The exploration of mechanisms of comorbidity between migraine and depression

Zhang, Qing; Shao, Anwen; Jiang, Zhengyan; Tsai, Huitzong; Liu, Weibo

doi:10.1111/jcmm.14390

Cited by 68 publications

(79 citation statements)

References 91 publications

(294 reference statements)

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“…The relationship between cerebral cortex thickness and cerebral activity needs further exploration to understand the co-pathogenic relationship between patients' cerebral function who was having depression with migraines [37][38]. The comorbid condition of depressive and migraine patients exhibits a marked decrease in the intrinsic brain activity in the thalamus [39]. Another study determined that some older people who do not have dementia but have a migraine and MDD had an overall reduced total brain volume as well as gray and white matter compared to patients who presented with either of the diseases [40].…”

Section: Morphological Changes In Cerebral Cortex and Thalamusmentioning

confidence: 99%

Is There an Association Between Migraine and Major Depressive Disorder? A Narrative Review

Jahangir¹,

Adjepong²,

Al-Shami³

et al. 2020

Cureus

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Various studies on the association of migraine with depression are published. The comorbidity may upgrade health conditions up to a critical degree. Besides, the duration of symptoms and treatment may be prolonged. Moreover, these conditions can force substantial financial and social hardships on patients and their families. In this literature review, we intend to examine the evidence obtained on the possible associations between migraine and major depressive disorder (MDD). This review is focused on aminergic neurons. One of the variables associated with patients who experience both of these two diseases might have a history of assault. In migraine and MDD patients, genetic evidence, such as single nucleotide polymorphisms (SNP), was found to be one of the associations. Another theory concluded that actual headache diagnosed in patients who received no treatment manifests a history of anxiety, and later, the patients display severe somatic symptoms. In conclusion, there is a robust molecular genetic background, explaining the relationship between migraines and MDD. This correlated data renders a combination of both diagnoses as single separate entities. However, further studies are encouraged to point out the issue of treatment strategies.

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Section: Morphological Changes In Cerebral Cortex and Thalamusmentioning

confidence: 99%

Is There an Association Between Migraine and Major Depressive Disorder? A Narrative Review

Jahangir¹,

Adjepong²,

Al-Shami³

et al. 2020

Cureus

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“…Migraine is a widespread neurovascular disabling disorder affecting up to 15% of the worldwide population and is typically characterized by one-sided throbbing long-lasting moderate or severe pain [ 1 , 2 ]. Migraine is associated with multiple psychiatric comorbidities such as anxiety, depression and panic disorders [ 3 , 4 , 5 , 6 ]. Despite this clear association, the CNS neuronal centers underlying the link between migraine and the comorbid psychiatric conditions remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine

Pietra

Giniatullin

Savinainen

2021

IJMS

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In migraine pain, cannabis has a promising analgesic action, which, however, is associated with side psychotropic effects. To overcome these adverse effects of exogenous cannabinoids, we propose migraine pain relief via activation of the endogenous cannabinoid system (ECS) by inhibiting enzymes degrading endocannabinoids. To provide a functional platform for such purpose in the peripheral and central parts of the rat nociceptive system relevant to migraine, we measured by activity-based protein profiling (ABPP) the activity of the main endocannabinoid-hydrolases, monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH). We found that in trigeminal ganglia, the MAGL activity was nine-fold higher than that of FAAH. MAGL activity exceeded FAAH activity also in DRG, spinal cord and brainstem. However, activities of MAGL and FAAH were comparably high in the cerebellum and cerebral cortex implicated in migraine aura. MAGL and FAAH activities were identified and blocked by the selective and potent inhibitors JJKK-048/KML29 and JZP327A, respectively. The high MAGL activity in trigeminal ganglia implicated in the generation of nociceptive signals suggests this part of ECS as a priority target for blocking peripheral mechanisms of migraine pain. In the CNS, both MAGL and FAAH represent potential targets for attenuation of migraine-related enhanced cortical excitability and pain transmission.

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“… 4 Multiple studies have demonstrated that the comorbidity of migraine and depression is bi-directional 4 , 5 ; therefore, various shared etiologic mechanisms associated with depression and migraine have been proposed. 6 , 7 While no single possibility has provided sufficient clarification, a dysfunctional serotoninergic system could be an explanation. 7 – 9 …”

Section: Introductionmentioning

confidence: 99%

“… 6 , 7 While no single possibility has provided sufficient clarification, a dysfunctional serotoninergic system could be an explanation. 7 – 9 …”

Section: Introductionmentioning

confidence: 99%

Hypoechogenicity of the midbrain raphe detected by transcranial sonography: an imaging biomarker for depression in migraine patients

Zhang

Liu

Han

et al. 2021

Ther Adv Neurol Disord

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Background: The high comorbidity of migraine and depression is suggestive of shared risk factors or common mechanisms between the two diseases. In individuals with a depressive disorder, there is a high prevalence of altered midbrain raphe (MBR) echogenicity, detectable via transcranial sonography (TCS), that is suggested to be linked with a dysfunction of the serotoninergic system. In patients with migraine, this alteration has seldom been explored in earlier studies, and conclusions are often lacking. Our study aimed to elucidate whether this alteration is specific to migraine and to determine whether it is related with depression. Methods: This study enrolled patients with migraine ( n = 100, 72% female) and patients with tension-type headache disorders (TTH) ( n = 62, 78.5% female) from a headache clinic. In addition, 79 healthy subjects (79.7% female) were recruited as controls. All participants underwent a standard interview to evaluate headache information and an interview with psychiatrists for depression evaluation. TCS examinations were performed on all participants. Results: Patients with migraine had a higher rate of MBR hypoechogenicity (28%) compared with that of healthy controls (15.2%) and that of patients with TTH (12.9%). In patients with migraine, reduced MBR echogenicity was associated with depressive symptoms assessed using the Hamilton Depression Rating Scale (HAM-D). No association between migraine self-medication and MBR echogenicity was found. Conclusion: Reduced-echoic MBR detected by TCS is prevalent in migraine patients and is associated with depressive symptoms. TCS-detected hypoechogenic MBR abnormality could be an imaging biomarker of depressive symptoms in patients with migraine.

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The exploration of mechanisms of comorbidity between migraine and depression

Cited by 68 publications

References 91 publications

Is There an Association Between Migraine and Major Depressive Disorder? A Narrative Review

Is There an Association Between Migraine and Major Depressive Disorder? A Narrative Review

Distinct Activity of Endocannabinoid-Hydrolyzing Enzymes MAGL and FAAH in Key Regions of Peripheral and Central Nervous System Implicated in Migraine

Hypoechogenicity of the midbrain raphe detected by transcranial sonography: an imaging biomarker for depression in migraine patients

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