Plasma Adrenaline, Noradrenaline and Dopamine in Pregnancy Hypertension

Davey, D. A.; Macnab, M. F.

doi:10.1111/j.1471-0528.1981.tb01217.x

Cited by 55 publications

(20 citation statements)

References 17 publications

(19 reference statements)

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“…The urinary excretion of noradrenaline in the present study was not different in P-INS rats compared with P animals. These data do not support the presence of increased activity of the sympathetic nervous system ; however, given that extremely variable changes in plasma concentrations and urinary excretion of catecholamines have been reported in hypertensive pregnancies [11][12][13], no definitive conclusion can be reached.…”

Section: Discussioncontrasting

confidence: 47%

Chronic exogenous hyperinsulinaemia-induced hypertension in pregnant rats: effect of chronic treatment with l-arginine

et al. 2001

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Recent studies have shown that maternal hyperinsulinaemia is a risk factor for the development of hypertension in pregnancy. Experimentally, pregnant rats with chronic exogenously induced hyperinsulinaemia (P-INS rats) have increased blood pressure at the end of gestation. This is associated with a blunted elevation of the excretion of the urinary metabolites of nitrate (UNO(x)). In the present study, we aimed to evaluate the mechanism(s) of the increase in blood pressure in this model. Four groups were studied: normal pregnant rats (P rats), P-INS rats, P-INS rats treated with L-arginine (2 g/l in the drinking water) (L-ARG rats) and hyperinsulinaemic virgin rats (V-INS rats). Systolic blood pressure (SBP), UNO(x) excretion (on ingestion of a controlled low-nitrate diet), urine noradrenaline (norepinephrine) and plasma endothelin levels were evaluated. Rats were killed on day 22 of pregnancy. Five P-INS rats were not killed at this time, in order to measure SBP 30 and 60 days after delivery. Fetal number and fetal body weight were evaluated. At the end of pregnancy, a 10+/-3% increase in SBP was found in P-INS rats, contrasting with a fall of -15+/-4% in P rats (P<0.01). In the L-ARG group at the end of pregnancy, SBP values had fallen by -14+/-2%, to values comparable with those of P rats. The increase in UNO(x) excretion was 175+/-38% in P rats, 106+/-12% in L-ARG rats and 41+/-8% in P-INS rats (P<0.01 compared with P and L-ARG groups). No differences were found in the urinary excretion of noradrenaline or in the plasma levels of endothelin-1 between the pregnant groups. Fetal number was similar in all groups, but fetal body weight was lower for P-INS rats compared with P and L-ARG rats. Thus the blood pressure response to L-arginine strongly suggests that a decrease in NO availability may be the main pathogenic mechanism involved in the development of hypertension in this model.

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Section: Discussioncontrasting

confidence: 47%

Chronic exogenous hyperinsulinaemia-induced hypertension in pregnant rats: effect of chronic treatment with l-arginine

et al. 2001

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“…Previous attempts to study autonomic nervous system function by means of plasma and urinary catecholamine concentrations did not give conclusive results. 23,30,31 A substantial increase in sympathetic vasoconstrictor activity has been found by Schobel et al, 1 measuring the postganglionic sympatheticnerve activity in the blood vessels of skeletal muscle. Since five of the nine pre-eclamptic patients received dihydralazine at the time of the study, we have to assume that pre-eclampsia was at a greater level of severity than in our patients.…”

Section: Discussionmentioning

confidence: 91%

Baroreflex control of heart rate is impaired in pre-eclampsia

et al. 1999

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Autonomic nervous dysfunction, such as parasympathetic and sympathetic impairment, has been suggested as possible cause of pre-eclampsia, but the studies are not conclusive. Our purpose was to assess non-invasively if pre-eclampsia is associated with a decreased baroreflex function. Nine women with pre-eclampsia (PE), eight normotensive pregnant women, and seven healthy normotensive non-pregnant women were studied. Continuous finger blood pressure was recorded by a Portapres device in the left lateral recumbent position and active standing. Baroreflex gain was evaluated by

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“…[18][19][20] These conflicting results may be explained by the now wellaccepted fact that plasma and urinary catecholamine levels are insensitive measures of sympathetic activity that are influenced by many factors, such as efferent neural activity, synaptic transmitter release, reuptake mechanisms, and regional blood flow. 21 Pregnancy may lead to changes in catecholamine metabolism and clearance.…”

Section: Discussionmentioning

confidence: 99%