Plasma and urinary vascular endothelial growth factor and diabetic nephropathy in Type 2 diabetes mellitus

Kim, N. H.; Kim, K. B.; Kim, D. L.; Kim, S. G.; Choi, Kyung Mook; Baik, Sei Hyun; Choi, Dong Seop; Kang, Young Sun; Han, Sang Youb; Han, Kum Hyun; Yi, Ji; R., D.

doi:10.1111/j.1464-5491.2004.01200.x

Cited by 57 publications

(53 citation statements)

References 29 publications

(22 reference statements)

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“…It was reported that overproduction of VEGF can act as a link between MAU and cardiovascular risk, which not only increases vascular permeability, promoting haemorrhagic and atherosclerotic processes, but also increases the permeability of the glomerular filter for albumin [14]. Several authors have shown that serum VEGF depends on the degree of obesity [15]; our studies have also revealed this pattern.…”

Section: Fundingsupporting

confidence: 68%

Interrelation of Adipokines with Functional State of Kidneys in Patients with Metabolic Syndrome

Shulkina¹,

Смирнова²,

Trushin³

2016

Biol Med (Aligarh)

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The aim of this study was to evaluate the effect of adipokines on the formation of kidney disease in patients with obesity and hypertension. The survey included 87 patients with hypertension (stage 1-2): with obesity (n 5 67), without obesity (n 5 20). In control group, there were 25 obese patients without hypertension and metabolic changes and 30 healthy persons (mean age 48.2 6 2.4 years). We investigated the relationship between leptin, resistin, and integral indices of renal damage (glomerular filtration rate [GFR], microalbuminuria [MAU], vascular endothelial growth factor [VEGF]). In obese patients without clinical signs of renal disease, a decrease in GFR was detected in 44.7% of respondents. Levels of leptin and resistin, markers of renal damage (MAU, VEGF), were significantly higher in the group of obesity. Correlation analysis showed the existence of a high degree of direct connection between the level of adipokines and HOMA index, triglycerides (TG), MAU, VEGF in the urine, and a negative correlation with GFR. There was a direct positive relationship between the level of MAU and VEGF in the urine with levels of blood pressure, uric acid, and a negative one with GFR. Levels of MAU and VEGF in urine can be considered as early markers of renal dysfunction in obese patients. The decrease in GFR in patients with obesity was associated with increased levels of leptin and resistin. So, in patients with MS and hypertension, reduction of GFR is linked with the increase in leptin and resistin that is accompanied with the increase of VEGF in urine and MAU. In non-obese patients with hypertension obesity and MS, the increase of VEGF in urine is detected ealier that increase of MAU and reduction of GFR. B io lo g y and M e d ic in e

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Section: Fundingsupporting

confidence: 68%

Interrelation of Adipokines with Functional State of Kidneys in Patients with Metabolic Syndrome

Shulkina¹,

Смирнова²,

Trushin³

2016

Biol Med (Aligarh)

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“…131,132 Since podocyte dysfunction occurs in diabetes mellitus and DN is actually considered a podocytopathy, nephrinuria has been reported in some T1DM patients before the onset of microalbuminuria, 133 as well as in some normoalbuminuric T2DM patients. 134 Furthermore, another podocyte biomarker like urinary VEGF has been found to be increased in T2DM patients with microalbuminuria and macroalbuminuria, 135 while higher levels of podocalyxin were seen in diabetic patients with microalbuminuria than in diabetic patients with normoalbuminuria. 136 Finally, some authors have reported that high values of urinary AGEs were seen in 50% of the T2DM patients with normoalbuminuria and in 85% of those with microalbuminuria.…”

Section: Miscellaneous Biomarkersmentioning

confidence: 99%

The role of novel biomarkers in predicting diabetic nephropathy: a review

Uwaezuoke

2017

IJNRD

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Diabetic nephropathy (DN) is one of the microvascular complications of the kidney arising commonly from type 1 diabetes mellitus (T1DM), and occasionally from type 2 diabetes mellitus (T2DM). Microalbuminuria serves as an early indicator of DN risk and a predictor of its progression as well as cardiovascular disease risk in both T1DM and T2DM. Although microalbuminuria remains the gold standard for early detection of DN, it is not a sufficiently accurate predictor of DN risk due to some limitations. Thus, there is a paradigm shift to novel biomarkers which would help to predict DN risk early enough and possibly prevent the occurrence of end-stage kidney disease. These new biomarkers have been broadly classified into glomerular biomarkers, tubular biomarkers, biomarkers of inflammation, biomarkers of oxidative stress, and miscellaneous biomarkers which also include podocyte biomarkers, some of which are also considered as tubular and glomerular biomarkers. Although they are potentially useful for the evaluation of DN, current data still preclude the routine clinical use of majority of them. However, their validation using high-quality and large longitudinal studies is of paramount importance, as well as the subsequent development of a biomarker panel which can reliably predict and evaluate this renal microvascular disease. This paper aims to review the predictive role of these biomarkers in the evaluation of DN.

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“…This diminishes the level of an antioxidant enzyme SOD, the first metallo protein enzyme, which is involved in the conversion of super oxide anion radical (O 2 -) to H 2 O 2 thereby removing the superoxide anions. Also the production of VEGF leads to the proteinuria thereby adding complications to DN [78,79]. On an overall perspective, it is found that under diabetic conditions, intracellular ROS is elevated due to many converging pathways and finally leads to nephropathic situation by activating an array of diverging signaling cascades (Figure 3).…”

Section: Oxidative Stress and Diabetic Nephropathymentioning

confidence: 99%

Therapeutic Insights against Oxidative Stress Induced Diabetic Nephropathy: A Review

Sadhukhan¹

2015

J Autoimmune Disord

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Plasma and urinary vascular endothelial growth factor and diabetic nephropathy in Type 2 diabetes mellitus

Abstract: Urinary excretion of VEGF increased during the earlier stage of diabetic nephropathy and was significantly correlated with urinary albumin excretion. This suggests that urinary VEGF might be used as a sensitive marker of diabetic nephropathy and for predicting disease progression.

Cited by 57 publications

References 29 publications

Interrelation of Adipokines with Functional State of Kidneys in Patients with Metabolic Syndrome

Interrelation of Adipokines with Functional State of Kidneys in Patients with Metabolic Syndrome

The role of novel biomarkers in predicting diabetic nephropathy: a review

Therapeutic Insights against Oxidative Stress Induced Diabetic Nephropathy: A Review

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