Plasma catecholamines in arterial and capillary blood

Baumgartner, Holger; Wiedermann, C J; Hörtnagl, Helmut; Mühlberger, V.

doi:10.1007/bf00692916

Cited by 21 publications

(10 citation statements)

References 12 publications

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“…1, Table 1) in newborns. This agrees with recent findings in adults, where we could show that capillary blood from hyperemic earlobe and nonhyperemic fingertip resembles arterial blood in its CAT content (20). Moreover, significant correlations exist between arterial as well as capillary CAT and heart rate, Pco?, pH, weight, and gestational and postpartal age; thus, capillary A and NA can be used as a substitute for arterial CAT in newborns.…”

Section: Discussionsupporting

confidence: 93%

“…Analysis. Catecholamines in arterial, capillary, and control plasma samples were determined by a previously described (20) radioenzymatic method with the following modifications: only 25 pL of deproteinized plasma were used; 5 pCi S-adenosylmethionine-3H of a high radioactive concentration were added in 5 pL of volume [Amersham TRK 865 (Amersham Int. plc, Buckinghamshire, UK); 1 mCi/mL].…”

Section: Abbreviationsmentioning

confidence: 99%

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Capillary Versus Arterial Plasma Catecholamines as Markers for Sympatho-Adrenal Activity in Infants

et al. 1992

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ABSTRACT. In this study, we investigated whether cap-procedures can have ethical and practical limitations, particularly illary plasma catecholamines can be used as a suitable in healthy infants. The aim of this study was to investigate substitute for arterial catecholamines. Analysis was done whether the use of capillary plasma CAT can be an alternative. radioenzymatically. Catecholamine concentrations were not different in arterial and simultaneously collected "ar- Group 1. For comparison of "arterialized" capillary with arteHowever, "arterialization" of capillary blood is important; rial CAT concentrations, two blood samples were taken simulwhen blood was obtained in nine neonates without warming taneously by heel prick from the hyperemic (warmed) foot and their feet, capillary concentrations of noradrenaline were from an indwelling umbilical arterial catheter in 18 infants (five higher than arterial values (p < 0.03) and those of adren-girls, 13 boys) between d 1 and 14 (mean 5.5 d) after birth aline were not different from arterial values. Catecholamine (average gestational age, 35 wk). Their birth weights ranged from concentrations in arterialized capillary plasma collected in 1240 to 4230 g (mean, 2423 g); five were full-term and 13 were healthy full-term infants at 1 h [n = 9; noradrenaline: 6.85 preterm babies. well-known fall ( p < 0.01) in catecholamine levels after from an indwelling umbilical arterial catheter in nine infants delivery. With a highly sensitive analytical technique, cate-(four girls, five boys) between d 1 and 13 (mean 3.3 d) after birth cholamine concentrations can reliably be assessed in mi-(average gestational age, 35 wk); their birth weights ranged from nute samples (100-200 pL) of arterialized capillary blood, 980 to 4730 g (mean, 238 1 g); three were full-term and six were even when concentrations have dropped to low "resting" preterm babies. basal levels. Moreover, the capillary sampling procedure Healthy neonates. Arterialized capillary blood (warmed foot) is simple and safe, can easily be applied to healthy infants, was obtained by heel prick from two groups of apparently and does not have the practical and ethical limitations of healthy, full-term infants, when capillary puncture was done for arterial blood sampling. (Pediatr Res 31: 579-582, 1992) routine medical purposes. All 27 newborns had uneventful neonatal periods; birth weights were 3334 + 294 g (mean +. SD). AbbreviationsTwo groups were studied. Group 3. Eighteen infants (nine girls, nine boys) were studied CAT, catecholamine on approximately their 5th d of life. A, adrenaline Group 4. Nine infants (two girls, seven boys) born during the NA, noradrenaline daytime by uncomplicated deliveries (five vaginally and four by cesarean section) with Apgar scores of 10 at 10 min were studied at 1 h after birth and approximately d 5 (4-6) after birth. The study protocols had been approved by the ethical comPlasma CAT are successfully used to study the stressful peri-mittee of the medical faculty and parental consent was obtain...

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Section: Discussionsupporting

confidence: 93%

Section: Abbreviationsmentioning

confidence: 99%

Capillary Versus Arterial Plasma Catecholamines as Markers for Sympatho-Adrenal Activity in Infants

et al. 1992

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“…Epinephrine is secreted from the adrenal gland, and the arterial concentration is higher than venous. 15 Resting plasma epinephrine concentration tends to decrease throughout life, whereas resting plasma norepinephrine increases significantly with age. 16 The main source of plasma norepinephrine is spillover from sympathetic nerve terminals.…”

Section: Discussionmentioning

confidence: 99%

“…The lower epinephrine concentration at follow-up was most likely attributable to venous instead of arterial sampling. 15 In addition, aging may also reduce epinephrine levels. 16 The increase in norepinephrine concentration at follow-up was substantial and is consistent with the gradual increase in norepinephrine concentrations observed during aging.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Stability of Cardiovascular and Catecholamine Responses to Stress Tests

et al. 2010

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Abstract-Cardiovascular (CV) hyperreactivity to stress must be reasonably stable if it is considered to be important in the development of hypertension and CV disease. The aim of the present study was to assess long-term stability of blood pressure, heart rate, epinephrine, and norepinephrine responses to a cold pressor test and a mental arithmetic stress test. Eighty-one subjects selected from the first (nϭ30), 50th (nϭ30), and 95th to 99th (nϭ39) percentiles of the mean blood pressure distribution at a military draft procedure were tested on 2 occasions 18 years apart. Stress responses were measured during a cold pressor test (hand immersed in ice water for 1 minute) and during a mental stress test (subtraction for 5 minutes). Intra-arterial blood pressure measurements and arterial catecholamine samples were taken at the initial examination. At follow-up, noninvasive Finapres beat-to-beat blood pressure measurements and venous plasma catecholamine samples were used. The 18-year correlations of the CV and epinephrine absolute responses during mental stress ranged from 0.6 to 0.8. The entry/follow-up correlation of systolic blood pressure during the mental stress test (95% CI: 0.69 to 0.86) was significantly higher than during the cold pressor test (95% CI: 0.30 to 0.65), and responses to mental stress overall appeared to be more stable than responses to the cold pressor test. Our study suggests that CV and sympathoadrenal reactivity, specifically to mental stress, are relatively stable individual characteristics. These results support one of the necessary preconditions to consider hyperreactivity involved in the development of hypertension and CV disease. Key Words: physiological stress reactivity Ⅲ stability Ⅲ cold pressor test Ⅲ mental stress Ⅲ epinephrine Ⅲ norepinephrine Ⅲ blood pressure T he reactivity hypothesis suggests that subjects with an exaggerated response to stress are at risk of later developing hypertension and cardiovascular (CV) disease. 1 The validity and the importance of the hypothesis have been discussed extensively for some decades. 2 According to Treiber et al, 3 there is reasonable evidence to suggest that CV reactivity can predict the development of some preclinical states, that is, hypertension and left ventricular hypertrophy. To consider hyperreactivity as a contributing factor in the development of CV diseases, an important precondition needs to be addressed; the reactivity of an individual must show a reasonable stability in the long term. 4 A meta-analysis from 1996 summarizing important testretest studies assessing reactivity found mean Pearson correlation r values of heart rate to equal 0.56, whereas it was 0.41 for systolic and 0.35 for diastolic blood pressures (BPs). 5 Most of the studies included were on the basis of test-retest intervals of days to months, and there were few studies with intervals of more than a year. They concluded that the reproducibility of systolic BP and heart rate declined as the test-retest interval increased, questioning the importance of hyperreac...

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“…It has been known for many years that cir culating catecholamines are removed by up take and metabolism [Vane, 1969] and that on the whole there is more adrenaline in arterial than in venous blood, while with noradrenaline the difference may be re versed [Callingham and Barrand, 1979;Baumgartner et al" 1985], The blood may be an important compartment into which nor adrenaline overflows when it escapes the lo cal uptake processes in the vicinity of the nerve varicosity. Moreover, the blood is by far the major route by which catecholamines released from the adrenal medulla or admin istered parenterally are transported to tis sues in which they are inactivated.…”

Section: The Fate Of Circulating Catecholaminesmentioning

confidence: 99%

Some Aspects of the Enzymic Inactivation of Sympathomimetic Amines

Callingham¹

1987

J Vasc Res

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This review seeks to discuss the possible importance of monoamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) in terminating the effects of released sympathetic transmitters and in the inactivation of endogenous or administered sympathomimetic amines with particular reference to some aspects of the cardiovascular system. Use of in vitro preparations of blood vessels and of other smooth muscles, such as vas deferens and anococcygeus, has thrown light on possible roles for these deaminating enzymes, even in the inactivation of noradrenaline, while the new reversible inhibitors of MAO-A show promise as antidepressants with a reduced risk of hypertensive crises following the ingestion of tyramine-containing food. However, the role of SSAO in the inactivation of amines remains an enigma, even though much is now known of its biochemical nature. While the pharmacological responses to amine substrates can be potentiated by inhibition of SSAO, there is a suspicion that it is product rather than substrate that is more important.

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Plasma catecholamines in arterial and capillary blood

Cited by 21 publications

References 12 publications

Capillary Versus Arterial Plasma Catecholamines as Markers for Sympatho-Adrenal Activity in Infants

Capillary Versus Arterial Plasma Catecholamines as Markers for Sympatho-Adrenal Activity in Infants

Long-Term Stability of Cardiovascular and Catecholamine Responses to Stress Tests

Some Aspects of the Enzymic Inactivation of Sympathomimetic Amines

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