Plasma apelin-12 levels may predict in-hospital major adverse cardiac events in ST-elevation myocardial infarction and the relationship between apelin-12 and the neutrophil/lymphocyte ratio in patients undergoing primary coronary intervention

Topuz, Mustafa; Öz, Fahrettin; Akkuş, Oğuz; Şen, Ömer; Topuz, Ayşe Nur; Bulut, Atilla; Özbiçer, Süleyman; Okar, Sefa; Koç, Mevlüt; Gür, Mustafa

doi:10.1177/0267659116676335

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…Similar to stable CAD patients, elevated NLR prognosticates adverse outcome in ACS patients as shown by several studies both at short term, i.e., <30 days (88, 89, 91, 97–99), and long term, i.e., >6 months, of follow-up (74, 75, 83, 89, 91–93, 97, 102) with an average fourfold increased risk. Only in two studies, the NLR was not independently associated with MACE and CVD mortality (87, 90).…”

Section: Neutrophil To Lymphocyte Ratiomentioning

confidence: 75%

Prognostic Value of Circulating Inflammatory Cells in Patients with Stable and Acute Coronary Artery Disease

Meeuwsen

Wesseling

Hoefer

et al. 2017

Front. Cardiovasc. Med.

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Atherosclerosis is a lipid driven chronic inflammatory disease underlying the majority of ischemic events such as myocardial infarction or stroke. Clinical management of ischemic events has improved considerably in the past decades. Accordingly, survival rates have increased. Nevertheless, 12% of patients die within 6 months after the initial event. To improve secondary prevention, appropriate risk prediction is key. However, up to date, there is no clinically available routine marker to identify patients at high risk for recurrent cardiovascular events. Due to the central role of inflammation in atherosclerotic lesion progression and destabilization, many studies have focused on the role of circulating inflammatory cells in these processes. This review summarizes the current evidence on the potential of circulating inflammatory cells as biomarkers for recurrent adverse manifestations in acute coronary syndrome and stable coronary artery disease patients.

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Section: Neutrophil To Lymphocyte Ratiomentioning

confidence: 75%

Prognostic Value of Circulating Inflammatory Cells in Patients with Stable and Acute Coronary Artery Disease

Meeuwsen

Wesseling

Hoefer

et al. 2017

Front. Cardiovasc. Med.

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“…Liu and colleagues 36 have demonstrated the effect of serum apelin-12 in predicting 1 year outcomes following pPCI in patients with STEMI. Topuz and colleagues 37 found lower levels of serum apelin-12 predicts higher incidence of in-hospital MACEs after multivariate regression analysis and is more likely in no-reflow versus normal flow group. This is a result of NO-dependent vasodilatation caused by apelin-12 in clinical studies 38 as well as in animal models.…”

Section: Discussionmentioning

confidence: 97%

Predictive value of apelin-12 in patients with ST-elevation myocardial infarction with different renal function: a prospective observational study

Yang

Zheng

et al. 2017

BMJ Open

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ObjectivesTo investigate factors predicting the onset of major adverse cardiovascular events (MACEs) after primary percutaneous coronary intervention (pPCI) for patients with ST-segment elevation myocardial infarction (STEMI).BackgroundApelin-12 plays an essential role in cardiovascular homoeostasis. However, current knowledge of its predictive prognostic value is limited.Methods464 patients with STEMI (63.0±11.9 years, 355 men) who underwent successful pPCI were enrolled and followed for 2.5 years. Multivariate cox regression analysis and receiver operating characteristic (ROC) curve analysis were performed to determine the factors predicting MACEs.Results118 patients (25.4%) experienced MACEs in the follow-up period. Multivariate cox regression analysis found low apelin-12 (HR=0.132, 95% CI 0.060 to 0.292, P<0.001), low left ventricular ejection fraction (HR=0.965, 95% CI 0.941 to 0.991, P=0.007), low estimated glomerular filtration rate (eGFR) (HR=0.985, 95% CI 0.977 to 0.993, P<0.001), Killip’s classification>I (HR=0.610, 95% CI 0.408 to 0.912, P=0.016) and pathological Q-wave (HR=1.536, 95% CI 1.058 to 2.230, P=0.024) were independent predictors of MACEs in the 2.5 year follow-up period. Low apelin-12 also predicted poorer in-hospital prognosis and MACEs in the 2.5 years follow-up period compared with Δapelin-12 (P=0.0115) and eGFR (P=0.0071) among patients with eGFR>90 mL/min×1.73 m2. Further analysis showed Δapelin-12 <20% was associated with MACEs in patients whose apelin-12 was below 0.76 ng/mL (P=0.0075) on admission.ConclusionsPatients with STEMI receiving pPCI with lower apelin-12 are more likely to suffer MACEs in hospital and 2.5 years postprocedure, particularly in those with normal eGFR levels.

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“…It has been reported that the plasma concentration of apelin-12 after acute myocardial infarction (AMI) is significantly lower than that in the control population [ 15 , 16 ]. Apelin-12 is negatively associated with troponin I levels, high-sensitivity C-reactive protein, neutrophil/lymphocyte ratio, and the rate of MACE, indicating that apelin-12 can serve as a prognostic biomarker for STEMI patients [ 9 , 17 ]. This is consistent with the results of our study.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Combining Apelin-12 and Estimated Glomerular Filtration Rate in Patients with ST-Segment Elevation Myocardial Infarction

Liu

Xia

et al. 2022

Journal of Interventional Cardiology

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Background. Apelin-12 and estimated glomerular filtration rate (eGFR) are considered prognostic factors for ST-segment elevation myocardial infarction (STEMI). However, little is known about whether the combined use of these two biomarkers could enhance the prognostic value. This study aimed to investigate the utility of combining apelin-12 and eGFR for STEMI. Methods. Patients were divided into four groups based on median apelin-12 level and eGFR level: A: low apelin-12, low eGFR; B: low apelin-12, high eGFR; C: high apelin-12, low eGFR; and D: high apelin-12, high eGFR. The Cox regression was used to identify prognostic factors. The Kaplan–Meier and the receiver operating characteristic (ROC) curves were generated to evaluate the prognostic value of apelin-12 combined with eGFR in patients with STEMI. Results. Among 460 patients, 118 (25.7%) experienced major adverse cardiac events (MACEs) during the entire follow-up of 30 months. The Kaplan–Meier curve analysis revealed that group D had the best prognosis compared with the other three groups. The combination of apelin-12 and eGFR (area under the ROC curve (AUC), 0.699) enhanced the predictive value for MACE compared with either apelin-12 (AUC, 0.617) or eGFR (AUC, 0.596) alone. There was a negative association between apelin-12 and eGFR (r = −0.32, p < 0.001 ), while no association was observed between the Gensini score and apelin-12 or eGFR. Conclusions. This study suggests that both low apelin-12 (<0.76 ng/ml) and low eGFR (<94.06 mL/min/1.73 m2) are associated with poor prognosis in STEMI, indicating that the combination of apelin-12 and eGFR could enhance the prognostic value of patients with STEMI.

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Plasma apelin-12 levels may predict in-hospital major adverse cardiac events in ST-elevation myocardial infarction and the relationship between apelin-12 and the neutrophil/lymphocyte ratio in patients undergoing primary coronary intervention

Abstract: We have shown that lower apelin-12 level on admission is associated with higher SYNTAX scores and no-reflow phenomenon and may be used as a prognostic marker for hospital MACE in patients with STEMI.

Cited by 6 publications

References 29 publications

Prognostic Value of Circulating Inflammatory Cells in Patients with Stable and Acute Coronary Artery Disease

Prognostic Value of Circulating Inflammatory Cells in Patients with Stable and Acute Coronary Artery Disease

Predictive value of apelin-12 in patients with ST-elevation myocardial infarction with different renal function: a prospective observational study

Prognostic Value of Combining Apelin-12 and Estimated Glomerular Filtration Rate in Patients with ST-Segment Elevation Myocardial Infarction

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