Therapeutic Insights against Oxidative Stress Induced Diabetic Nephropathy: A Review

Sadhukhan, Pritam

doi:10.21767/2471-8153.100002

Cited by 13 publications

(12 citation statements)

References 171 publications

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“…Literature suggests that, at very low concentration mangiferin exhibits antiproliferative activity on leukemic cells by inducing apoptosis. Mangiferin is again found to induce cell death by suppressing the activity of the molecule NF-jB [22], suggesting that this polyphenolic compound can elicit different signaling cascades and thus can be considered as a therapeutic option to bypass the side effects of the conventional drugs [23,24]. Reports also confirm its protective role against various cancers.…”

Section: Introductionmentioning

confidence: 99%

Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential

2016

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Over the last era, small molecules sourced from different plants have gained attention for their varied and long-term medicinal benefits. Their advantageous therapeutic effects in diverse pathological complications lead researchers to give an ever-increasing emphasis on them and discover their novel therapeutic potentials. Among these, the heat stable, xanthonoid group of organic molecules has gained special importance with distinctive regards to the bioactive molecule mangiferin due to its solubility in water. Mangiferin, a yellow polyphenol having C-glycosyl xanthone structure, is widely present in different edible sources like mango, and possesses numerous biological activities. Extensive research with this molecule shows its antioxidant, anti-inflammatory, antidiabetic, anticancer, antimicrobial, analgesic, and immunomodulatory properties. Thus, it provides protection against a wide range of physiological disorders. The C-glucosyl linkage and polyhydroxy groups in mangiferin's structure contribute essentially to its free radical-scavenging activity. Moreover, its ability in regulating various transcription factors like NF-κB, Nrf-2, etc. and modulating the expression of different proinflammatory signaling intermediates like tumor necrosis factor-α, COX-2, etc. contribute to its anti-inflammatory, anticancer, and antidiabetic potentials. In this comprehensive article, information has been provided about the sources, chemical structure, metabolism, and different biological activities of mangiferin with special emphasis on the underlying cellular signal transduction pathways. Insights into an in-depth assessment of mangiferin's anti-inflammatory therapeutic potential have also been discussed in detail. On an overall perspective, this review aims to stage mangiferin's diversified therapeutic applications and its emerging possibility as a promising drug in future based on its anti-inflammatory property. © 2016 BioFactors, 42(5):459-474, 2016.

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Section: Introductionmentioning

confidence: 99%

Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential

2016

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“…But reports are there suggesting that endoplasmic reticulum stress plays another crucial role in the pathophysiological conditions associated with acute and chronic As trioxide intoxication. Interestingly, some researchers suggest the decreased risk of hepatic toxicity and diseases is closely associated with the consumption of increased plant products, mainly due to the intake of specific phytochemicals present in them . So, treating As‐intoxicated liver with the help of the phytomolecule mangiferin, known for its numerous medicinal properties, such as antioxidant, anti‐inflammatory and so forth, seems to be a logical and novel approach.…”

Section: Discussionmentioning

confidence: 99%

Attenuative role of mangiferin in oxidative stress‐mediated liver dysfunction in arsenic‐intoxicated murines

et al. 2016

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Mangiferin (MAG), a natural xanthone mainly derived from mangoes, possesses great antioxidative potentials. The present study has been carried out to investigate the hepato-protective role of MAG, against arsenic (As)-induced oxidative damages in the murine liver. As, a well-known toxic metalloid, is ubiquitously found in nature and has been reported to affect nearly all the organs of the human body via oxidative impairment. Administration of As in the form of sodium arsenite (NaAsO ) at a dose of 10 mg/kg body weight for 3 months abruptly increased reactive oxygen species (ROS) level, led to oxidative stress and significantly depleted the first line of antioxidant defense system in the body. Moreover, As caused apoptosis in hepatocytes. Treatment with MAG at a dose of 40 mg/kg for body weight for 30 days simultaneously and separately after NaAsO administration decreased the ROS production and attenuated the alterations in the activities of all antioxidant indices. MAG also protected liver against the NaAsO -induced apoptosis and disintegrated hepatocytes, thus counteracting with As-induced toxicity. It could significantly inhibit the expression of different proapoptotic caspases and upregulate the expression of survival molecules such as Akt and Nrf2. On inhibiting Akt (by PI3K inhibitor, LY294002) and ERK1/2 (by ERK1/2 inhibitor, PD98059) specifically, caspase 3 got activated abolishing mangiferin's protective role on As-induced hepatotoxicity. So here, we have briefly elucidated the signaling cascades involved in As-induced apoptotic cell death in the liver and also the detailed cellular mechanism by which MAG provides protection to this organ. © 2016 BioFactors, 42(5):515-532, 2016.

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“…Under normal physiological conditions, low exposure to these xenobiotics or toxic substances, certain physiological processes get activated endogenously, and the cell can counteract the negative consequences of those toxic substances [13] , [14] . However, excessive exposure to pollutants may lead to several diseases including diabetes, asthma, chronic obstructive pulmonary disorder (COPD), neurodegenerative disorders, cancer, etc [15] , [16] , [17] , [18] , [19] . Every type of mammalian cells held a diverse and synchronized defense mechanism to decontaminate the intracellular environment and retain normal physiological conditions [20] , [21] .…”

Section: Introductionmentioning

confidence: 99%

Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy

et al. 2017

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The Nuclear factor erythroid2-related factor2 (Nrf2), a master regulator of redox homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant and detoxification enzymes. It protects organs from various kinds of toxic insults. On the other hand, activation of Nrf2 is also correlated with cancer progression and chemoresistance. Downregulation of Nrf2 activity has attracted an increasing amount of attention as it may provide an alternative cancer therapy. In this review, we examine recent studies on roles of Nrf2 in several pathophysiological conditions emphasising cancer. We discuss elaborately the current knowledge on Nrf2 regulation including KEAP1-dependent and KEAP1-independent cascades. KEAP1/Nrf2 system is a master regulator of cellular response against a variety of environmental stresses. We also highlight several tightly controlled regulations of Nrf2 by numerous proteins, small molecules, toxic metals, etc. In addition, we evaluate the possible therapeutic approaches of increasing chemosensitivity via modulating Nrf2 signaling.

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Therapeutic Insights against Oxidative Stress Induced Diabetic Nephropathy: A Review

Cited by 13 publications

References 171 publications

Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential

Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential

Attenuative role of mangiferin in oxidative stress‐mediated liver dysfunction in arsenic‐intoxicated murines

Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy

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