Plasma calcitonin in small cell lung cancer: prognostic significance

Ap, Sappino; Carter, S; Ellison, Morag; Smith, IE

doi:10.1038/bjc.1983.283

Cited by 7 publications

(8 citation statements)

References 4 publications

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“…Liver metastases in 28% of patients in our scries is in agreement with the study of Sappino et al [13] (34%; staging proce dures were not specified) and that of Mulshine et al [35] (26%), where liver assess ment included pathologic staging. They also reported that the staging error made by using liver scintiscans in classifying patients as limited or extensive stage was very small.…”

Section: Site O F Metastasessupporting

confidence: 81%

“…Our experience with 64% of the patients present ing with ED is in agreement with other series. Contrary to the results of Sappino et al [ 13], we report that stage of disease and elevated calcitonin levels are not signifi cantly related.…”

Section: Stage O F Diseasecontrasting

confidence: 57%

“…The strong correlation of elevated calcitonin with liver metastases was also shown by Sap pino et al [13]. The reason for this correla tion is not known.…”

Section: Site O F Metastasesmentioning

confidence: 50%

“…Sappino et al [13] claimed that increased values corre lated with extensive disease, while Hansen et al [9] and Gropp et al [7,14] reported no correlation with stage of disease. While Sap pino et al [ 13] also found a relationship with liver métastasés and Silva et al [15] believed hypercalcitonemia to be often associated with bone métastasés, other authors [8,14] have not been able to relate levels to sites of métas tasés. In addition, Sappino et al [ 13] found a shortened survival, whereas Hansen et al [9] were unable to demonstrate a relationship between survival and pretreatment levels.…”

Section: Introductionmentioning

confidence: 97%

“…Hypercalcemia in SCC is rare and its pres ence is usually associated with metastases to bone [6,13]. In the study by Lueg and Barkman [34], only 3/41 patients with SCC were hypercalcemic, and only 1 of the 3 patients had bone metastases.…”

Section: Site O F Metastasesmentioning

confidence: 99%

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Imaging Studies and the Prognostic Value of Serum Calcitonin in Staging Small-Cell Lung Cancer

Samuels¹,

Cameron²,

Hirte³

et al. 1987

Tumor Biol

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The controversial prognostic significance of serum calcitonin in small-cell lung cancer (SCC) prompted this retrospective study relating serum levels to (1) stage of disease [limited disease (LD) vs. extensive disease (ED)], (2) imaging studies of metastases to bone, liver, and brain, and (3) survival. Of the 127 previously untreated patients with SCC presenting from 1979 to 1984, calcitonin levels could be compared to the stage of the disease in 69 patients (25 LD and 44 ED) and to various staging procedures including ^99mTc methylene diphosphonate bone scans (63 patients), ^99mTc sulfur colloid liver-spleen scans (64 patients), computed tomography of the head (63 patients) and serum calcium (61 patients). 71% (49/69) of patients had elevated calcitonin of whom 65% (32/49) had ED. 29% (20/69) had normal levels of whom 60% (12/20) had ED. 40% (18/45) of patients with raised calcitonin had liver metastases. 100% (19/19) with normal calcitonin had no liver involvement. Two patients with hypercalcemia and increased calcitonin had extensive bony metastases. The survival experiences of patients with normal and elevated serum calcitonin levels were analyzed. No significant differences were found within each stage or in the group overall. The positive correlation of serum calcitonin to liver metastases was statistically significant. No such relationship could be demonstrated with stage of disease, bone metastases, brain metastases, or survival.

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Section: Site O F Metastasessupporting

confidence: 81%

Section: Stage O F Diseasecontrasting

confidence: 57%

“…The strong correlation of elevated calcitonin with liver metastases was also shown by Sap pino et al [13]. The reason for this correla tion is not known.…”

Section: Site O F Metastasesmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 97%

Section: Site O F Metastasesmentioning

confidence: 99%

See 3 more Smart Citations

Imaging Studies and the Prognostic Value of Serum Calcitonin in Staging Small-Cell Lung Cancer

Samuels¹,

Cameron²,

Hirte³

et al. 1987

Tumor Biol

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Calcitonin in human gastric mucosa and carcinoma

Ito

Hata

Yokozaki

et al. 1986

J Cancer Res Clin Oncol

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The localization of immunoreactive calcitonin (IR-CT) in the human gastric mucosa and tumor tissues was studied using an immunohistochemical peroxidase-antiperoxidase method. A small number of IR-CT-containing cells were observed in both infant and adult gastric antral mucosa and the ratio of IR-CT-containing cells to G cells was about 1:50-100. Moreover, tissue content of IR-CT in normal antral mucosa was 2.37 +/- 0.35 ng/g wet weight. IR-CT-containing cells and G cells decreased with the progress of chronic atrophic gastritis and were totally absent in intestinal metaplastic glands. IR-CT was detected in G cells, suggesting a paracrine relation between gastrin and CT. IR-CT was not found in tumor cells of 35 gastric adenomas and 40 well differentiated adenocarcinomas. On the other hand, it was demonstrated in a very small number of tumor cells in 4 of 46 poorly differentiated adenocarcinomas, and in a good number in 3 of 7 scirrhous argyrophil cell carcinomas. IR-CT in plasma could serve, therefore, as a tumor marker of scirrhous endocrine cell carcinoma, and its production in cancer cells was considered to be eutopic rather than ectopic.

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Serum markers of pulmonary endocrine neoplasms

Gosney

1992

Pulmonary Endocrine Pathology

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Plasma calcitonin in small cell lung cancer: prognostic significance

Cited by 7 publications

References 4 publications

Imaging Studies and the Prognostic Value of Serum Calcitonin in Staging Small-Cell Lung Cancer

Imaging Studies and the Prognostic Value of Serum Calcitonin in Staging Small-Cell Lung Cancer

Calcitonin in human gastric mucosa and carcinoma

Serum markers of pulmonary endocrine neoplasms

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