Plasma and Blood Volume Changes in Pregnancies Complicated by Pre‐eclampsia

Cope, Ian

doi:10.1111/j.1471-0528.1961.tb02746.x

Cited by 23 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this connexion, it is noteworthy that plasma volume is often reduced in certain conditions (experimental sodium deprivation, un-PLASMA RENIN AFTER HAEMORRHAGE treated Addison's disease, and hepatic cirrhosis with ascites) in which plasma-renin concentration is increased (Brown, Davies, Lever & Robertson, 1964c). However, in 'specific hypertensive disease of pregnancy' (Pickering, 1955) the plasma-renin concentration is not greater than the level found in normal pregnancy (Brown, Davies, Doak, Lever & Robertson, 1965) although plasma volume is reduced (Cope, 1961;MacGillivray, 1961).…”

Section: Discussionmentioning

confidence: 99%

The effect of acute haemorrhage in the dog and man on plasma‐renin concentration

Brown¹,

Davies²,

Lever³

et al. 1966

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of acute haemorrhage in the dog and man on plasma‐renin concentration

Brown¹,

Davies²,

Lever³

et al. 1966

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…However, the etiology of hypertension in preeclampsia remains unclear. In normal human pregnancy, there is increased cardiac output with expanded circulatory volume along with a decrease in peripheral vascular resistance (Figure 1) [5, 6]. During normal human gestation, blood pressure is slightly decreased (with minimal changes in systolic pressure but with evident diastolic blood pressure drop) because of the dilation of maternal vessels (Figure 1) [6].…”

Section: Basic Pathology and Physiology Of Preeclampsiamentioning

confidence: 99%

“…Such vessel dilation allows for fluid expansion in the mother and helps protect against placental hypoperfusion (Figure 1) [7]. However, in preeclamptic pregnancy, plasma volume is significantly decreased despite the presence of massive edema [5]. As a result, there is reduced systemic perfusion, which can lead to potential damage to the maternal organs and to the baby [8] (Figure 1).…”

Section: Basic Pathology and Physiology Of Preeclampsiamentioning

confidence: 99%

The biology of preeclampsia

Kanasaki

Kalluri

2009

Kidney International

143

109

View full text Add to dashboard Cite

Preeclampsia is a systemic disease that results from placental defects and occurs in about 5–8% of pregnancies worldwide. Preeclampsia is a disease of many theories, wherein investigators put forward their favorite mechanistic ideas, each with a causal appeal for the pathogenesis of preeclampsia. In reality, the patho-mechanism of preeclampsia remains largely unknown. Preeclampsia, as diagnosed in patients today, is likely a heterogeneous collection of disease entities that share some common features but also exhibit important differences. Therefore, one single mechanism may never be found to explain all the variants of preeclampsia. Current research must focus on evaluating such diverse mechanisms, as well as the possible common effectors pathways. Here we provide a discussion of several possible mechanisms and putative theories proposed for preeclampsia, with particular emphasis on the recent discovery of a new genetic mouse model offering new opportunities to explore experimental therapies.

show abstract

“…In mild toxaemia, there was no difference as compared with normal pregnancy, but in severe toxaemia and in eclampsia the plasma volume was decreased. Cope (1961) also found reduced plasma volume in toxaemic pregnancies, and suggested that this was due to peripheral vasospasm. Hytten and Leitch (1964), reviewing the evidence for an increase in plasma volume in pregnancy, concluded that in healdiy women in a normal first pregnancy the value increased from a non-pregnant level of about 2,600 ml by an average of 1,250 ml.…”

Section: Discussionmentioning

confidence: 89%

Serum Cholinesterase Deficiency Ii: Pregnancy

Robertson¹

1966

British Journal of Anaesthesia

View full text Add to dashboard Cite

The conflicting evidence regarding changes in serum cholinesterase during pregnancy is briefly reviewed. A technique for the estimation of serum cholinesterase by continuous titration at constant pH is described, and the results of a study of the enzyme in 149 pregnant women are presented. Pregnant women had a diminution of serum cholinesterase activity compared with non-pregnant women of the child-bearing age group, and this diminution is statistically highly significant. The fall appeared to begin soon after 10 weeks gestation. The reduction of enzyme activity in patients with toxaemia of pregnancy was not significantly different from that in non-toxaemic cases. Reasons are presented for believing that neither haemodilution nor hepatic insufficiency can provide an adequate explanation for the changes described. The possible clinical importance of the changes is outlined.

show abstract

Plasma and Blood Volume Changes in Pregnancies Complicated by Pre‐eclampsia

Cited by 23 publications

References 12 publications

The effect of acute haemorrhage in the dog and man on plasma‐renin concentration

The effect of acute haemorrhage in the dog and man on plasma‐renin concentration

The biology of preeclampsia

Serum Cholinesterase Deficiency Ii: Pregnancy

Contact Info

Product

Resources

About