Plasma Adropin Levels Predict Endothelial Dysfunction Like Flow-Mediated Dilatation in Patients With Type 2 Diabetes Mellitus

Topuz, Mustafa; Çelik, Ahmet; Aslantas, Tutku; Demir, Ayşe Kevser; Aydın, Suna

doi:10.2310/jim.0000000000000003

Cited by 102 publications

(33 citation statements)

References 34 publications

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“…Several studies investigated a relationship between adropin level and cardiovascular complications in humans. Potential contribution of adropin to function of endothelial cells was reported by Topus et al [23]. This study reported that endothelial dysfunctions in patients with type 2 diabetes is paralleled by low levels of circulating adropin [23].…”

Section: Adropin In the Cardiovascular Systemmentioning

confidence: 67%

“…Potential contribution of adropin to function of endothelial cells was reported by Topus et al [23]. This study reported that endothelial dysfunctions in patients with type 2 diabetes is paralleled by low levels of circulating adropin [23]. An association between low levels of adropin and cardiovascular disorders was also reported.…”

Section: Adropin In the Cardiovascular Systemmentioning

confidence: 67%

“…Serum levels of adropin are lower in type 2 diabetic patients as compared to healthy controls [22]. In addition, low levels of adropin in type 2 diabetes mellitus are a risk factor for endothelial dysfunction [23]. Downregulation of adropin in circulation in type 2 diabetes was also reported by Chen et al [24].…”

Section: Modulation Of Adropin By Body Mass Index (Bmi) Diet and DImentioning

confidence: 77%

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Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

et al. 2020

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Adropin is a unique hormone encoded by the energy homeostasis-associated (Enho) gene. Adropin is produced in the liver and brain, and also in peripheral tissues such as in the heart and gastrointestinal tract. Furthermore, adropin is present in the circulatory system. A decade after its discovery, there is evidence that adropin may contribute to body weight regulation, glucose and lipid homeostasis, and cardiovascular system functions. In this review, we summarize and discuss the physiological, metabolic, and pathophysiological factors regulating Enho as well as adropin. Furthermore, we review the literature addressing the role of adropin in adiposity and type 2 diabetes. Finally, we elaborate on the role of adropin in the context of the cardiovascular system, liver diseases, and cancer.

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Section: Adropin In the Cardiovascular Systemmentioning

confidence: 67%

Section: Adropin In the Cardiovascular Systemmentioning

confidence: 67%

Section: Modulation Of Adropin By Body Mass Index (Bmi) Diet and DImentioning

confidence: 77%

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Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

et al. 2020

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“…This result suggests that the change in the serum adropin concentration may be one mechanism by which the exercise intervention improved vascular endothelial function in obese adolescents. Previous studies also demonstrated that a lower serum adropin level was associated with endothelial dysfunction using flow-mediated dilatation in patients with type-2 diabetes mellitus and metabolic syndrome 36 , 37 . Aerobic exercise training increased the serum adropin level and improved arterial stiffness and adiposity in obese adults 38 .…”

Section: Discussionmentioning

confidence: 83%

Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss

Zhang

Jiang

Yang

et al. 2017

Sci Rep

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Adropin is a secreted protein that regulates endothelial function. However, adropin levels in obese adolescent patients are currently uncertain. Therefore, we evaluated the association between plasma adropin levels and vascular endothelial function and investigated the effect of aerobic exercise in obese adolescents. A total of 45 obese adolescents and 20 controls (age 16–19 years) were included in our study. The obese adolescents received 12 weeks of aerobic exercise training. Serum adropin was detected using enzyme-linked immunosorbent assay. Vascular reactive hyperemia indexes (RHIs) were obtained using Endo-PAT2000. Adropin levels and RHI were significantly lower in obese adolescents than in normal-weight adolescents. Adropin levels and RHI increased significantly independently of changes in body weight after an exercise intervention (P < 0.01). Pearson correlation analysis revealed that adropin levels positively correlated with HDL-C levels (r = 0.389, P < 0.01) and RHI (r = 0.32, P < 0.01). Multiple linear stepwise regression analysis showed that the insulin resistance index (t = −3.301, P < 0.01) and HDL-C level (t = 2.620, P = 0.011) were independent risk factors of adropin levels. In addition, Δadropin (t = 3.261, P < 0.01) was an independent influencing factor of ΔRHI. Our findings suggest that adropin plays an important role in vascular endothelial function in obese adolescents.

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“…As previously reported (Jones et al, 1981a,b; Yang F. et al, 2016), our data also showed that water consumption in the 3700 m hypoxia group decreased > 40% at 1 day after 12 h water restriction as compared to the normoxia group, and the inhibition effect continued for at least 3 days (Figure 1E). We also tested adropin, which functions as a vascular protective factor in Type 2 diabetes patients and an inhibitor in the brain center of water drinking through an orphan G protein-coupled receptor 19 (GPR19; Topuz et al, 2013; Hu and Chen, 2016; Stein et al, 2016). Interestingly, our results showed that serum adropin was elevated under 3700 m hypoxia, and further increased in the 6000 m hypoxia group as compared to the moderate group (Figure 1D).…”

Section: Resultsmentioning

confidence: 99%

Adropin Is a Key Mediator of Hypoxia Induced Anti-Dipsogenic Effects via TRPV4-CamKK-AMPK Signaling in the Circumventricular Organs of Rats

Yang

Zhou

et al. 2017

Front. Mol. Neurosci.

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Water intake reduction (anti-dipsogenic effects) under hypoxia has been well established, but the underlying reason remains unknown. Our previous report indicated that activated TRPV4 neurons in SFO are associated with anti-dipsogenic effects under hypoxia. Although low partial pressure of blood oxygen directly activates TRPV4, humoral factors could also be involved. In the present study, we hypothesize that adropin, a new endogenous peptide hormone, was rapidly increased (serum and brain) concomitant with reduced water intake in early hypoxia. Also, the nuclear expression of c-Fos, a marker for neuronal activation, related to water-consumption (SFO and MnPO) was inhibited. These effects were mitigated by a scavenger, rat adropin neutralizing antibody, which effectively neutralized adropin under hypoxia. Interestingly, injection of recombinant adropin in the third ventricle of the rats also triggered anti-dipsogenic effects and reduced c-Fos positive cells in SFO, but these effects were absent when TRPV4 was knocked down by shRNA. Moreover, adropin-activated CamKK-AMPK signaling related to TRPV4 calcium channel in SFO in normoxia. These results revealed that dissociative adropin was elevated in acute hypoxia, which was responsible for anti-dipsogenic effects by altering TRPV4-CamKK-AMPK signaling in SFO.

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Plasma Adropin Levels Predict Endothelial Dysfunction Like Flow-Mediated Dilatation in Patients With Type 2 Diabetes Mellitus

Abstract: Adropin is a new marker for use in demonstrating endothelial dysfunction.

Cited by 102 publications

References 34 publications

Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss

Adropin Is a Key Mediator of Hypoxia Induced Anti-Dipsogenic Effects via TRPV4-CamKK-AMPK Signaling in the Circumventricular Organs of Rats

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