Plasma Circular RNAs, Hsa_circRNA_025016, Predict Postoperative Atrial Fibrillation After Isolated Off‐Pump Coronary Artery Bypass Grafting

Zhang, Jian; Xu, Yiquan; Shu, Xu; Liu, Yu; Yu, Liming; Li, Zhi; Xue, Xiaodong; Wang, Huishan

doi:10.1161/jaha.117.006642

Cited by 31 publications

(24 citation statements)

References 18 publications

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“…11 CircRNA hsa_circ_025016 is upregulated in postoperative arterial fibrillation (PoAF) patients compared to no PoAF patients. 12 These collective evidences suggest that circRNAs might serve as biomarkers for predicting cardiovascular disease risk. CircRNA HECTD1 is highly abundant in brain, heart, and liver.…”

Section: Discussionmentioning

confidence: 99%

The role of circular RNA HECTD1 expression in disease risk, disease severity, inflammation, and recurrence of acute ischemic stroke

Peng

Jing

Chen

et al. 2019

Clinical Laboratory Analysis

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Background This study aimed to explore the correlation of circular RNA HECT domain E3 ubiquitin protein ligase 1 (circRNA HECTD1) expression with disease risk, disease severity, inflammation, and recurrence of acute ischemic stroke (AIS). Methods A total of 160 initial AIS patients and 160 controls were enrolled in this study. Peripheral blood mononuclear cells of AIS patients and controls were separated from blood samples to detect circRNA HECTD1 expression by RT‐qPCR. Inflammatory cytokines in serum of AIS patients were measured by ELISA. Furthermore, the National Institutes of Health Stroke Scale (NIHSS) score was used to evaluate disease severity of AIS patients. Additionally, disease recurrence was documented during follow‐up, and recurrence‐free survival (RFS) was calculated. Results CircRNA HECTD1 expression was higher in AIS patients than that in controls, and the receiver operating characteristic (ROC) curve revealed that circRNA HECTD1 expression was of a good value in distinguishing AIS patients from controls with area under the curve (AUC) of 0.814 (95% CI: 0.768‐0.859). In AIS patients, circRNA HECTD1 expression was positively correlated with NIHSS score, CRP, and pro‐inflammatory cytokines. CircRNA HECTD1 expression was increased in AIS recurrence patients compared to non‐recurrence patients, and further, ROC curve analysis disclosed that circRNA HECTD1 expression predicted higher risk of AIS recurrence (AUC: 0.694, 95% CI: 0.586‐0.801). Additionally, circRNA HECTD1 expression was negatively correlated with RFS. Conclusions CircRNA HECTD1 expression correlates with higher disease risk, disease severity, inflammation, and recurrence of AIS.

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Section: Discussionmentioning

confidence: 99%

The role of circular RNA HECTD1 expression in disease risk, disease severity, inflammation, and recurrence of acute ischemic stroke

Peng

Jing

Chen

et al. 2019

Clinical Laboratory Analysis

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“…Expression of circMCTP2 was only detected in human GC tissues. Circulating circRNAs are reportedly better biomarkers for certain pathologies [40,41]. In this study, plasma samples of the patients with GC were not collected, and thus we failed to analyze whether plasma circMCTP2 could be a suitable biomarker to distinguish CDDP-resistant GC patients from CDDP-sensitive patients.…”

Section: Discussionmentioning

confidence: 92%

Circular RNA MCTP2 Inhibits Cisplatin Resistance in Gastric Cancer by miR-99a-5p-Mediated Induction of MTMR3 Expression

Sun

et al. 2020

Preprint

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Background: Cisplatin (CDDP) is the first-line chemotherapy for gastric cancer (GC). Poor prognosis of GC patients is partially due to development of CDDP resistance. Circular RNAs (circRNAs) are a subclass of non-coding RNAs that function as microRNA (miRNA) sponges. The role of circRNAs in CDDP resistance in GC has not been evaluated. Methods: RNA-sequencing was used to identify the differentially expressed circRNAs between the CDDP-resistant and CDDP-sensitive GC cells. qRT-PCR was used to detect the expression of circMCTP2 in GC tissues. The effects of circMCTP2 on CDDP resistance were investigated in vitro and in vivo. Pull-down assays and Luciferase reporter assays were performed to confirm the interaction among circMCTP2, miR-99a-5p, and myotubularin related protein 3 (MTMR3). The protein expression levels of MTMR3 were detected by western blotting. Autophagy was evaluated by confocal microscopy and transmission electron microscopy (TEM).Results: CircMCTP2 was found to be downregulated in the CDDP-resistant GC cells and tissues as compared to that of the CDDP-sensitive ones. A high level of circMCTP2 was found to be a favorable factor for the prognosis of patients with GC. CircMCTP2 inhibited cell proliferation and autophagy while promoting apoptosis of CDDP-resistant GC cells in response to CDDP treatment. CircMCTP2 upregulated MTMR3 by sponging miR-99a-5p, and knockdown of MTMR3 could reverse the effects of circMCTP2 on CDDP resistance and autophagy of GC cells. Conclusions: CircMCTP2 sensitizes GC to CDDP through the upregulation of MTMR3 by sponging miR-99a-5p. Overexpression of CircMCTP2 could be a new therapeutic strategy for counteracting CDDP resistance in GC.

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“…Hsa_circ_025016 was upregulated in the plasma of patients with new-onset AF after isolated off-pump CABG. ROC analysis revealed a high diagnostic value ( Zhang J. et al, 2018 ). The analysis with a large validation cohort confirmed the diagnostic power of hsa_circ_025016 ( Zhang J. et al, 2018 ).…”

Section: Circrnas As Biomarkers For Cvdmentioning

confidence: 99%

Circular RNAs: Functions and Clinical Significance in Cardiovascular Disease

Zhang

Wang

et al. 2020

Front. Cell Dev. Biol.

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Cardiovascular disease (CVD) causes high morbidity and mortality worldwide. Accumulating research has indicated the possible roles played by circular RNAs (circRNAs) in the pathogenesis of CVD. CircRNAs are non-coding RNAs with covalently closed loop structures. CircRNAs can function by acting as miRNA sponges, RNA binding protein sponges, mRNA transcriptional regulators and templates for protein translation. The specific characteristics of circRNAs such as high stability, abundant distribution, and tissue- and developmental stage-specific expression make them potential biomarkers for the diagnosis and prognosis of CVD. In this paper, we systematically summarized the current knowledge regarding the biogenesis, biological properties and the action mechanisms of circRNAs, elucidated the roles played by circRNAs in the pathogenesis of CVD, and explored the diagnostic potential of circRNAs in CVD. With in-depth studies, an increasing number of molecular mechanisms underlying the participation of circRNAs in CVD may be elucidated, and the application of circRNAs in the clinical diagnosis and prevention of CVD may eventually be realized.

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Plasma Circular RNAs, Hsa_circRNA_025016, Predict Postoperative Atrial Fibrillation After Isolated Off‐Pump Coronary Artery Bypass Grafting

Cited by 31 publications

References 18 publications

The role of circular RNA HECTD1 expression in disease risk, disease severity, inflammation, and recurrence of acute ischemic stroke

The role of circular RNA HECTD1 expression in disease risk, disease severity, inflammation, and recurrence of acute ischemic stroke

Circular RNA MCTP2 Inhibits Cisplatin Resistance in Gastric Cancer by miR-99a-5p-Mediated Induction of MTMR3 Expression

Circular RNAs: Functions and Clinical Significance in Cardiovascular Disease

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