Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss

Zhang, Hao; Jiang, Long; Yang, Yujing; Ge, Renkai; Zhou, Ming; Hu, Huan; Liu, Hui; Cui, Jie; Li, Leliang; Yan, Dong; Cheng, Xiaoshu; Chen, Rong; Li, Ping

doi:10.1038/s41598-017-18086-3

Cited by 40 publications

(50 citation statements)

References 34 publications

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“…Thus, it is possible that adropin may promote arterial stiffness via NO-dependent signaling [53]. In line with this data, physical exercise upregulates circulating adropin in humans, which is accompanied by improved endothelial function [54]. Overall, these results suggest that low levels of adropin are associated with cardiovascular complication, such as endothelial dysfunction, cardiac syndrome X, or hypertension.…”

Section: Adropin In the Cardiovascular Systemsupporting

confidence: 69%

Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

et al. 2020

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Adropin is a unique hormone encoded by the energy homeostasis-associated (Enho) gene. Adropin is produced in the liver and brain, and also in peripheral tissues such as in the heart and gastrointestinal tract. Furthermore, adropin is present in the circulatory system. A decade after its discovery, there is evidence that adropin may contribute to body weight regulation, glucose and lipid homeostasis, and cardiovascular system functions. In this review, we summarize and discuss the physiological, metabolic, and pathophysiological factors regulating Enho as well as adropin. Furthermore, we review the literature addressing the role of adropin in adiposity and type 2 diabetes. Finally, we elaborate on the role of adropin in the context of the cardiovascular system, liver diseases, and cancer.

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Section: Adropin In the Cardiovascular Systemsupporting

confidence: 69%

Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

et al. 2020

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“…Zhang et al (50) found IR index is a negative independent risk factor of ADR levels in obese adolescents. Yosaee et al (51) reported that subjects with metabolic syndrome had significantly lower ADR levels and adropin/leptin ratio and ADR levels were correlated with metabolic syndrome and hence is a potentially protective agent against its development.…”

Section: Discussion:-mentioning

confidence: 99%

Serum Adropin and Adipose Fatty-Acid Binding Protein at 6th Week of Pregnancy Are Significant Predictors for Development of Insulin Resistance at the 24th Week.

Sharafeldeen¹

2018

IJAR

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“…Kumar et al suggested that adropin is an hepatokine that is decreased in diet-induced obese mice and showed that transgenic overexpression or systemic adropin treatment attenuated steatosis by suppressing the expression of Fas and the gene for Stearoyl-CoA desaturase-1 ( Scd1 ) ( 80 ). Aerobic training increased serum adropin levels in humans, and this was associated with reduced arterial stiffness ( 84 ) and improvements in endothelial function ( 85 ).…”

Section: Mechanisms By Which Exercise Improves Nafld; a Narrative Revmentioning

confidence: 99%

Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms

et al. 2018

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Exercise training ameliorates nonalcoholic fatty liver disease (NAFLD) as well as obesity and metabolic syndrome. Although it is difficult to eliminate the effects of body weight reduction and increased energy expenditure—some pleiotropic effects of exercise training—a number of studies involving either aerobic exercise training or resistance training programs showed ameliorations in NAFLD that are independent of the improvements in obesity and insulin resistance. In vivo studies have identified effects of exercise training on the liver, which may help to explain the “direct” or “independent” effect of exercise training on NAFLD. Exercise training increases peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) expression, improves mitochondrial function and leads to reduced hepatic steatosis, inflammation, fibrosis, and tumor genesis. Crosstalk between the liver and adipose tissue, skeletal muscle and the microbiome is also a possible mechanism for the effect of exercise training on NAFLD. Although numerous studies have reported benefits of exercise training on NAFLD, the optimal duration and intensity of exercise for the prevention or treatment of NAFLD have not been established. Maintaining adherence of patients with NAFLD to exercise training regimes is another issue to be resolved. The use of comprehensive analytical approaches to identify biomarkers such as hepatokines that specifically reflect the effect of exercise training on liver functions might help to monitor the effect of exercise on NAFLD, and thereby improve adherence of these patients to exercise training. Exercise training is a robust approach for alleviating the pathogenesis of NAFLD, although further clinical and experimental studies are required.

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Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss

Cited by 40 publications

References 34 publications

Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

Adropin as A Fat-Burning Hormone with Multiple Functions—Review of a Decade of Research

Serum Adropin and Adipose Fatty-Acid Binding Protein at 6th Week of Pregnancy Are Significant Predictors for Development of Insulin Resistance at the 24th Week.

Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms

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