Plasma and Urinary Serotonin and 5-Hydroxyindol-3-Acetic Acid in Adults with Migraine and Tension-Type Headache

Milovanović, D. D.; Majkić-Sing, N.; Mirković, Darko; Pavlović, Jelena

doi:10.1007/978-1-4615-4709-9_25

Cited by 12 publications

(13 citation statements)

References 11 publications

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“…The observed decrease in 5-HT and 5-HIAA was not found to be correlated with age, sex, or duration of headache. These results coincide with those obtained by Milovanovic et al [6] who found that the urinary and plasma levels of 5-HT and 5-HIAA were significantly decreased in migraine as well as in tension type headache patients with more significant decrease in the catabolism of 5-HT during the attacks of either migraine or tension type headache as evidenced by the significantly reduced urinary values of 5-HIAA. The involvement of serotonin in migraine and tension type headache was not related to the presence of aura.…”

Section: Discussionsupporting

confidence: 92%

Serotonin and Its Metabolite; 5-Hydroxyindoleacetic Acid in Neurophysiology of Headache

Fouad

Rashed

et al. 2003

J. Clin. Biochem. Nutr.

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Although some trace amines have clearly defined roles as neurotransmitters in human, their exact role in the neurophysiology of headache remains unclear. In this study, plasma levels of one trace biogenic amine; serotonin (5-HT) and its metabolite; 5-hydroxyindoleacetic acid (5-HIAA) were assayed by high performance liquid chromatography with electrochemical detection in 50 subjects suffering from chronic headache due to various aetiologies including migraine. Moreover, 30 normal healthy subjects were also included in the study as control group. Results of the present work demonstrated significant decrease in plasma levels of both 5-HT and 5-HIAA in patients with chronic headache as compared with control subjects. Furthermore, 5-HT and 5-HIAA levels were not found to be conelated with the duration of headache, age and sex of the patient groups studied. Moreover, the two parameters exhibited significant decrease in subjects with migraine as compared with subjects with chronic headache due to causes other than migraine. This finding points to the major role played by 5-HT deficiency in the pathophysiology of headache in general and migraine in particular. The identifications of the exact pathophysiology of headache and migraine lead to the development of novel therapeutics for subjects with migraine as well as non migranous chronic headache.

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Section: Discussionsupporting

confidence: 92%

Serotonin and Its Metabolite; 5-Hydroxyindoleacetic Acid in Neurophysiology of Headache

Fouad

Rashed

et al. 2003

J. Clin. Biochem. Nutr.

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“…Serotonin is critically important in the pathogenesis of both migraine and tension-type headache, with peripheral serotonin levels dropping similarly during headache attacks for both migraine and tension-type headache [28,29]. Currently accepted models of chronic headache postulate that reductions in peripheral serotonin trigger a headache response.…”

Section: Estrogen and Tension-type Headachementioning

confidence: 99%

Estrogen and tension-type headache

Marcus

2001

Current Science Inc

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The vast majority of people experience tension-type headache during their lifetimes. Boys experience tension-type headache slightly more than girls during preadolescent years. During adolescence and adult years, tension-type headache occurs more commonly in females. Tension-type headache changes in women occur in relation to gynecologic changes, including menses, pregnancy, and menopause. These changes are related to estrogen fluctuations. Estrogen fluctuations cause changes in neurochemicals important for pain signal transmission, including serotonin, gamma-aminobutyric acid, and enkephalins.

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“…52 Some studies found that the increased excretion of 5-HIAA, which is the main metabolite of 5-HT, through urine is associated with migraine attacks. 52,53 Two other studies 54 Previous studies also examined the 5-HT level in migraine patients and found a low-5-HT level. 44,56 The deficiency or depletion of tryptophan, a precursor to serotonin synthesis, can lead to increased symptoms of depression and migraine.…”

Section: Neurotr An S Mit Ter S and Recep To R Smentioning

confidence: 98%

The exploration of mechanisms of comorbidity between migraine and depression

Zhang

Shao

Jiang

et al. 2019

J Cellular Molecular Medi

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Migraine comorbid with depression is common and is often encountered in clinical practice. The comorbidity may lead to more serious conditions with other symptoms and a longer duration of treatment and it may impose heavy economic and social burdens, directly or indirectly, on patients and their families. Numerous studies have been published on the association of migraine with depression. Numerous literature have showed that the comorbidity may have a common complicated pathogenic mechanism involving biopsychosocial characteristics, including abnormal brain development and shared genetic basis, as well as neurotransmitters, sex hormones and stress. In addition, some studies have identified the multiple, bidirectional relationship between migraine and depressive disorder. We searched the literature for the possible common mechanisms between migraine and depression and classified the research results.

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Plasma and Urinary Serotonin and 5-Hydroxyindol-3-Acetic Acid in Adults with Migraine and Tension-Type Headache

Cited by 12 publications

References 11 publications

Serotonin and Its Metabolite; 5-Hydroxyindoleacetic Acid in Neurophysiology of Headache

Serotonin and Its Metabolite; 5-Hydroxyindoleacetic Acid in Neurophysiology of Headache

Estrogen and tension-type headache

The exploration of mechanisms of comorbidity between migraine and depression

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