Plasma C-peptide level is inversely associated with family history of type 2 diabetes in Korean type 2 diabetic patients

Chung, Jin Ook; Cho, Dong Hyeok; Chung, Dong Jin; Chung, Min Young

doi:10.1507/endocrj.k10e-175

Cited by 10 publications

(12 citation statements)

References 36 publications

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“…The association between positive family history and low c-peptide levels, consistent with impaired β cell function, remained significant after adjustment for age, gender, duration of diabetes, BMI, fasting plasma glucose, and free fatty acid levels 81. In another Korean study that examined the ratio of β cell to α cells in islets from donors, a positive relationship was found between BMI and β cell mass 82.…”

Section: Pathophysiology Of Type 2 Diabetes In East Asiansmentioning

confidence: 88%

Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States

Chan

2013

Annals of the New York Academy of Sciences

656

590

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There is an epidemic of diabetes in Asia. Type 2 diabetes develops in East Asian patients at a lower mean body mass index (BMI) compared with those of European descent. At any given BMI, East Asians have a greater amount of body fat and a tendency to visceral adiposity. In Asian patients, diabetes develops at a younger age and is characterized by early β cell dysfunction in the setting of insulin resistance, with many requiring early insulin treatment. The increasing proportion of young-onset and childhood type 2 diabetes is posing a particular threat, with these patients being at increased risk of developing diabetic complications. East Asian patients with type 2 diabetes have a higher risk of developing renal complications than Europeans and, with regard to cardiovascular complications, a predisposition for developing strokes. In addition to cardiovascular–renal disease, cancer is emerging as the other main cause of mortality. While more research is needed to explain these interethnic differences, urgent and concerted actions are needed to raise awareness, facilitate early diagnosis, and encourage preventive strategies to combat these growing disease burdens.

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Section: Pathophysiology Of Type 2 Diabetes In East Asiansmentioning

confidence: 88%

Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States

Chan

2013

Annals of the New York Academy of Sciences

656

590

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“…If all genes related to diabetes have an OR of 1.2 or less, which under the common disease/common variant hypothesis appears probable, then the total number of genes required to account for the estimated heritability is between 200 and 800 (40). As such, the use of genes to predict diabetes is not as operative as phenotypic risk factors and family history (30,150).…”

Section: Genetic Risk Factorsmentioning

confidence: 99%

Type 2 Diabetes in Asians: Prevalence, Risk Factors, and Effectiveness of Behavioral Intervention at Individual and Population Levels

et al. 2012

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This review summarizes the current data on diabetes risk factors, prevalence, and prevention efforts in Asia and Asian migrant populations. Studies indicate that type 2 diabetes mellitus is a large and growing threat to public health in Asian populations. Furthermore, Asian subgroups (e.g., South Asians/Asian Indians, Chinese) have unique risk factor profiles for developing diabetes, which differ from other populations and between Asian ethnic groups. Lifestyle intervention programs are effective in preventing diabetes in Asians, as with other ethnicities. The strength of these findings is lessened by the lack of systematically collected data using objective measurements. Large epidemiologic studies of diabetes prevalence and risk factor profiles and translational trials identifying sustainable and culturally acceptable lifestyle programs for Asian subgroups are needed.

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“…For example, in previous studies examining the effect of FHD in detail, insulin secretion was reported to be impaired in non‐diabetic relatives with parental diabetes, and such defects seemed to have been inherited, although insulin resistance was not impaired. However, as FHD is not often considered after the onset of diabetes, only a few studies have evaluated the effects of FHD on residual β‐cell function in type 2 diabetes patients with longer durations of diabetes, and these studies have reported conflicting conclusions. One study reported that the level of fasting serum C‐peptide immunoreactivity (F‐CPR) was significantly lower in patients with FHD than in those without FHD.…”

Section: Introductionmentioning

confidence: 99%

“…However, as FHD is not often considered after the onset of diabetes, only a few studies have evaluated the effects of FHD on residual β‐cell function in type 2 diabetes patients with longer durations of diabetes, and these studies have reported conflicting conclusions. One study reported that the level of fasting serum C‐peptide immunoreactivity (F‐CPR) was significantly lower in patients with FHD than in those without FHD. In contrast, two other studies showed that the presence/absence of FHD had little influence on the level of F‐CPR.…”

Section: Introductionmentioning

confidence: 99%

Family history of diabetes in both parents is strongly associated with impaired residual β‐cell function in Japanese type 2 diabetes patients

Iwata

Kamura

Honoki

et al. 2019

J of Diabetes Invest

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Aims/Introduction: The objective of the present study was to clarify the association of the type and number of first-degree family history of diabetes (FHD) with the clinical characteristics, especially with residual b-cell function, in type 2 diabetes patients. Materials and Methods: A total of 1,131 type 2 diabetes patients were recruited and divided into four groups according to FHD information as follows: (i) patients without FHD (FHD-); (ii) those with at least one sibling who had diabetes without parental diabetes (FHD+); (iii) those with one parent (FHD++); or (iv) those with both parents (FHD+++) who had diabetes with or without a sibling with diabetes. Results: The percentages of the FHD-, FHD+, FHD++ and FHD+++ groups were 49.4%, 13.4%, 34.0% and 3.2%, respectively. Patients in the FHD++ and FHD+++ groups were significantly younger at the time of diabetes diagnosis (P < 0.001) than those in the FHDand FHD+ groups, even after adjusting for confounding factors. In addition, the levels of insulin secretion were significantly lower in the patients in the FHD+, FHD++ and FHD+++ groups than those in the FHD-group (P < 0.05) after adjusting for confounding factors, and the patients in the FHD+++ group presented with the lowest levels of insulin secretion among the four groups. Conclusions: Our results showed that in type 2 diabetes patients, the degree of the associations between FHD and clinical characteristics differs according to the number and the type of FHD. In particular, FHD in both parents is most strongly associated with impaired residual b-cell function.

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Plasma C-peptide level is inversely associated with family history of type 2 diabetes in Korean type 2 diabetic patients

Cited by 10 publications

References 36 publications

Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States

Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States

Type 2 Diabetes in Asians: Prevalence, Risk Factors, and Effectiveness of Behavioral Intervention at Individual and Population Levels

Family history of diabetes in both parents is strongly associated with impaired residual β‐cell function in Japanese type 2 diabetes patients

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