevated levels of proinflammatory cytokines generated by the maternal or fetal immune system have been associated with abnormal fetal brain development and increased risk for neurodevelopmental disorders and are responsible for many apparently unexplained behavioral effects occurring in adulthood (Meyer et al, 2009).…”

supporting

confidence: 92%

Tityus bahiensis scorpion venom injected to dams during pregnancy affects some cytokines of fetuses

Dorce

Frare

Paulo

et al. 2015

Toxicon

View full text Add to dashboard Cite

“…This method was first demonstrated in 1974 by Portha et al to the neonatal rats by applying 100 mg/kg STZ (62). Dağıstanlı et al (63) have used STZ in the 100 mg/kg concentration through i.p while Sinzato et al (64) have used STZ in the same concentration, but through sc This method has been the mostly preferred chemical diabetes mellitus model to create type II diabetes because it offers operational ease. Similarly, it is considered to be the best model to reflect type II diabetes mellitus clinic among the other models (40) .…”

Section: Animal Models Of Diabetes Mellitusmentioning

confidence: 99%

New Insight Into Metformin Action: Diabetes, Prostate Cancer, Ion Channels

Karabulut-Bulan¹

2016

Marmara Pharm J

View full text Add to dashboard Cite

Diabetes Mellitus is a life-long chronic metabolic disease, requiring continuous follow-up and therapy, it reduces the quality of life of patients with acute and chronic complications, mortality, and its economic burden is high. Cancer is the second cause of death, according to the data from World Health Organization. Prostate cancer is one of the most common cancers in the developed world and the second leading cause of male cancer-related death. As with the other cancer types, metastasis is an essential problem that we are facing and it is not clear whether a tumor will metastasize or not in localized state. It has been reported that there are high levels of voltage-gated sodium channels in metastatic prostate cancer cases. Cancer, ever growing with diabetes, is a major health problem. Studies have shown that diabetic patients have higher cancer rates than those of non-diabetics. Metformin is the drug of choice for the treatment of diabetes. Recently, there are studies in the literature regarding metformin reducing the risk of cancer besides its effect on diabetes This review will explain the possible role of the metformın on the three dimensional relationship of prostate cancer, diabetes and ion channels, and provide a significant contribution to clinical trials.

show abstract

Plasma concentrations and placental immunostaining of interleukin-10 and tumornecrosis factor-α as predictors of alterations in the embryo-fetal organism and the placental development of diabetic rats

Cited by 13 publications

References 20 publications

Indomethacin reverses decreased hippocampal cell proliferation in streptozotocin-induced diabetic mice

Indomethacin reverses decreased hippocampal cell proliferation in streptozotocin-induced diabetic mice

Tityus bahiensis scorpion venom injected to dams during pregnancy affects some cytokines of fetuses

New Insight Into Metformin Action: Diabetes, Prostate Cancer, Ion Channels

Contact Info

Product

Resources

About