Plasma C-reactive protein levels and their relationship to anthropometric and lipid characteristics among children

Wu, Der-Min; Chu, Nain-Feng; Shen, Muh-Han; Chang, Jia-Kan

doi:10.1016/s0895-4356(02)00519-x

Cited by 45 publications

(37 citation statements)

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“…In this representative sample of Spanish adolescents, CRP concentrations were significantly associated with overweight and obesity in both females and males. These results are in consonance with a study of a large sample of American children and adolescents, and several other studies on children, [15][16][17][18] and extend previous research showing that CRP and BMI were strongly associated in adults. 19 Cytokines are difficult to predict and to measure, and there are no reference values in order to establish their variability in a healthy population as the one tested in this Inflammation in overweight adolescents J Wärnberg et al study.…”

Section: Discussionsupporting

confidence: 92%

Inflammatory mediators in overweight and obese Spanish adolescents. The AVENA Study

et al. 2004

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OBJECTIVE:The aim of this study was to clarify if there is an association between overweight and a state of chronic, low-grade inflammation in adolescents. DESIGN: The study is a part of the cross-sectional multicenter study AVENA, designed to evaluate the nutritional status of a representative sample of Spanish adolescents. The adolescents were divided into two groups: (1) nonoverweight and (2) overweight/obesity using the International Obesity Task Force (IOTF) standards. SUBJECTS: A geographically representative subsample of the AVENA study including 493 Spanish adolescents, aged 13-18 y (236 females/257 males), participated in this study. MEASUREMENTS: Serum C-reactive protein (CRP) and in vitro production of interleukin 6 and tumor necrosis factor a were measured, together with a detailed anthropometry. RESULTS: The inflammatory markers showed generally higher values in subjects with overweight/obesity than in those with nonoverweight, with only CRP showing significant differences (the means were 0.83 and 1.27 mg/l in the nonoverweight and overweight/obesity groups, respectively). CONCLUSION: Although we have not studied if adolescent overweight and obesity play an initiating role in the development of future diseases, we suggest it may induce a chronic low-grade inflammatory state, which points out the importance of maintaining an appropriate body weight, to avoid obesity-related diseases in adulthood.

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Section: Discussionsupporting

confidence: 92%

Inflammatory mediators in overweight and obese Spanish adolescents. The AVENA Study

et al. 2004

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“…A study of English schoolchildren aged 10 -11 years found an association between CRP levels and both HDL cholesterol and SBP (7), but those data may have been influenced by a large cohort of Southeast Asian children with high CRP levels and insulin resistance. A relationship was found between CRP and HDL cholesterol levels in 835 children from Taipei aged 12-16 years (11). A study of 79 Finnish children showed no significant relationship between CRP levels and blood pressure or lipid levels (29).…”

Section: Resultsmentioning

confidence: 94%

“…Several studies have related CRP levels to the degree of adiposity in adults (3,5) and children (7)(8)(9)(10)(11)(12)28). CRP was related to BMI and adiposity in Hispanic children as young as 2 years of age (12).…”

Section: Resultsmentioning

confidence: 99%

“…Although CRP is known to be associated with adiposity in youth (7)(8)(9)(10)(11)(12), there are no data relating it to insulin resistance in children or adolescents. These data may be important because the insulin resistance syndrome has its origins in youth (13)(14)(15) and the independent roles of insulin resistance and adiposity in establishment of the syndrome (and in ongoing development from childhood into adulthood) have not been defined.…”

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confidence: 99%

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Relation of C-Reactive Protein to Insulin Resistance and Cardiovascular Risk Factors in Youth

et al. 2005

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OBJECTIVE -Insulin resistance and C-reactive protein (CRP) levels are strongly correlated in adults. This study explored the relationship in youth.RESEARCH DESIGN AND METHODS -Associations between CRP levels, cardiovascular risk, and insulin resistance measured by the euglycemic clamp were investigated in 342 healthy Minneapolis youth.RESULTS -There was no difference in mean CRP levels among boys (n ϭ 189, CRP 1.10 Ϯ 0.46 mg/l) and girls (n ϭ 153, CRP 1.16 Ϯ 0.63 mg/l; P ϭ 0.32). There was also no difference between CRP and Tanner stage. CRP, adjusted for BMI, was significantly greater in black subjects compared with white subjects (P ϭ 0.03). CRP was strongly related to adiposity in both girls and boys. CRP levels were related to fasting insulin levels (r ϭ 0.16, P ϭ 0.003) but this association was not significant after adjustment for BMI (r ϭ 0.07, P ϭ 0.21). Similarly, M, the euglycemic clamp measurement of insulin sensitivity, was significantly related to CRP levels (r ϭ Ϫ0.13, P ϭ 0.02) but not when M was normalized to lean body mass (M lbm ) (r ϭ Ϫ0.10, P ϭ 0.09). There was a significant inverse correlation between M lbm and CRP quartiles, which disappeared after adjustment for BMI. There was no significant association between CRP levels and lipids, blood pressure, physical activity, or left ventricular mass.CONCLUSIONS -In contrast to adult subjects, after adjustment for adiposity, CRP levels in children age 10 -16 years were not significantly associated with insulin resistance or with other factors comprising the metabolic syndrome. This is consistent with the concept that insulin resistance may precede the development of CRP elevation in the evolution of the metabolic syndrome. Diabetes Care 28:1763-1768, 2005C -reactive protein (CRP) is an acutephase reactant usually associated with serious infection and inflammation. More recently, it has become clear that subtle elevation of CRP levels within the "normal" adult range is an indicator of subclinical disease, such as that related to 1) the risk of cardiovascular disease in healthy men and women and in individuals with type 1 diabetes (1), 2) the risk factors associated with the metabolic syndrome (1-3), and 3) the onset of type 2 diabetes (4). The mechanisms accounting for these relations are not well understood.Insulin resistance and CRP levels are strongly correlated in adults (2,3,5,6). Although CRP is known to be associated with adiposity in youth (7-12), there are no data relating it to insulin resistance in children or adolescents. These data may be important because the insulin resistance syndrome has its origins in youth (13-15) and the independent roles of insulin resistance and adiposity in establishment of the syndrome (and in ongoing development from childhood into adulthood) have not been defined. If inflammation is a precursor to cardiovascular disease, determining these early relations would be highly relevant to the design of further investigation and prevention strategies. As recently suggested (16), this developmental period might be p...

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“…Hepcidin is severely affected by anemia parameters such as serum and storage iron levels of patients regardless of the level of inflammation. Body weight and body mass index are very important factors affecting hepcidin and the levels of other biochemical markers (28,29). These factors were not compared between the groups in our study.…”

Section: Discussionmentioning

confidence: 84%

Role of hepcidin in the diagnosis of sepsis and septic shock in children

2018

Turk J Med Sci

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Plasma C-reactive protein levels and their relationship to anthropometric and lipid characteristics among children

Cited by 45 publications

References 35 publications

Inflammatory mediators in overweight and obese Spanish adolescents. The AVENA Study

Inflammatory mediators in overweight and obese Spanish adolescents. The AVENA Study

Relation of C-Reactive Protein to Insulin Resistance and Cardiovascular Risk Factors in Youth

Role of hepcidin in the diagnosis of sepsis and septic shock in children

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