“…Brannstrorn and Garberoglio (1980) found that peritubular dentin formed in extracted teeth with exposed dentin worn intraorally on a denture. They concluded that the oral milieu and saliva may contribute to peritubular dentin formation, Under carious dentin, the odontoblast and its process contain immunoglobulins (Okamura et al, 1979). This clearly suggests the involvement of the process in the response to the lesion and perhaps indicates the mechanism by which the response may be initiated.…”