Plasma and peripheral blood mononuclear cells levels of Zn and Cu among Indian patients with RA

Wanchu, Ajay; Sud, Archana; Bambery, P; Prasad, Rupesh; Kumar, Vinod

doi:10.1136/ard.61.1.88

Cited by 14 publications

(5 citation statements)

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“…Juvenile Idiopathic Arthritis (JIA) is the most common chronic arthropathy in childhood which is a leading cause of short and long-term disability [17]. The importance of trace elements e.g., zinc and copper in chronic inflammatory arthritis is related to their role in different metabolic processes in articular tissues and in the functions of the immune system [9] [10].…”

Section: Discussionmentioning

confidence: 99%

Serum Zinc and Copper Level in Juvenile Idiopathic Arthritis (JIA) Patients and Its Correlation with Disease Duration-A Tertiary Hospital Study

Islam,

Haque,

Sultana

et al. 2024

OJRA

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Background: Juvenile Idiopathic Arthritis (JIA) is the most prevalent rheumatic disease in children. It is associated with abnormal levels of serum zinc (Zn) and copper (Cu) as during inflammation serum copper concentration increases and zinc decreases. Objective: To assess the serum Zn and Cu levels in different sub-types of JIA patients and their correlation with the disease duration. Methods: This cross-sectional study was conducted over twelve months at the Pediatric Rheumatology Division, Department of Paediatrics, Bangabandhu Sheikh Mujib Medical University. Sixty-nine JIA cases that fulfilled the International League of Association for Rheumatology (ILAR) criteria were taken as cases and age and sex-matched healthy children were considered as controls. The serum Zn and Cu tests were done using the spectrophotometric method with INDIKO PLUS Drug Analyzer. Data were recorded in a pre-designed questionnaire. Data were checked, verified and analyzed manually where continuous variables were analyzed using unpaired t-test and categorical variables using the ANOVA test. Pearson's correlation coefficient test was used to see the correlation of serum zinc and copper levels with disease duration. Results: Boys were predominant in both case and control groups, with the majority within the 10 to 16-year-age group. Enthesitis-related arthritis (ERA) was the most common subtype followed by sJIA, Oligo JIA, Poly JIA (RF-) and unclassified subtypes. Disease duration was found less than 12 months in 30.4% of JIA patients. Serum analysis revealed a statistically significant reduction in mean zinc levels and increased copper levels in JIA patients compared to controls. This study observed a negative correlation between How to cite this paper

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Section: Discussionmentioning

confidence: 99%

Serum Zinc and Copper Level in Juvenile Idiopathic Arthritis (JIA) Patients and Its Correlation with Disease Duration-A Tertiary Hospital Study

Islam,

Haque,

Sultana

et al. 2024

OJRA

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“…3b). Decrease in Zn concentrations in nail and hair of rheumatoid arthritis patients in Group RA shows a redistribution of trace elements due to inflammatory character [83].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Minerals in Obesity-related Diseases in the Chandigarh (India) Population

Taneja

Mandal

2007

Biol Trace Elem Res

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Excessive Zn but normal Cu and Mg in the staple food consumed by the people of Chandigarh (Union territory and capital of Punjab and Haryana States of India) has been considered to be the major risk factor for the prevalence of obesity (33.15%) and obesity-related diseases in this region. Therefore, in the present investigations, in obesity-related diseases, the status of these minerals was estimated in their tissues, including hair, nails, and blood serum and urine, and compared with those of normal subjects. They were grouped as: normal subjects in control Group A, middle-aged diabetics in Group D(M), older diabetics in Group D(O), and diabetics with osteoarthritis in Group D+ OA, osteoarthritis in Group OA and rheumatoid arthritis in Group RA, respectively. The results evaluated in the order as: hair Zn, group D+OA>D(M)>OA>A (control)>RA>D(O) (p < 0.001); hair Cu, group A (control)>D(M)>OA>D+OA>D(O)>RA (p < 0.001); hair Mg, group A (control)>D(M)>OA>D+OA>RA>D(O) (p < 0.001, 0.01); hair Mn, group A (control)>RA>OA>D-OA>D(M)>D(O) (p < 0.001); nail Zn, group D(M)>D+OA>OA>A (control)>RA>D(O) (p < 0.001, 0.05); nail Cu, group A (control)>OA>D(M)>D+OA>RA>D(O) (p < 0.001); nail Mg, group A (control)>OA>D(M)>D(O)>D+OA >RA (p < 0.001); nail Mn, group A (control) >RA>OA>D+OA>D(M)>D(O) (p < 0.01); urine Zn, group D(O)>D(M)>D+OA>A (control)>RA>OA (p < 0.01); urine Cu, group RA>D+OA>D(O)>OA> D(M)>A (control) (p<0.001); urine Mg, group RA>OA>D+OA>D(O)>D(M)>A (control; p < 0.001); urine Mn, group D(O)>D(M)>OA>D+OA>RA>A (control; p < 0.001), respectively. The analysis of the mineral status in serum of diabetics further showed their highly significant rise from lower mean age subgroup to higher mean age subgroup than their control counter parts (p < 0.001, 0.01, and 0.05) with coincident deficiencies of Cu, Mg, and Mn in their tissues. This study would be helpful considering the status of minerals in these obesity-related diseases depending on the choice of the food consumed to improve the quality of life and prognosis for the diseases.

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“…In summary, exposure to heavy metals from sources other than vaccines, combined with genetic variants promoting immune dysfunction or impairing neurodevelopmental processes, could potentially exert small additive effects in a limited number of ASD children. However, it should be considered that the elevated blood levels of heavy metals found in many autoimmune disorders, such as rheumatoid arthritis [105], stem from active dysimmunity rather than from environmental contamination, and that similarly active dysimmunity may well be present in a consistent subset of ASD children, for which metal chelation therapy appears absolutely unjustified.…”

Section: Heavy Metalsmentioning

confidence: 99%

Environmental Factors in the Onset of Autism Spectrum Disorder

Persico

Merelli²

2014

Curr Dev Disord Rep

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Autism spectrum disorder (ASD) is a heterogeneous clinical condition whose prevalence has grown considerably during the last decade. Genetic factors are thought to underpin the disorder, but common genetic variants and epigenetic mechanisms have been increasingly called into question for the majority of ASD cases. Growing prenatal exposure to new environmental toxicants has been shown to potentially affect brain development, leading to altered cognitive, social, attentive, behavioral, and motor performance. Both epidemiological evidence and mechanistic studies assessing oxidative stress, neuroinflammation, epigenetic alterations, and impaired signal transduction, all observed following neurotoxicant exposure, indeed lend biological plausibility to Gene x Environment interactions, whereby environmental toxicants interacting additively or synergistically with genetic liability, can push prenatal neurodevelopmental processes over the threshold for postnatal ASD expression. Research on environmental contributions to ASD and on specific Gene x Environment interaction models ultimately aims at defining targeted preventive strategies.

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Plasma and peripheral blood mononuclear cells levels of Zn and Cu among Indian patients with RA

Abstract: Antiphospholipid antibodies and rheumatoid arthritis aCL, Anticardiolipin antibodies; β 2 GPI, β 2 glycoprotein I; NHS, normal human sera; RA, rheumatoid arthritis; RF, rheumatoid factor.

Cited by 14 publications

References 4 publications

Serum Zinc and Copper Level in Juvenile Idiopathic Arthritis (JIA) Patients and Its Correlation with Disease Duration-A Tertiary Hospital Study

Serum Zinc and Copper Level in Juvenile Idiopathic Arthritis (JIA) Patients and Its Correlation with Disease Duration-A Tertiary Hospital Study

Assessment of Minerals in Obesity-related Diseases in the Chandigarh (India) Population

Environmental Factors in the Onset of Autism Spectrum Disorder

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