Plasma catecholamines during labour in normal and pre-eclamptic pregnancies

Sammour, Mohamed B.; Ammar, Abeer; Tash, Fathy; Dawoud, S. M.

doi:10.1007/978-94-009-8697-8_24

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…The increase in plasma adrenaline, noradrenaline and dopamine suggests that there is an increased sympathetic nervous system activity in a significant proportion of hypertensive pregnant women. It is supported by the reported increase in urinary catecholamines in pregnancy hypertension (Cession, 1966 ;Zuspan, 1977) and by the recently published observations of increased plasma catecholamines in labour (Sammour et al, 1980) and in plasma adrenaline following exercise (Poland and Lucas, 1980) in pre-eclamptic women. It also provides an explanation for the hyperkinetic cardio-vascular changes in hypertension in pregnancy (Hamilton, 1951;Lim and Walters, 1979;Bendetti et al, 1980).…”

Section: Discussionmentioning

confidence: 73%

Plasma Adrenaline, Noradrenaline and Dopamine in Pregnancy Hypertension

Davey

Macnab

1981

BJOG

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The resting plasma adrenaline, noradrenaline and dopamine were measured in nine hypertensive women and seven normotensive women in the third trimester of pregnancy on two successive days. The mean plasma adrenaline concentrations on the two days in the hypertensive women (442 and 298 pg/ml) were significantly higher than in the normotensive women (43 -9 and 61 * 6 pg/ml). The mean plasma noradrenaline concentrations in the hypertensive women (232 and 274 pg/ml) were higher than in the normotensive women (48 and 110 pg/ml) and the difference was significant on Day 1 but not Day 2. The mean plasma dopamine concentrations in the hypertensive women (98.6 and 62.1 pg/ml) were higher than in the normotensive women (23.2 and 26.0 pg/ml) and the difference was significant on Day 1 but not Day 2. The plasma adrenaline/noradrenaline ratios were significantly increased in the hypertensive compared with the normotensive women on both days. It is suggested that sympathetic nervous system activity may be increased in some women with hypertension in pregnancy.

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Section: Discussionmentioning

confidence: 73%

Plasma Adrenaline, Noradrenaline and Dopamine in Pregnancy Hypertension

Davey

Macnab

1981

BJOG

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“…Some studies have suggested that plasma renin or angiotensin I1 may contribute (Symonds, Broughton Pipkin vasopressin in pregnancy hypertension (Weir, Brown, Fraser, et al, 1973;Skinner, Lumbers & Symonds, 1972;Helmer & Judson, 1967;Weir, Doig, Fraser, Morton, Parboosingh, Robertson & Wilson, 1976). The few reports of plasma catecholamines in pre-eclampsia have shown no consistent pattern (Poland & Lucas, 1980;Sammour, Ammar, Tash & Dawaud, 1980). For none of these substances has a circadian rhythm in pregnancy been established.…”

Section: Introductionmentioning

confidence: 99%

Circadian Rhythms of Blood Pressure and Pressor Hormones in Normal and Hypertensive Pregnancy

Beilin

Deacon

Michael

et al. 1982

Clin Exp Pharmacol Physiol

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1. Circadian patterns of blood pressure and pressor hormones were studied in late pregnancy in ten normotensive women and twenty-one hypertensives. 2. Plasma renin activity, angiotensin II and free adrenaline and noradrenaline leves were highest at 0900 h in normotensives and uncomplicated hypertensives. Catecholamine sulphate levels were lowest at 0900 h. 3. In eight pre-eclamptic hypertensives, plasma renin activity, and angiotensin II were suppressed. 4. Adrenaline sulphate levels were raised in hypertensives. 5. Four pre-eclamptics with noctural hypertension had the highest blood pressures; their diurnal rhythm for noradrenaline sulphate was reversed but they showed no consistent pattern of pressor hormones. However failure of angiotensin II, adrenaline or noradrenaline to fall at night in subjects with increased vascular reactivity could contribute to their nocturnal hypertension.

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Diurnal Rhythms of Blood Pressure, Plasma Renin Activity, Angiotensin II and Catecholamines in Normotensive and Hypertensive Pregnancies

Beilin¹,

J²,

Michael³

et al. 1983

Clinical and Experimental Hypertension. Part B: Hypertension in

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Diurnal patterns of blood pressure and pressor hormones after 26 weeks gestation were compared in 10 normotensive women, 13 subjects with uncomplicated hypertension, and 8 with biochemical evidence of pre-eclampsia. 4 of the pre-eclamptics showed nocturnal hypertension. Levels of plasma renin activity fell progressively from 9 a.m. to midnight in all three groups, and were significantly lower in pre-eclampsia. Plasma angiotensin II levels fell during the day in normotensives and uncomplicated hypertensives, whereas pre-eclamptics showed loss of this pattern and significantly lower levels than the other groups. Free plasma norepinephrine levels fell during the day and to a similar extent in all three groups. A diurnal pattern for free plasma norepinephrine levels, with lower levels at midnight than during the day, was seen in normotensives and uncomplicated hypertensives but not in pre-eclamptics. Plasma norepinephrine sulphate levels rose from 9.00 a.m. to midnight in normotensives and uncomplicated hypertensives. This pattern was reversed in pre-eclamptics, including 3 of the 4 subjects with nocturnal hypertension. Plasma epinephrine sulphate levels rose progressively through the day, with no significant differences between groups. Failure of plasma angiotensin II or epinephrine levels to fall at night in pre-eclampsia may contribute to nocturnal hypertension in subjects with increased vascular reactivity. Suppression of plasma renin activity and angiotensin II levels suggests that perhaps as yet unidentified pressor mechanisms are involved in pre-eclampsia.

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Plasma catecholamines during labour in normal and pre-eclamptic pregnancies

Cited by 4 publications

References 6 publications

Plasma Adrenaline, Noradrenaline and Dopamine in Pregnancy Hypertension

Plasma Adrenaline, Noradrenaline and Dopamine in Pregnancy Hypertension

Circadian Rhythms of Blood Pressure and Pressor Hormones in Normal and Hypertensive Pregnancy

Diurnal Rhythms of Blood Pressure, Plasma Renin Activity, Angiotensin II and Catecholamines in Normotensive and Hypertensive Pregnancies

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