Plasma .BETA.-Carotene, Retinol, and .ALPHA.-Tocopherol Levels in Relation to Glycemic Control of Children with Insulin-Dependent Diabetes Mellitus.

Hozumi, Masatoshi; Murata, Takuji; Morinobu, Takao; Manago, Mitsuhiro; Kuno, Tomoko; Tokuda, Masakuni; Konishi, Kazutaka; Zheng, Mingming; Tamai, Hiroshi

doi:10.3177/jnsv.44.1

Cited by 21 publications

(15 citation statements)

References 22 publications

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“…In cases of poorly controlled IDDM, there is a lower bioavailability of retinol . However, the high levels of b-carotene and vitamin E that have been observed in patients with IDDM could be beneficial as antioxidants, although they seem insufficient to prevent oxidative damage (Hozumi et al, 1998). This hypothesis is supported by the detection of an increase among children with IDDM in oxidative stress in plasma (Sato et al, 1979), in low-density lipoproteins (Tsai et al, 1994) and in erythrocytes (Jain et al, 1989).…”

Section: Introductionsupporting

confidence: 66%

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Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus

et al. 2002

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Objective: A case -control study was conducted to evaluate the effects of type 1 diabetes mellitus (IDDM) on plasma levels of vitamin A (retinol) and serum levels of retinol-binding protein (RBP) and their relationship with the atherogenic indicators. Subjects: A total of 47 randomised IDDM children were recruited from those treated at the Endocrinology Unit of the University Hospital of Granada (Spain). They were matched for age and sex with 16 healthy children. Methods: The following parameters were measured in all patients: serum concentrations of total cholesterol, triglycerides, high (HDL, spectrophotometry), very low (VLDL) and low (LDL) density lipoprotein cholesterol (Friedewald's formula); serum levels of RBP (kinetic nephelometry); plasma vitamin A and glycosilated haemoglobin (HbA1c; high performance chromatography). Results: Higher RBP concentrations in IDDM children (P ¼ 0.05), lower retinol levels (P ¼ 0.05) and lower vitamin A=cholesterol ratio (P ¼ 0.02) than in the control group were found; no differences in the atherogenic indicators were observed. There was a correlation between RBP and vitamin A (P ¼ 0.0001). Relationships between retinol, RBP and atherogenic indicators were demonstrated in the IDDM group (A-LDLc=HDLc (P ¼ 0.01); A-(VLDL þ LDL)c=HDLc (P ¼ 0.007); RBP-LDLc=HDLc (P ¼ 0.05); RBP-(VLDL þ LDL)c=HDLc (P ¼ 0.02)), and an inverse relationship was found between the vitamin A=TG ratio and HbA1c (P ¼ 0.004). The children with HbA1c > 8% showed increased atherogenic indicators and lower vitamin A=CHOL and vitamin A=TG ratios than those with good control of the illness. Conclusions: The IDDM children with poor metabolic control face a higher atherogenic risk and vitamin A 'relative deficiency' risk than those with good metabolic control of their illness. Relationships between retinol and RBP with atherogenic indicators were found. The results suggest that vitamin A therapeutic supplements in IDDM children may reduce or prevent atherogenic risk.

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Section: Introductionsupporting

confidence: 66%

“…Nevertheless, another study has shown that totally different results are obtained with diabetic children; no differences in plasma concentrations of retinol were found between the diabetic children and a control group (Hozumi et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus

et al. 2002

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“…nutrients, including b-carotene (20,28,81-85) and a-tocopherol concentrations, possibly as a result of a reduced intake of FV or entrapment in adipose tissue (86,87). Moreover, a recent RCT in children demonstrated significant inverse correlations between b-carotene and BMI, HOMA-IR, the leptin:adiponectin ratio, and abdominal fat mass (88).…”

Section: Discussionmentioning

confidence: 94%

Serum Antioxidant Concentrations and Metabolic Syndrome Are Associated among U.S. Adolescents in Recent National Surveys

Beydoun

Canas

Beydoun

et al. 2012

The Journal of Nutrition

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Specific micronutrients, including retinol, retinyl esters, carotenoids [α-carotene, β-carotene (cis+trans), β-cryptoxanthin, lutein+zeaxanthin, and total lycopene], vitamin E, and vitamin C have antiinflammatory and antioxidant effects, properties shown to reduce oxidative stress, a process that accompanies the pathogenesis of many chronic diseases. It is still largely unknown whether they are associated with the occurrence of metabolic syndrome (MetS) in the adolescent U.S. population. MetS was defined by the International Diabetes Federation (IDF) criteria. Other non-MetS outcomes relying on blood measurements were elevated HOMA-IR, C-reactive protein (CRP), and hyperuricemia. We tested associations between serum antioxidants and MetS outcomes among adolescents aged 12-19 y using cross-sectional data from NHANES 2001-2006 (n = 782-4285). IDF MetS prevalence was estimated at 7% among boys and 3% among girls. In adjusted models, adolescents with MetS had consistently lower carotenoid concentrations compared with their counterparts without MetS. Total carotenoids were also inversely related to HOMA-IR and CRP. Vitamin C was inversely related to uric acid level and MetS binary outcome. Retinol+retinyl esters exhibited an inverse relationship with CRP and a positive relationship with uric acid and HOMA-IR as well as MetS binary outcome. Vitamin E had no association with MetS, particularly after controlling for serum cholesterol and TG. In conclusion, among U.S. adolescents, serum carotenoid concentrations were inversely associated with MetS status, HOMA-IR, and CRP, whereas serum vitamin C was inversely related to MetS status and serum uric acid. Vitamin E had no consistent association with MetS, whereas retinol+retinyl esters had a positive relationship with HOMA-IR, uric acid, and MetS, while being inversely related to CRP. These associations need further study.

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“…According to Hozumi et al study, there is a significant reverse correlation between serum concentration of b-carotene and the serum HbA1c in diabetic subjects [27]. It was also demonstrated that impaired insulin sensitivity has a link with the low serum concentration of b-carotene [28].…”

Section: Carotenoids Intake and The Incidence Of Diabetes Mellitusmentioning

confidence: 97%

Carotenoids in the treatment of diabetes mellitus and its complications: A mechanistic review

Roohbakhsh

Karimi

Iranshahi

2017

Biomedicine & Pharmacotherapy

104

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Plasma .BETA.-Carotene, Retinol, and .ALPHA.-Tocopherol Levels in Relation to Glycemic Control of Children with Insulin-Dependent Diabetes Mellitus.

Abstract: Plasma ƒÀ-carotene, ƒ¿-tocopherol and retinol were measured * p<0 .01 compared to control.

Cited by 21 publications

References 22 publications

Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus

Vitamin A, retinol binding protein and lipids in type 1 diabetes mellitus

Serum Antioxidant Concentrations and Metabolic Syndrome Are Associated among U.S. Adolescents in Recent National Surveys

Carotenoids in the treatment of diabetes mellitus and its complications: A mechanistic review

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