Plasma CCN2 (connective tissue growth factor; CTGF) is a potential biomarker in idiopathic pulmonary fibrosis (IPF)

Kono, Masato; Nakamura, Yutaro; Suda, Takafumi; Kato, Masato; Kaida, Yusuke; Dai, Huaping; Inui, Naoki; Hamada, Etsuko; Miyazaki, Osamu; Kurashita, Syunsuke; Fukamachi, Isamu; Endo, Kentaro; Ng, Poh-Sing; Takehara, Kazuhiko; Nakamura, Hirotoshi; Maekawa, Masato; Chida, Kingo

doi:10.1016/j.cca.2011.08.008

Cited by 70 publications

(45 citation statements)

References 35 publications

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“…Plasma levels of CCN2 were reported to be significantly higher in patients with IPF than in patients with non-IPF IIPs and healthy controls (33). That study also reported a correlation between plasma CCN2 and changes in the 6-month forced vital capacity (FVC).…”

Section: Connective Tissue Growth Factor (Ccn2)supporting

confidence: 60%

Advances in the study of biomarkers of idiopathic pulmonary fibrosis in Japan

2013

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Section: Connective Tissue Growth Factor (Ccn2)supporting

confidence: 60%

Advances in the study of biomarkers of idiopathic pulmonary fibrosis in Japan

2013

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“…Evidence has been introduced and suggested that overexpression of CTGF has been noted in numerous fibrotic disorders, including pulmonary,12 renal,13 hepatic,14 skin15 and cardiac fibrosis 11 16. In our previous study, we first demonstrated a significant upregulation of mRNA and protein expression levels of CTGF in the GO orbital fibroblasts as compared with those of normal controls 17.…”

mentioning

confidence: 75%

Expression and clinical significance of connective tissue growth factor (CTGF) in Graves' ophthalmopathy

Huang

Chang

et al. 2016

Br J Ophthalmol

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“…CTGF is a matricellular protein involved in the regulation of cell survival, proliferation, adhesion, migration, and ECM production (13). Interestingly, TGF-␤ is able to induce Ctgf expression in diverse cell types, predominantly in fibrotic disorders (14)(15)(16)(17), and Ctgf contains a TGF-␤ response element in its promoter (18). At the protein level, CTGF possesses four domains that interact with growth factors, ECM proteins, low-density lipoprotein (LDL)-receptor related proteins (LRP), and integrins (13,(19)(20)(21).…”

mentioning

confidence: 99%

CTGF Mediates Smad-Dependent Transforming Growth Factor β Signaling To Regulate Mesenchymal Cell Proliferation during Palate Development

Parada

Iwata

et al. 2013

Molecular and Cellular Biology

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Transforming growth factor ␤ (TGF-␤) signaling plays crucial functions in the regulation of craniofacial development, including palatogenesis. Here, we have identified connective tissue growth factor (Ctgf) as a downstream target of the TGF-␤ signaling pathway in palatogenesis. The pattern of Ctgf expression in wild-type embryos suggests that it may be involved in key processes during palate development. We found that Ctgf expression is downregulated in both Wnt1-Cre; Tgfbr2 fl/fl and Osr2-Cre; Smad4 fl/fl palates. In Tgfbr2 mutant embryos, downregulation of Ctgf expression is associated with p38 mitogen-activated protein kinase (MAPK) overactivation, whereas loss of function of Smad4 itself leads to downregulation of Ctgf expression. We also found that CTGF regulates its own expression via TGF-␤ signaling. Osr2-Cre; Smad4 fl/fl mice exhibit a defect in cell proliferation similar to that of Tgfbr2 mutant mice, as well as cleft palate. We detected no alteration in bone morphogenetic protein (BMP) downstream targets in Smad4 mutant palates, suggesting that the reduction in cell proliferation is due to defective transduction of TGF-␤ signaling via decreased Ctgf expression. Significantly, an exogenous source of CTGF was able to rescue the cell proliferation defect in both Tgfbr2 and Smad4 mutant palates. Collectively, our data suggest that CTGF regulates proliferation as a mediator of the canonical pathway of TGF-␤ signaling during palatogenesis.

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Plasma CCN2 (connective tissue growth factor; CTGF) is a potential biomarker in idiopathic pulmonary fibrosis (IPF)

Cited by 70 publications

References 35 publications

Advances in the study of biomarkers of idiopathic pulmonary fibrosis in Japan

Advances in the study of biomarkers of idiopathic pulmonary fibrosis in Japan

Expression and clinical significance of connective tissue growth factor (CTGF) in Graves' ophthalmopathy

CTGF Mediates Smad-Dependent Transforming Growth Factor β Signaling To Regulate Mesenchymal Cell Proliferation during Palate Development

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