Plasma cell myeloma with unusual morphology–<scp>A</scp> series of 6 cases

Hussain, Naushad; Rahman, Khaliqur; Nityanand, Soniya

doi:10.1111/ejh.12310

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…As a rule, the tumor cells are larger than their nonneoplastic counterparts; however, normal and small cell sized variants have been described. Other variations include nuclear convolutions and Burkitt-like or blastic morphology [ 2 ]. Occasionally, intracellular immunoglobulin (Ig) accumulations are seen within variable sized vacuoles.…”

Section: Introductionmentioning

confidence: 99%

Multiple Myeloma with Foamy Mott Cells

Nalbandyan

Benharroch

Samueli

et al. 2021

Case Reports in Hematology

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Intracytoplasmic assorted vacuoles containing immunoglobulin collections are occasionally seen in multiple myeloma. When abundant, they impart a foamy appearance to the tumor cells, which is a potential source for diagnostic pitfalls. Herein, we report the case of a patient who presented with skeletal pain and CT confirmed lytic lesions. A bone marrow biopsy revealed multiple myeloma with unusual foamy Mott cells. The patient was subsequently treated with four cycles of cyclophosphamide, bortezomib, and dexamethasone induction therapy, followed by 3 cycles of lenalidomide with dexamethasone. A biopsy performed following initial biological and immunomodulatory drugs revealed different morphological and clonal characteristics. These features were modified again, five years later, and again, after two years of close monitoring. Hematopathologists should be aware of this morphologic variant of myeloma as well as for the capacity of clonal characteristics, such as light chain monotype, to fluctuate subsequent to treatment.

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Section: Introductionmentioning

confidence: 99%

Multiple Myeloma with Foamy Mott Cells

Nalbandyan

Benharroch

Samueli

et al. 2021

Case Reports in Hematology

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“…The most common morphological variants of plasma cell myeloma show a plasmacytic, plasmablastic or pleomorphic appearance. However, there are reports of unusual morphological variants, which do not reveal a plasmacytic morphology [2][3][4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Liver involvement by plasma cell myeloma mimicking clear cell carcinoma, a potential pitfall.

Vagena

Sill

Beham‐Schmid

2020

Preprint

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Background: Unusual morphological variants of plasma cell myeloma are a diagnostic challenge.Case presentation: A 60 year old woman with low-back pain was diagnosed with a plasma cell myeloma in the bone marrow. Concurrently a tumour was found in the liver. The histological specimen of the liver resembled a clear cell carcinoma, but the immunophenotype revealed plasma cell myeloma.Conclusion: In tumours with an extraordinary morphology and not conclusive immunohistochemical results the use of plasma cell antibodies may lead to the correct diagnosis.

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“…In minority of cases, cytological variations such as polymorphous variant (cleaved, multilobated, and monocytoid cells), blastic variant, small cells variants, anaplastic variant, signet-ring cells variant, histiocytoid cells variants, clear cells variant, spindle cells variants, oncocytic type, Burkitt-like morphology, and mimicking erythrophagocytosis are illustrated in literature. [12345] The other rare cytological variation in PCN is PC satellitism, clustering/rosette formation around macrophages. [67] These atypical morphological variants are extremely difficult for interpretation by pathologists, especially when they are accompanied by unusual clinical presentations and when BM study being done for remission status during the course of chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Plasma cell neoplasm with varied morphology: A report of two cases

Vasnik¹,

Somasundaram

Sharma

et al. 2019

J Lab Physicians

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Plasma cell (PC) neoplasm (PCN) with varied morphology has been described in the literature. The majority of clonal proliferation of PCs is composed of easily recognizable morphology in the bone marrow (BM). However, few cases may cause diagnostic complexity, as they exhibit varied cytological and architectural heterogeneity which may pose problem in morphological diagnosis and require the use of ancillary techniques like immunohistochemistry (IHC). We illustrate here two such cases of PCN with varied morphology in BM aspirate, in the form of clustering/rosetting and multiple clear cytoplasmic vacuoles, respectively, leading to varied differential diagnosis. However, later, the histopathological features on BM biopsy findings were relatively characteristic and IHC confirmed the final diagnosis. The morphological variants documented in both these cases are exceptional and representative of the various forms of atypical PCs.

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Plasma cell myeloma with unusual morphology–A series of 6 cases

Cited by 7 publications

References 11 publications

Multiple Myeloma with Foamy Mott Cells

Multiple Myeloma with Foamy Mott Cells

Liver involvement by plasma cell myeloma mimicking clear cell carcinoma, a potential pitfall.

Plasma cell neoplasm with varied morphology: A report of two cases

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