Plasma Concentrations and Cardiovascular Influence of Lidocaine Infusions During Isoflurane Anesthesia in Healthy Dogs and Dogs With Subaortic Stenosis

Moraes, Aury Nunes de; Dyson, Doris H.; O'Grady, Michael R.; McDonell, Wayne N.; Holmberg, David L.

doi:10.1111/j.1532-950x.1998.tb00161.x

Cited by 35 publications

(16 citation statements)

References 20 publications

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“…Nunes de Moraes et al . [23] reported there were not any detrimental cardiovascular effects related to an infusion of lidocaine at 7.2 mg/kg/hr during isoflurane anesthesia in healthy dogs or dogs with aortic stenosis. Matsubara et al [20] reported that lidocaine infusions (3 and 12 mg/kg/hr CRI following 2 mg/kg IV) did not induce clinically significant changes in heart rate and arterial blood pressure in dogs anesthetized with sevoflurane.…”

Section: Discussionmentioning

confidence: 99%

Effects of Lidocaine, Dexmedetomidine or Their Combination on the Minimum Alveolar Concentration of Sevoflurane in Dogs

Moran-Muñoz

Ibancovichi-Camarillo

Gutiérrez‐Blanco

et al. 2014

The Journal of Veterinary Medical Science

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The aim of this study was to determine the effects of lidocaine (LIDO) and dexmedetomidine (DEX) or their combination (LIDO–DEX), administered by constant-rate infusion (CRI), on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Seven healthy mongrel dogs were used with a 2-week washout interval between treatments in this study. Anesthesia was induced with propofol and maintained with sevoflurane in oxygen, and MAC of sevoflurane was determined after 90 min equilibration period in the dogs (SEV-MACBASAL). Then, sevoflurane MAC was determined again in the dogs after 45 min equilibration period of one of the following treatments: an intravenous loading dose of lidocaine 2 mg/kg followed by 6 mg/kg/hr CRI (SEV-MACLIDO); an intravenous loading dose of dexmedetomidine 2 µg/kg followed by 2 µg/kg/hr CRI (SEV-MACDEX); or their combination (SEV-MACLIDO-DEX). These SEV-MACs were determined in duplicate. Data were analyzed using ANOVA and post hoc Tuckey test when appropriate. The SEV-MACBASAL was 1.82 ± 0.06%, SEV-MACLIDO was 1.38 ± 0.08%, SEV-MACDEX was 1.22 ± 0.10%, and SEV-MACLIDO-DEX was 0.78 ± 0.06%. The CRI administration of lidocaine, dexmedetomidine and their combination produced a significant reduction in the MAC of sevoflurane by 26.1 ± 9.0% (P<0.0001), 43.7 ± 11.8% (P<0.0002) and 54.4 ± 9.8% (P<0.0001), respectively. The MAC reduction was significantly greater after the CRI combination of lidocaine and dexmedetomidine when compared with lidocaine CRI (P<0.0001) or dexmedetomidine CRI treatments (P<0.025).

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Section: Discussionmentioning

confidence: 99%

Effects of Lidocaine, Dexmedetomidine or Their Combination on the Minimum Alveolar Concentration of Sevoflurane in Dogs

Moran-Muñoz

Ibancovichi-Camarillo

Gutiérrez‐Blanco

et al. 2014

The Journal of Veterinary Medical Science

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“…In humans, lidocaine plasma concentrations greater than 15 µg mL −1 cause bradycardia, vasodilation, and negative inotropy (Stoelting 1991). In one study of lidocaine toxicity in dogs, plasma concentrations of 2.7–5.27 µg mL −1 did not change arterial blood pressure, cardiac index, systemic vascular resistance, or electrical rhythm (DeMoraes et al. 1998).…”

Section: Discussionmentioning

confidence: 99%

Systemic lidocaine infusion as an analgesic for intraocular surgery in dogs: a pilot study

Smith

Bentley

Shih

et al. 2004

Veterinary Anaesthesia and Analgesia

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“…Lidocaine’s ability to reduce halothane, isoflurane and enflurane MAC has been reported in humans, horses, dogs and cats (Himes et al. 1977, 1979; Doherty & Frazier 1998; Moraes et al. 1998; Muir et al.…”

Section: Introductionmentioning

confidence: 98%

Effect of lidocaine on the minimum alveolar concentration of sevoflurane in dogs

Matsubara¹,

Oliva²,

Gabas³

et al. 2009

Veterinary Anaesthesia and Analgesia

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Plasma Concentrations and Cardiovascular Influence of Lidocaine Infusions During Isoflurane Anesthesia in Healthy Dogs and Dogs With Subaortic Stenosis

Abstract: Methods shown in the study can be used in clinical cases to achieve therapeutic lidocaine levels without significant cardiovascular depression during isoflurane anesthesia.

Cited by 35 publications

References 20 publications

Effects of Lidocaine, Dexmedetomidine or Their Combination on the Minimum Alveolar Concentration of Sevoflurane in Dogs

Effects of Lidocaine, Dexmedetomidine or Their Combination on the Minimum Alveolar Concentration of Sevoflurane in Dogs

Systemic lidocaine infusion as an analgesic for intraocular surgery in dogs: a pilot study

Effect of lidocaine on the minimum alveolar concentration of sevoflurane in dogs

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