Plasma adiponectin response to acute exercise in healthy subjects

Abstract

Adipose tissue secretes adiponectin, an adipocytokine that is involved in the regulation of insulin sensitivity. Following acute exercise, insulin sensitivity has been shown to increase. Increased adiponectin following exercise may be related to the change in insulin sensitivity. The purpose of the present study was to characterize the effect of a single cycle exercise session on adiponectin and to compare the exercise effects between healthy male and female subjects. Plasma concentrations of adiponectin, tissue necrosis factor-alpha (TNF-alpha), insulin, glucose, and leptin were assessed before and immediately after a 60-minute stationary cycle ergometry session at 65% of Vdot;O(2max). Male and female subjects were matched for cardiorespiratory fitness and body composition and dietary intake was controlled for the three days prior to the exercise trial. At rest, adiponectin concentration was not associated with percentage body fat, body mass index (BMI), fitness, or resting plasma variables ( P>0.05). Following exercise, neither male nor female subjects exhibited changes in adiponectin or leptin concentrations ( P>0.05). TNF-alpha exhibited a time main effect increase with exercise ( P<0.05), but there were no gender differences. These results suggest that plasma adiponectin concentrations do not change with exercise in healthy male or female subjects. Results are given as mean (SE).

The effects of acute exercise on serum adiponectin and resistin levels and their relation to insulin sensitivity in overweight males

“…Kriketos et al (2004) reported a significant increase in adiponectin levels in obese sedentary males following a short-term exercise training program (approximately 1 week). On the contrary, Ferguson et al (2004) reported no effect of a submaximal aerobic exercise bout on adiponectin concentration in young healthy normal weight individuals. Similarly, Kraemer et al (2003) indicated that there was no significant increase in adiponectin levels in young healthy males following a heavy continuous or intermittent running exercise.…”

“…Research on the effects of acute exercise on adiponectin levels has produced conflicting results. There are studies which have reported no effect of acute exercise on adiponectin levels in healthy, normal weight individuals (Ferguson et al 2004;Kraemer et al 2003;Punyadeera et al 2005). On the other hand, Jurimae et al (2005) reported a significant decrease immediately following exercise and significant increase 30 min post-exercise in healthy normal weight individuals, whereas Kriketos et al (2004) reported that very short exercise training (approximately 1 week) resulted in increased levels of adiponectin and insulin sensitivity in obese individuals without a concomitant body weight loss.…”

Relationships of physical activity with metabolic syndrome features and low-grade inflammation in adolescents

“…It has been suggested, among other possibilities, that physical activity could target some of the cytokines expressed by adipose tissue, such as adiponectin, leptin or soluble TNF-α receptor 1 (sTNF-α R1), that are suspected to modulate insulin sensitivity and inflammatory processes [2,10]. In adults, the relationship of physical activity with the adipokines, which has been studied mainly after an acute exercise bout, remains unclear [11][12][13][14]. In youths, only the relationships with leptin have been examined.…”

Factors determining the risk of the metabolic syndrome: is there a central role for adiponectin?

“…56 Regardless of the type of physical activity, adiponectin levels did not change up to 48 h post a single submaximal cycling exercise session. 57,58 A 24-week endurance training program too had limited effect. 59 However, adiponectin resistance did improve following a 4-month resistance and endurance exercise program, independent of the change in body composition.…”