Plasma and Dietary Carotenoids Are Associated with Reduced Oxidative Stress in Women Previously Treated for Breast Cancer

Thomson, Cynthia A.; Stendell-Hollis, Nicole R.; Rock, Cheryl L.; Cussler, Ellen; Flatt, Shirley W.; Pierce, John P.

doi:10.1158/1055-9965.epi-07-0350

Cited by 72 publications

(53 citation statements)

References 41 publications

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“…There is a very wide range of mean plasma lycopene levels, 0.07-1.79 lM [Mayne et al, 1999]. Lycopene consumption has been closely linked with the chemoprevention of a number of cancers, particularly prostate cancer [Ellinger et al, 2006]; and evidence for its utility in the breast cancer arena is emerging [Karas et al, 2000;Hirsch et al, 2007;Thomson et al, 2007]. Yet discrepancies remain in the literature pertaining the effectiveness of lycopene as a chemopreventive agent [Kavanaugh et al, 2007].…”

Section: Discussionmentioning

confidence: 99%

Modulation of gene methylation by genistein or lycopene in breast cancer cells

King-Batoon

Leszczyńska

Klein

2008

Environ and Mol Mutagen

209

113

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Dietary agents with chemopreventive potential, including soy-derived genistein and tomato-derived lycopene, have been shown to alter gene expression in ways that can either promote or potentially inhibit the carcinogenic processes. To begin to explore the mechanisms by which these agents may be acting we have examined the DNA methylation modulating capacity of genistein or lycopene for several genes relevant to breast cancer in the breast cancer cell lines MCF-7 and MDA-MB-468, as well as in immortalized but noncancer fibrocystic MCF10A breast cells. We find using methylation specific PCR (MSP) that a low, nontoxic concentration of genistein (3.125 lM, resupplemented every 48 hr for 1 week) or a single dose of lycopene (2 lM) partially demethylates the promoter of the GSTP1 tumor suppressor gene in MDA-MB-468 cells. RT-PCR studies confirm a lack of GSTP1 expression in untreated MDA-MB-468, with restoration of GSTP1 expression after genistein or lycopene treatment. The RARb2 gene however, was not demethylated by genistein or lycopene in either of these breast cancer cell lines. But, lycopene (2 lM, once per week for 2 weeks) did induce demethylation of RARb2 and the HIN-1 genes in the noncancer MCF10A fibrocystic breast cells. These data show for the first time that the tomato carotenoid lycopene has direct DNA demethylating activity. In summary, both genistein and lycopene, at very low, dietarily relevant concentrations can potentially mitigate tumorigenic processes via promoter methylation modulation of gene expression. Environ. Mol. Mutagen. 49:36-45, 2008.

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Section: Discussionmentioning

confidence: 99%

Modulation of gene methylation by genistein or lycopene in breast cancer cells

King-Batoon

Leszczyńska

Klein

2008

Environ and Mol Mutagen

209

113

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“…However, oxidation of biomolecules can be inhibited by suitable amounts of antioxidants present in balanced daily diet (Bose;Agrawal, 2007;Thomson et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Total carotenoids and antioxidant activity of fillets and shells (in natura or cooked) of “Vila Franca” shrimp (Litopenaeus Schmitti) in different intervals of storage under freezing

et al. 2017

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Shrimps are sources of carotenoids, astaxanthin is the predominant, responsible for their special and desirable properties, as well as for their instability under heat treatment during the domestic preparation, industrial processing or storage under freezing. These can cause discoloration and reduce the beneficial health properties. This study aimed to evaluate the effect of heat treatment and storage under freezing (0, 45 and 90 days) on the levels of total carotenoids and stability of the antioxidant activity of ethanolic extracts of fillets and shells, raw and cooked, of the white shrimp ("Vila Franca") Litopenaeus schmitti (Burkenroad, 1938). The antioxidant ability of the extracts was evaluated using the radicals DPPH• (2,2-diphenyl-1-picryl-hydrazyl) and ABTS + • (2,2'-azino-bis (3-ethylbenzothiazoline-6 sulfonic acid), as well as by the iron reducing power (FRAP) test. The extracts of cooked or in natura shrimps (fillets and shells) represent dietary sources of carotenoids, displaying antioxidant activity through all the tested methods, after heat treatment and storage under freezing. The antioxidant activity of the extracts was superior to the one of ascorbic acid, mainly in the cooked fillet and shells. The samples of shrimp shells seemed a valuable source of carotenoids, whose antioxidant activity was verified even 90 days after freezing, and can be used in food products as functional natural supplement, adding value to this waste.Index terms: Free radicals; functional food; biomolecules oxidation. RESUMOOs camarões são fontes de carotenóides, sendo a astaxantina o predominante, responsáveis por suas propriedades especiais e desejáveis, e também a causa da sua instabilidade pelo tratamento térmico durante o preparo doméstico, processamento industrial ou armazenamento sob congelamento, que pode causar descoloração e redução de suas propriedades benéficas à saúde. Este trabalho visou avaliar o efeito do tratamento térmico e armazenamento sob congelamento (0, 45 e 90 dias) nos teores de carotenóides totais e na estabilidade da atividade antioxidante dos extratos etanólicos de filé e cascas, cruas ou cozidas, de camarão "Vila Franca" Litopenaeus schmitti (Burkenroad, 1938). A capacidade antioxidante dos extratos foi avaliada utilizando os radicais DPPH• (2,2-difenil-1-picril-hidrazila) e ABTS + • (2,2'-azino-bis-(3-etilbenzotiazolina-6-acido sulfônico), bem como pelo teste do poder redutor do ferro (FRAP). Os extratos do camarão cozido ou in natura (filé e cascas), representam fontes dietéticas de carotenóides, exibindo atividade antioxidante através de todos os métodos testados, após o tratamento térmico e armazenamento sob congelamento. A atividade antioxidante dos extratos foi superior a de ácido ascórbico, principalmente no filé e cascas cozidos. As amostras de cascas de camarão parecem uma valiosa fonte de carotenóides, cuja atividade antioxidante foi verificada até 90 dias após o congelamento, e pode ser utilizado nos produtos alimentares como suplemento natural funcional, agregando valor a e...

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“…The beneficial effect of this antioxidant has been documented during various cancers of breast, lung, prostate, colon and also in leukemia (Karas et al, 2000;Sharoni et al, 2004). In a recent study, the occurrence of oxidative stress in breast cancer survivor with high dietary and plasma carotenoids was much lower than those with low dietary and plasma carotenoid (Thomson et al, 2008). This study indicates important role of carotenoids in oxidative stress mitigation.…”

Section: Carotenoidsmentioning

confidence: 65%