Role of hepcidin in the diagnosis of sepsis and septic shock in children

doi:10.3906/sag-1707-120

Cited by 1 publication

(1 citation statement)

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“…These studies reported that hepcidin levels in serum were raised in sepsis patients. In a study including pediatric patients three groups of children were represented, 44 with sepsis and septic shock, 17 children treated in the ICU with no infection and 28 healthy children, reported that PCT and hepcidin levels were superior to discriminate between infected and non-infected children than CRP and WBC 42 . In a study by Yan et al .…”

Section: Discussionmentioning

confidence: 99%

Hepcidin discriminates sepsis from other critical illness at admission to intensive care

Olinder

Börjesson

Norrman

et al. 2022

Sci Rep

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Initial differential diagnosis and prognosis for patients admitted to intensive care with suspected sepsis remain arduous. Hepcidin has emerged as a potential biomarker for sepsis. Here we report data on the relevance of levels of hepcidin versus other biomarkers as a diagnostic and prognostic tool for sepsis. 164 adult patients admitted to the intensive care unit (ICU) within 24 h upon arrival to the hospital were included. Blood samples collected daily for seven consecutive days and hepcidin levels, heparin binding protein (HBP) levels and standard biomarkers were determined. Blood cultures were initiated at inclusion. Clinical scores were evaluated daily and mortality after 28- and 180-days was recorded. One hundred of the patients were found to fulfil the criteria for sepsis whereas 64 did not. Hepcidin levels at admission were significantly higher in the septic than in the non-septic patients. In septic patients hepcidin levels declined significantly already at 24 h followed by a steady decline. A significant negative correlation was observed between hepcidin levels and SAPS 3 in patients with sepsis. Hepcidin levels at inclusion were significantly higher among septic patients that survived 180-days and predicted mortality. Our data show that hepcidin levels are indicative of sepsis in patients admitted to the ICU and has a prognostic value for mortality.

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Section: Discussionmentioning

confidence: 99%