Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma

Sreter, Katherina Bernadette; Popović‐Grle, Sanja; Lampalo, Marina; Konjevod, Marcela; Tudor, Lucija; Perković, Matea Nikolac; Jukić, Irena; Bingulac-Popović, Jasna; Stanić, Hana Safić; Markeljević, Jasenka; Pivac, Nela; Štrac, Dubravka Švob

doi:10.3390/jpm10040189

Cited by 8 publications

(12 citation statements)

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“…Studies showed that IL4 , a key effector Th2 cytokine in allergic asthma, was essential for B cells autophagy induction in vivo and in vitro , thereby further sustaining B cell survival and enhanced B cell antigen presentation ( 73 ). BDNF may contribute to normal lung function and immune response and may serve as a potential peripheral biomarker for asthma, especially that is aspirin-sensitive ( 74 ). Studies have shown that SPINK5 has biological actions other than protease inhibition, which may be related to the pathogenesis of asthma ( 75 ).…”

Section: Resultsmentioning

confidence: 99%

Perinatal Exposure to Nicotine Alters Sperm RNA Profiles in Rats

et al. 2022

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Perinatal exposure to smoking has been associated with childhood asthma, one of the most common pediatric conditions affecting millions of children globally. Of great interest, this disease phenotype appears heritable as it can persist across multiple generations even in the absence of persistent exposure to smoking in subsequent generations. Although the molecular mechanisms underlying childhood asthma induced by perinatal exposure to smoking or nicotine remain elusive, an epigenetic mechanism has been proposed, which is supported by the data from our earlier analyses on germline DNA methylation (5mC) and histone marks (H3 and H4 acetylation). To further investigate the potential epigenetic inheritance of childhood asthma induced by perinatal nicotine exposure, we profiled both large and small RNAs in the sperm of F1 male rats. Our data revealed that perinatal exposure to nicotine leads to alterations in the profiles of sperm-borne RNAs, including mRNAs and small RNAs, and that rosiglitazone, a PPARγ agonist, can attenuate the effect of nicotine and reverse the sperm-borne RNA profiles of F1 male rats to close to placebo control levels.

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Section: Resultsmentioning

confidence: 99%

Perinatal Exposure to Nicotine Alters Sperm RNA Profiles in Rats

et al. 2022

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“…The control group consisted of volunteer blood donors recruited at the Croatian Institute for Transfusion Medicine, Zagreb, Croatia. The inclusion and exclusion criteria for enrolment of the subjects in the study have previously been outlined in detail [53]. Data regarding age, gender, body mass index (BMI), and smoking were collected for all subjects.…”

Section: Participantsmentioning

confidence: 99%

“…Skin prick testing (SPT), spirometry with bronchodilation, single-breath diffusing capacity of the lung for carbon monoxide (DLCO) test and fractional exhaled nitric oxide (FeNO) measurement were performed. The forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC), and peak expiratory flow (PEF) were calculated as stated previously [53]. The eosinophil and neutrophil counts were obtained from automated complete blood counts.…”

Section: Participantsmentioning

confidence: 99%

“…In contrast, serum immunoglobulin E (IgE) levels were measured using enzymeamplified chemiluminescent immunoassays (Immulite ® 2000XPi, Siemens Healthcare Diagnostics, Erlangen, Germany), according to the manufacturer's procedures. As already described [53], asthma patients were subdivided into non-severe (mild-to-moderate) and severe asthma patients [1], as well as into patients with non-allergic and allergic asthma [54], eosinophilic and non-eosinophilic asthma [55], type 2 (T2)-high and T2-low asthma [56][57][58][59], and asthma patients with and without aspirin-exacerbated respiratory disease (AERD) [60]…”

Section: Participantsmentioning

confidence: 99%

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Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma

Konjevod

Sreter²,

Popović‐Grle

et al. 2023

Biomolecules

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The complex role of the serotonin system in respiratory function and inflammatory diseases such as asthma is unclear. Our study investigated platelet serotonin (5-HT) levels and platelet monoamine oxidase B (MAO-B) activity, as well as associations with HTR2A (rs6314; rs6313), HTR2C (rs3813929; rs518147), and MAOB (rs1799836; rs6651806) gene polymorphisms in 120 healthy individuals and 120 asthma patients of different severity and phenotypes. Platelet 5-HT concentration was significantly lower, while platelet MAO-B activity was considerably higher in asthma patients; however, they did not differ between patients with different asthma severity or phenotypes. Only the healthy subjects, but not the asthma patients, carrying the MAOB rs1799836 TT genotype had significantly lower platelet MAO-B activity than the C allele carriers. No significant differences in the frequency of the genotypes, alleles, or haplotypes for any of the investigated HTR2A, HTR2C and MAOB gene polymorphisms have been observed between asthma patients and healthy subjects or between patients with various asthma phenotypes. However, the carriers of the HTR2C rs518147 CC genotype or C allele were significantly less frequent in severe asthma patients than in the G allele carriers. Further studies are necessary to elucidate the involvement of the serotonergic system in asthma pathophysiology.

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“…Широкая распространенность и трудность контроля течения хронических воспалительных заболеваний дыхательных путей, включая бронхиальную астму (БА) и хроническую обструктивную болезнь легких (ХОБЛ), указывает на необходимость выявления новых терапевтических мишеней [1,2]. В последние годы наблюдается интерес к изучению не только нейроиммунных механизмов хронизации воспаления в бронхолегочной системе [3,4], но и метаболических изменений, обусловленных нарушениями состава жирных кислот (ЖК) мембран клеток и синтеза липидных медиаторов, участвующих в разрешении острого воспаления [5][6][7]. Дисбаланс иммунной и метаболической систем имеет тесную двустороннюю взаимосвязь [8].…”

Section: Introductionunclassified

Medium and long chain free fatty acid receptors in the pathophysiology of respiratory diseases

Kytikovа

Новгородцева

Denisenko

et al. 2021

Bûlletenʹ fiziologii i patologii dyhaniâ

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Chronic inflammatory diseases of the respiratory tract, including asthma and chronic obstructive pulmonary disease, are a global problem of our time due to the widespread prevalence and difficulty of controlling the course. The mechanism of chronic inflammation in the bronchopulmonary system is closely related to metabolic disorders of lipids and their derivatives. Lipids and their mediators play both a pro-inflammatory and anti-inflammatory role in chronic inflammatory bronchopulmonary pathology. In particular, free fatty acids (FFAs) perform important signaling and regu latory functions in the body, coordinating metabolic and immune relationships. The mechanism that potentially binds FFAs and inflammatory reactions involves the activation of their receptors (FFAR – free fatty acid receptor), which are expressed on the cells of the respiratory tract, as well as on nerve and immune cells. Currently, FFARs are considered attractive targets in the treatment of chronic bronchopulmonary pathology, since modulation of their activity through the use of alimentary polyunsaturated fatty acids (PUFA) can affect the activity and resolution of neuroimmune inflammation in the bronchopulmonary system. However, controversial issues regarding their effectiveness and dose standardization of PUFA continue to limit their widespread use. This review summarizes the literature data on the role of medium- and longchain FFAs in the body’s immunoregulation in normal conditions and in chronic bronchopulmonary pathology. Data on medium and long chain FFA receptors – FFAR1 and FFAR4, FFAR-mediated signaling pathways in the regulation of metabolism and immune responses are systematized. The perspective and complex issues of the use of fatty acids in the treatment of chronic bronchopulmonary pathology are discussed.

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Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma

Cited by 8 publications

References 81 publications

Perinatal Exposure to Nicotine Alters Sperm RNA Profiles in Rats

Perinatal Exposure to Nicotine Alters Sperm RNA Profiles in Rats

Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma

Medium and long chain free fatty acid receptors in the pathophysiology of respiratory diseases

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